Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 9e6k
Q-score: 0.473
Saha N, Lee SG, Brockmann EC, de la Cruz MJ, Goldgur Y, Mendoza RP, Stanchina E, Love TM, Marvald J, Xu Y, Xu K, Himanen JP, Lamminmaki U, Veach D, Nikolov DB
Biomed Pharmacother (2024) 180 pp. 117605-117605 [ Pubmed: 39461016 DOI: doi:10.1016/j.biopha.2024.117605 ]
- Disintegrin and metalloproteinase domain-containing protein 17 (12 kDa, Protein from Homo sapiens)
- Complex of adam17 disintegrin-cysteine rich domain (Complex from Homo sapiens)
- Heavy chain of monoclonal antibody c12 (23 kDa, Protein from Homo sapiens)
- Light chain monoclonal antibody c12 (23 kDa, Protein from Homo sapiens)
Androgen receptor bound to DNA - Entrenched state
Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W, Watson PA, Zinder JC, Karthaus WR, de la Cruz MJ, Hite RK, Manova-Todorova K, Yu Z, Weintraub ST, Klinge S, Sawyers CL
Mol Cell (2022) 82 pp. 2021-2031.e5 [ DOI: doi:10.1016/j.molcel.2022.03.035 Pubmed: 35447082 ]
Androgen receptor bound to DNA - Splayed state
Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W, Watson PA, Zinder JC, Karthaus WR, de la Cruz MJ, Hite RK, Manova-Todorova K, Yu Z, Weintraub ST, Klinge S, Sawyers CL
Mol Cell (2022) 82 pp. 2021-2031.e5 [ DOI: doi:10.1016/j.molcel.2022.03.035 Pubmed: 35447082 ]
Androgen receptor bound to DNA - Divorced state
Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W, Watson PA, Zinder JC, Karthaus WR, de la Cruz MJ, Hite RK, Manova-Todorova K, Yu Z, Weintraub ST, Klinge S, Sawyers CL
Mol Cell (2022) 82 pp. 2021-2031.e5 [ DOI: doi:10.1016/j.molcel.2022.03.035 Pubmed: 35447082 ]
- Ar (Protein from Mus musculus)
- Androgen receptor bound to dna - divorced state (Complex from Mus musculus)
- Are-35 (DNA from Homo sapiens)
Cryo-EM structure of DNMT5 in apo state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7r76
Q-score: 0.479
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ DOI: doi:10.1016/j.molcel.2022.01.028 Pubmed: 35202575 ]
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487))
- Zinc ion (65 Da, Ligand)
- Dnmt5 (260 kDa, Complex from Cryptococcus neoformans)
Cryo-EM structure of DNMT5 binary complex with hemimethylated DNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7r77
Q-score: 0.548
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ DOI: doi:10.1016/j.molcel.2022.01.028 Pubmed: 35202575 ]
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487))
- Dnmt5 (260 kDa, Complex from Cryptococcus neoformans)
- Dna (5'-d(p*gp*tp*cp*ap*gp*(5cm)p*gp*cp*ap*tp*gp*g)-3') (11 kDa, DNA from Cryptococcus neoformans)
- Dna (5'-d(p*gp*tp*cp*ap*gp*(5cm)p*gp*cp*ap*tp*gp*g)-3') (10 kDa, DNA from Cryptococcus neoformans)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of DNMT5 quaternary complex with hemimethylated DNA, AMP-PNP and SAH
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7r78
Q-score: 0.498
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ DOI: doi:10.1016/j.molcel.2022.01.028 Pubmed: 35202575 ]
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487))
- Dna (5'-d(*tp*gp*cp*gp*cp*tp*gp*ap*cp*a)-3') (10 kDa, DNA from Cryptococcus neoformans)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dnmt5 in complex with hemimethylated dna, amp-pnp and sah (260 kDa, Complex from Cryptococcus neoformans)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Dna (5'-d(p*cp*ap*gp*(5cm)p*gp*cp*ap*t)-3') (11 kDa, DNA from Cryptococcus neoformans)
- Zinc ion (65 Da, Ligand)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7t02
Q-score: 0.477
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ DOI: doi:10.1016/j.molcel.2022.01.028 Pubmed: 35202575 ]
- Dnmt5 (260 kDa, Complex from Cryptococcus neoformans)
- Dna (5'-d(p*gp*tp*cp*ap*gp*(5cm)p*gp*cp*ap*tp*gp*g)-3') (11 kDa, DNA from Cryptococcus neoformans)
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii H99)
- Dna (5'-d(*cp*cp*ap*tp*gp*cp*gp*cp*tp*gp*ap*cp*a)-3') (10 kDa, DNA from Cryptococcus neoformans)
- Zinc ion (65 Da, Ligand)
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 7ld5
Q-score: 0.541
Unciuleac MC, Ghosh S, de la Cruz MJ, Goldgur Y, Shuman S
RNA (2021) 27 pp. 959-969 [ DOI: doi:10.1261/rna.078822.121 Pubmed: 34088850 ]
- Poly-a rna fragment (2 kDa, RNA from synthetic construct)
- Polyribonucleotide nucleotidyltransferase (83 kDa, Protein from Mycolicibacterium smegmatis)
- Polynucleotide phosphorylase complex in poly(a) synthesis (Complex from Mycolicibacterium smegmatis)
- Magnesium ion (24 Da, Ligand)
Structure of human SHLD2-SHLD3-REV7-TRIP13(E253Q) complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7l9p
Q-score: 0.397
Xie W, Wang S, Wang J, de la Cruz MJ, Xu G, Scaltriti M, Patel DJ
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2024512118 Pubmed: 33597306 ]
- Pachytene checkpoint protein 2 homolog (48 kDa, Protein from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Mitotic spindle assembly checkpoint protein mad2b (24 kDa, Protein from Homo sapiens)
- Shld2.3-rev7(4)-trip13(e253q) complex with atp-gamma-s (Complex from Homo sapiens)
- Shieldin complex subunit 2, shieldin complex subunit 3 chimera (10 kDa, Protein from Homo sapiens)