Cryo-EM structure of IRL1620-bound ETBR-Gi complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8hbd
Q-score: 0.412
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ DOI: doi:10.1038/s41467-023-36998-9 Pubmed: 36882417 ]
- Irl1620-bound etbr-gi complex (Complex from Homo sapiens)
- Endothelin receptor type b,endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Irl1620 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of endothelin1-bound ETAR-Gq complex
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8hcq
Q-score: 0.394
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ DOI: doi:10.1038/s41467-023-36998-9 Pubmed: 36882417 ]
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Endothelin-1 receptor,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (69 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
Cryo-EM structure of Endothelin1-bound ETBR-Gq complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hcx
Q-score: 0.346
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ DOI: doi:10.1038/s41467-023-36998-9 Pubmed: 36882417 ]
- Endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
S protein of SARS-CoV-2 in complex with 2G1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7x08
Q-score: 0.458
Ma H, Guo Y, Tang H, Tseng CK, Wang L, Zong H, Wang Z, He Y, Chang Y, Wang S, Huang H, Ke Y, Yuan Y, Wu M, Zhang Y, Drelich A, Kempaiah KR, Peng BH, Wang A, Yang K, Yin H, Liu J, Yue Y, Xu W, Zhu S, Ji T, Zhang X, Wang Z, Li G, Liu G, Song J, Mu L, Xiang Z, Song Z, Chen H, Bian Y, Zhang B, Chen H, Zhang J, Liao Y, Zhang L, Yang L, Chen Y, Gilly J, Xiao X, Han L, Jiang H, Xie Y, Zhou Q, Zhu J
Cell Discov (2022) 8 pp. 16-16 [ DOI: doi:10.1038/s41421-022-00381-7 Pubmed: 35169121 ]
- S protein of sars-cov-2 in complex with 2g1 (Complex)
- Light chain of 2g1 (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of 2g1 (49 kDa, Protein from Homo sapiens)
- 2g1 (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Linoleic acid (280 Da, Ligand)
- S protein of sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus)
Structure of the human GluN1-GluN2A NMDA receptor in complex with S-ketamine, glycine and glutamate
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7eu7
Q-score: 0.446
Zhang Y, Ye F, Zhang T, Lv S, Zhou L, Du D, Lin H, Guo F, Luo C, Zhu S
Nature (2021) 596 pp. 301-305 [ DOI: doi:10.1038/s41586-021-03769-9 Pubmed: 34321660 ]
- Human glun1 (Complex from Homo sapiens)
- Human glun2 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2~{s})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (237 Da, Ligand)
- Structure of the human glun1/glun2a nmda receptor in complex with s-ketamine, glycine and glutamate, at ph 8.0 (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
Structure of the human GluN1-GluN2B NMDA receptor in complex with S-ketamine,glycine and glutamate
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 7eu8
Q-score: 0.29
Zhang Y, Ye F, Zhang T, Lv S, Zhou L, Du D, Lin H, Guo F, Luo C, Zhu S
Nature (2021) 596 pp. 301-305 [ DOI: doi:10.1038/s41586-021-03769-9 Pubmed: 34321660 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2~{s})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (237 Da, Ligand)
- Tetrameric complex of glun1 and glun2b subunits (383 MDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2b (96 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6ira
Q-score: 0.227
Zhang JB, Chang S, Xu P, Miao M, Wu H, Zhang Y, Zhang T, Wang H, Zhang J, Xie C, Song N, Luo C, Zhang X, Zhu S
Cell Rep (2018) 25 pp. 3582-3590.e4 [ DOI: doi:10.1016/j.celrep.2018.11.071 Pubmed: 30590034 ]
- Human glun1/glun2a nmda receptors in the glutamate/glycine-bound state at ph 7.8 (380 kDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
Resolution: 5.1 Å
EM Method: Single-particle
Fitted PDBs: 6irf
Q-score: 0.158
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 6irg
Q-score: 0.147
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 6irh
Q-score: 0.171