Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ Pubmed: 36253376 DOI: doi:10.1038/s41467-022-33860-2 ]
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ Pubmed: 36253376 DOI: doi:10.1038/s41467-022-33860-2 ]
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ Pubmed: 36253376 DOI: doi:10.1038/s41467-022-33860-2 ]
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ Pubmed: 36253376 DOI: doi:10.1038/s41467-022-33860-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg24 mature fab heavy chain (13 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 mature fab light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24 fabs with an inferred germline light chain and 10-1074 fabs in complex with hiv-1 env immunogen bg505-sosipv4.1-gt1 containing the n276 gp120 glycan- class 1 (Complex from Human immunodeficiency virus 1)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (49 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ugq
Q-score: 0.47
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ Pubmed: 36253376 DOI: doi:10.1038/s41467-022-33860-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg24 with an inferred germline cdrl1 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Bg24 with an inferred germline cdrl1 fab light chain (11 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24 fabs with an inferred germline cdrl1 and 10-1074 fabs in complex with hiv-1 env 6405-sosip.664 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (50 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ugn
Q-score: 0.477
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ Pubmed: 36253376 DOI: doi:10.1038/s41467-022-33860-2 ]
- Bg24 inferred germline fab with germline cdr3s heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (50 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Bg24 inferred germline fab with germline cdr3s light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24-igl cdr3igl and 10-1074 fabs in complex with bg505 sosip.664v4.1-gt1 env trimer immunogen (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- Alpha-d-mannopyranose (180 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7ugo
Q-score: 0.425
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ Pubmed: 36253376 DOI: doi:10.1038/s41467-022-33860-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em map of bg24-igl cdr3mat and 10-1074 fabs in complex with bg505 sosip.664v4.1-gt1 env trimer immunogen (Complex from Human immunodeficiency virus 1)
- Alpha-d-mannopyranose (180 Da, Ligand)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 inferred germline fab with mature cdr3s light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 inferred germline fab with mature cdr3s heavy chain (13 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ucg
Q-score: 0.411
Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West Jr AP, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ
Sci Adv (2022) 8 pp. eabp8155-eabp8155 [ DOI: doi:10.1126/sciadv.abp8155 Pubmed: 35960796 ]
- Bg24 light chain (21 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 10-1074 fab heavy chain (26 kDa, Protein from Homo sapiens)
- Bg24 cdrh2-v2 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Complex of du422 sosip trimer bound to 10-1074 and bg24 fab fragments (650 kDa, Complex from Homo sapiens)
- Envelope glycoprotein gp160 (56 kDa, Protein from Human immunodeficiency virus 1)