Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 8g6u
Q-score: 0.433
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Light chain of 10-1074 (23 kDa, Protein from Homo sapiens)
- Crf01_ae t/f100 hiv-1 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer with lmhs mutations in complex with 8anc195 and 10-1074 (6 MDa, Complex from Human immunodeficiency virus 1)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 10-1074 (25 kDa, Protein from Homo sapiens)
- Heavy chain of 8anc195 (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 8anc195 (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8ttw
Q-score: 0.507
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Antibody 8anc195 heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (54 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.664 transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione (473 Da, Ligand)
- Antibody 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Complex of bg505 sosip.664 with temsavir and the antibody fabs of 8anc195 and 10-1074 (Complex from Homo sapiens)
- Antibody 10-1074 heavy chain (25 kDa, Protein from Homo sapiens)
- Antibody 8anc195 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8dok
Q-score: 0.484
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer in complex with 8anc195 and 10-1074 (6 MDa, Complex from Homo sapiens)
- Light chain of 10-1074 (23 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 10-1074 (25 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 env gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 8anc195 (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 8anc195 (23 kDa, Protein from Homo sapiens)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8czz
Q-score: 0.428
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ DOI: doi:10.1038/s41467-023-42500-2 Pubmed: 37872202 ]
- 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione (473 Da, Ligand)
- Light chain of 8anc195 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of 10-1074 fab (25 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer with lmhs mutations in complex with temsavir, 8anc195, and 10-1074 (6 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Crf01_ae t/f100 hiv-1 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of 8anc195 fab (25 kDa, Protein from Homo sapiens)
- Light chain of 10-1074 fab (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ucg
Q-score: 0.411
Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West Jr AP, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ
Sci Adv (2022) 8 pp. eabp8155-eabp8155 [ Pubmed: 35960796 DOI: doi:10.1126/sciadv.abp8155 ]
- 10-1074 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of du422 sosip trimer bound to 10-1074 and bg24 fab fragments (650 kDa, Complex from Homo sapiens)
- 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Bg24 light chain (21 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 cdrh2-v2 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (56 kDa, Protein from Human immunodeficiency virus 1)
HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6udj
Q-score: 0.632
Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fatkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F
Cell (2020) 180 pp. 471- [ DOI: doi:10.1016/j.cell.2020.01.010 Pubmed: 32004464 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Water (18 Da, Ligand)
- Complex of bnabs 1-18 and 10-1074 in complex with bg505 sosip.664 trimer (300 kDa, Complex)
- 1-18 fab heavy chain (53 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-18 fab (Complex from Homo sapiens)
- 1-18 fab light chain (25 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- 10-1074 fab (Complex from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6udk
Q-score: 0.442
Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fatkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F
Cell (2020) 180 pp. 471- [ DOI: doi:10.1016/j.cell.2020.01.010 Pubmed: 32004464 ]
- Rc1 variant of hiv-1 bg505 sosip.664 (Complex from Human immunodeficiency virus 1)
- Complex of three bnab 1-55 fabs and three 10-1074 fabs bound to rc1 variant of bg505 sosip.664 trimer (300 kDa, Complex)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-55 fab light chain (25 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (23 kDa, Protein from Homo sapiens)
- 1-55 fab (Complex from Homo sapiens)
- 10-1074 fab (Complex from Homo sapiens)
- 10-1074 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 1-55 fab heavy chain (28 kDa, Protein from Homo sapiens)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 6okp
Q-score: 0.468
Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West Jr AP, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ
Immunity (2019) 50 pp. 1513- [ Pubmed: 31126879 DOI: doi:10.1016/j.immuni.2019.04.014 ]
- Sf12 heavy chain,sf12 heavy chain (26 kDa, Protein from Homo sapiens)
- B41 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Sf12 light chain,sf12 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Sf12 fab (Complex from Homo sapiens)
- 10-1074 fab (Complex from Homo sapiens)
- 10-1074 heavy chain,10-1074 heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Complex of b41 sosip.664 trimer with three sf12 fabs and one 10-1074 fab (540 kDa, Complex)
- 10-1074 light chain,10-1074 light chain (23 kDa, Protein from Homo sapiens)
Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West Jr AP, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ
Immunity (2019) 50 pp. 1513-1529.e9 [ Pubmed: 31126879 DOI: doi:10.1016/j.immuni.2019.04.014 ]