Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 8g6u
Q-score: 0.433
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Light chain of 10-1074 (23 kDa, Protein from Homo sapiens)
- Crf01_ae t/f100 hiv-1 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer with lmhs mutations in complex with 8anc195 and 10-1074 (6 MDa, Complex from Human immunodeficiency virus 1)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 10-1074 (25 kDa, Protein from Homo sapiens)
- Heavy chain of 8anc195 (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 8anc195 (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8dok
Q-score: 0.484
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer in complex with 8anc195 and 10-1074 (6 MDa, Complex from Homo sapiens)
- Light chain of 10-1074 (23 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 10-1074 (25 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 env gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 8anc195 (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 8anc195 (23 kDa, Protein from Homo sapiens)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8czz
Q-score: 0.428
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione (473 Da, Ligand)
- Light chain of 8anc195 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of 10-1074 fab (25 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer with lmhs mutations in complex with temsavir, 8anc195, and 10-1074 (6 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Crf01_ae t/f100 hiv-1 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 8anc195 fab (25 kDa, Protein from Homo sapiens)
- Light chain of 10-1074 fab (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)