Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 6x3t
Q-score: 0.642
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ Pubmed: 32879488 DOI: doi:10.1038/s41586-020-2654-5 ]
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2,6-bis(1-methylethyl)phenol (178 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and propofol (Complex from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 6x3x
Q-score: 0.554
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ Pubmed: 32879488 DOI: doi:10.1038/s41586-020-2654-5 ]
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and diazepam (Complex)
- 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (284 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 6x40
Q-score: 0.549
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ Pubmed: 32879488 DOI: doi:10.1038/s41586-020-2654-5 ]
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and picrotoxin (Complex from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3h)-dione (292 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)