Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 8g6u
Q-score: 0.433
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Light chain of 10-1074 (23 kDa, Protein from Homo sapiens)
- Crf01_ae t/f100 hiv-1 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer with lmhs mutations in complex with 8anc195 and 10-1074 (6 MDa, Complex from Human immunodeficiency virus 1)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 10-1074 (25 kDa, Protein from Homo sapiens)
- Heavy chain of 8anc195 (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 8anc195 (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8ttw
Q-score: 0.507
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Antibody 8anc195 heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (54 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.664 transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione (473 Da, Ligand)
- Antibody 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Complex of bg505 sosip.664 with temsavir and the antibody fabs of 8anc195 and 10-1074 (Complex from Homo sapiens)
- Antibody 10-1074 heavy chain (25 kDa, Protein from Homo sapiens)
- Antibody 8anc195 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8dok
Q-score: 0.484
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer in complex with 8anc195 and 10-1074 (6 MDa, Complex from Homo sapiens)
- Light chain of 10-1074 (23 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 10-1074 (25 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 env gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 8anc195 (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 8anc195 (23 kDa, Protein from Homo sapiens)
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 mature fab heavy chain (13 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24 fabs with an inferred germline light chain and 10-1074 fabs in complex with hiv-1 env immunogen bg505-sosipv4.1-gt1 containing the n276 gp120 glycan- class 1 (Complex from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (49 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 mature fab light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ugq
Q-score: 0.47
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Bg24 with an inferred germline cdrl1 fab light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24 fabs with an inferred germline cdrl1 and 10-1074 fabs in complex with hiv-1 env 6405-sosip.664 (Complex from Human immunodeficiency virus 1)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (50 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 with an inferred germline cdrl1 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ugn
Q-score: 0.477
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Envelope glycoprotein gp120 (50 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 inferred germline fab with germline cdr3s light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24-igl cdr3igl and 10-1074 fabs in complex with bg505 sosip.664v4.1-gt1 env trimer immunogen (Complex from Human immunodeficiency virus 1)
- Alpha-d-mannopyranose (180 Da, Ligand)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Bg24 inferred germline fab with germline cdr3s heavy chain (13 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7ugo
Q-score: 0.425
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Bg24 inferred germline fab with mature cdr3s heavy chain (13 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 inferred germline fab with mature cdr3s light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em map of bg24-igl cdr3mat and 10-1074 fabs in complex with bg505 sosip.664v4.1-gt1 env trimer immunogen (Complex from Human immunodeficiency virus 1)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ucg
Q-score: 0.411
Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West Jr AP, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ
Sci Adv (2022) 8 pp. eabp8155-eabp8155 [ Pubmed: 35960796 DOI: doi:10.1126/sciadv.abp8155 ]
- 10-1074 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of du422 sosip trimer bound to 10-1074 and bg24 fab fragments (650 kDa, Complex from Homo sapiens)
- 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Bg24 light chain (21 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 cdrh2-v2 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (56 kDa, Protein from Human immunodeficiency virus 1)
VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6v8z
Q-score: 0.358
Henderson R, Lu M, Zhou Y, Mu Z, Parks R, Han Q, Hsu AL, Carter E, Blanchard SC, Edwards RJ, Wiehe K, Saunders KO, Borgnia MJ, Bartesaghi A, Mothes W, Haynes BF, Acharya P, Munir Alam S
Nat Commun (2020) 11 pp. 520-520 [ Pubmed: 31980614 DOI: doi:10.1038/s41467-019-14196-w ]
- Envelope glycoprotein gp41 (16 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 f14/vt8 hiv-1 sosip env trimer (Complex from Human immunodeficiency virus 1)
- 10-1074 (Complex from Homo sapiens)
- 10-1074 fab light chain (22 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Complex between vrc03, 10-1074, and bg505 f14 hiv-1 sosip env trimer (Complex)
- Vrc03 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10-1074 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Vrc03 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc03 (Complex from Homo sapiens)
HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6udj
Q-score: 0.632
Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fatkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F
Cell (2020) 180 pp. 471- [ DOI: doi:10.1016/j.cell.2020.01.010 Pubmed: 32004464 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Water (18 Da, Ligand)
- Complex of bnabs 1-18 and 10-1074 in complex with bg505 sosip.664 trimer (300 kDa, Complex)
- 1-18 fab heavy chain (53 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-18 fab (Complex from Homo sapiens)
- 1-18 fab light chain (25 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- 10-1074 fab (Complex from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)