Human liver phosphofructokinase-1 filament in the R-state conformation
Lynch EM, Hansen H, Salay L, Cooper M, Timr S, Kollman JM, Webb BA
Nat Commun (2024) 15 pp. 7323-7323 [ DOI: doi:10.1038/s41467-024-51808-6 Pubmed: 39183237 ]
- 1,6-di-o-phosphono-beta-d-fructofuranose (340 Da, Ligand)
- Atp-dependent 6-phosphofructokinase, liver type (85 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 6-o-phosphono-beta-d-fructofuranose (260 Da, Ligand)
- Pfkl filament (Complex from Homo sapiens)
Human liver phosphofructokinase-1 in the R-state conformation
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w2g
Q-score: 0.545
Lynch EM, Hansen H, Salay L, Cooper M, Timr S, Kollman JM, Webb BA
Nat Commun (2024) 15 pp. 7323-7323 [ DOI: doi:10.1038/s41467-024-51808-6 Pubmed: 39183237 ]
- 1,6-di-o-phosphono-beta-d-fructofuranose (340 Da, Ligand)
- Pfkl tetramer (Complex from Homo sapiens)
- Atp-dependent 6-phosphofructokinase, liver type (85 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 6-o-phosphono-beta-d-fructofuranose (260 Da, Ligand)
Human liver phosphofructokinase-1 in the T-state conformation
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8w2h
Q-score: 0.596
Lynch EM, Hansen H, Salay L, Cooper M, Timr S, Kollman JM, Webb BA
Nat Commun (2024) 15 pp. 7323-7323 [ DOI: doi:10.1038/s41467-024-51808-6 Pubmed: 39183237 ]
- 1,6-di-o-phosphono-beta-d-fructofuranose (340 Da, Ligand)
- Pfkl tetramer (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Atp-dependent 6-phosphofructokinase, liver type (85 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Human liver phosphofructokinase-1 filament in the T-state conformation
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w2j
Q-score: 0.448
Lynch EM, Hansen H, Salay L, Cooper M, Timr S, Kollman JM, Webb BA
Nat Commun (2024) 15 pp. 7323-7323 [ DOI: doi:10.1038/s41467-024-51808-6 Pubmed: 39183237 ]
- 1,6-di-o-phosphono-beta-d-fructofuranose (340 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Atp-dependent 6-phosphofructokinase, liver type (85 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Pfkl filament (Complex from Homo sapiens)
Human phosphofructokinase-1 liver type bound to activator NA-11
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7lw1
Q-score: 0.543
Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, Kollman JM, Ma T, Yu K, Lai Z, Sangaraju D, Kayagaki N, Newton K, Bogyo M, Staben ST, Dixit VM
Cell (2021) 184 pp. 4480-4494.e15 [ Pubmed: 34320407 DOI: doi:10.1016/j.cell.2021.07.004 ]
- 1,6-di-o-phosphono-beta-d-fructofuranose (340 Da, Ligand)
- N-{(11s)-2-[2-(5-hydroxypent-1-yn-1-yl)phenyl]-4h,10h-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl}acetamide (401 Da, Ligand)
- Atp-dependent 6-phosphofructokinase, liver type (85 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Human phosphofructokinase-1 liver type bound to activator na-11 (Complex from Homo sapiens)
- 6-o-phosphono-beta-d-fructofuranose (260 Da, Ligand)
Escherichia coli AGPase in complex with FBP.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6r8b
Q-score: 0.536
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
bioRxiv (2020) [ DOI: doi:10.1101/2020.01.24.916759 ]
Escherichia coli AGPase in complex with FBP. Symmetry applied C2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6shj
Q-score: 0.521
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
Curr Res Struct Biol (2020) 2 pp. 89-103 [ Pubmed: 34235472 DOI: doi:10.1016/j.crstbi.2020.04.005 ]
Escherichia coli AGPase in complex with FBP. Symmetry C1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6shn
Q-score: 0.492
Cifuente JO, Comino N, D'Angelo C, Marina A, Gil-Carton D, Albesa-Jove D, Guerin ME
Curr Res Struct Biol (2020) 2 pp. 89-103 [ Pubmed: 34235472 DOI: doi:10.1016/j.crstbi.2020.04.005 ]
PKM2 in complex with Compound 5
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6ttf
Q-score: 0.548
Saur M, Hartshorn MJ, Dong J, Reeks J, Bunkoczi G, Jhoti H, Williams PA
Drug Discov Today (2020) 25 pp. 485-490 [ Pubmed: 31877353 DOI: doi:10.1016/j.drudis.2019.12.006 ]
- 1,6-di-o-phosphono-beta-d-fructofuranose (340 Da, Ligand)
- Water (18 Da, Ligand)
- Pyruvate kinase m2 (240 kDa, Complex from Homo sapiens)
- Pyruvate kinase pkm (59 kDa, Protein from Homo sapiens)
- 5-hydroxynaphthalene-1-sulfonamide (223 Da, Ligand)
PKM2 in complex with L-threonine
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6tth
Q-score: 0.652
Saur M, Hartshorn MJ, Dong J, Reeks J, Bunkoczi G, Jhoti H, Williams PA
Drug Discov Today (2020) 25 pp. 485-490 [ Pubmed: 31877353 DOI: doi:10.1016/j.drudis.2019.12.006 ]
- 1,6-di-o-phosphono-beta-d-fructofuranose (340 Da, Ligand)
- Water (18 Da, Ligand)
- Pyruvate kinase m2 (240 kDa, Complex from Homo sapiens)
- Pyruvate kinase pkm (59 kDa, Protein from Homo sapiens)
- Threonine (119 Da, Ligand)