Structure of mitochondrial complex I from Drosophila melanogaster, Flexible-class 1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8esw
Q-score: 0.504
Padavannil A, Murari A, Rhooms SK, Owusu-Ansah E, Letts JA
eLife (2023) 12 [ DOI: doi:10.7554/eLife.84415 Pubmed: 36952377 ]
- Nadh dehydrogenase (ubiquinone) 13 kda b subunit (13 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (20 kDa, Protein from Drosophila melanogaster)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (17 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (14 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (12 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (12 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3 (2 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (11 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (46 kDa, Protein from Drosophila melanogaster)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (16 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (13 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 5 (65 kDa, Protein from Drosophila melanogaster)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase (ubiquinone) 24 kda subunit, isoform a (26 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 6 (20 kDa, Protein from Drosophila melanogaster)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (22 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (18 kDa, Protein from Drosophila melanogaster)
- Mitochondrial complex i from the thoracic muscles of d. melanogaster (Complex from Drosophila melanogaster)
- Complex i-49kd (52 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 4l (11 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (14 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase (ubiquinone) 39 kda subunit, isoform a (46 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 1 (36 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (78 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Drosophila melanogaster)
- Zinc ion (65 Da, Ligand)
- Rh45008p (8 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase (ubiquinone) 23 kda subunit (24 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (18 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (51 kDa, Protein from Drosophila melanogaster)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Ld31474p (24 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (16 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (19 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (17 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (20 kDa, Protein from Drosophila melanogaster)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Drosophila melanogaster)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Drosophila melanogaster)
- Iron/sulfur cluster (351 Da, Ligand)
- Geo11417p1 (10 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (14 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (13 kDa, Protein from Drosophila melanogaster)
- S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Structure of mitochondrial complex I from Drosophila melanogaster, Helix-locked state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8esz
Q-score: 0.498
Padavannil A, Murari A, Rhooms SK, Owusu-Ansah E, Letts JA
eLife (2023) 12 [ DOI: doi:10.7554/eLife.84415 Pubmed: 36952377 ]
- Nadh dehydrogenase (ubiquinone) 13 kda b subunit (13 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (20 kDa, Protein from Drosophila melanogaster)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (17 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (14 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (12 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3 (3 kDa, Protein from Drosophila melanogaster)
- (2r)-3-{[(s)-hydroxy(3-methylbutoxy)phosphoryl]oxy}-2-(octanoyloxy)propyl decanoate (522 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (12 kDa, Protein from Drosophila melanogaster)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (11 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (46 kDa, Protein from Drosophila melanogaster)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (16 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (13 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 5 (65 kDa, Protein from Drosophila melanogaster)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase (ubiquinone) 24 kda subunit, isoform a (26 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 6 (20 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Drosophila melanogaster)
- Dodecane (170 Da, Ligand)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (22 kDa, Protein from Drosophila melanogaster)
- Mitochondrial complex i from the thoracic muscle of drosophila melanogaster (Complex from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (18 kDa, Protein from Drosophila melanogaster)
- Complex i-49kd (52 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 4l (11 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (14 kDa, Protein from Drosophila melanogaster)
- Ubiquinone-10 (863 Da, Ligand)
- Nadh dehydrogenase (ubiquinone) 39 kda subunit, isoform a (46 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 1 (36 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (78 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Drosophila melanogaster)
- N-octane (114 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Rh45008p (8 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase (ubiquinone) 23 kda subunit (24 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (18 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (51 kDa, Protein from Drosophila melanogaster)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Ld31474p (24 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (16 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (19 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (17 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (20 kDa, Protein from Drosophila melanogaster)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Drosophila melanogaster)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Drosophila melanogaster)
- Iron/sulfur cluster (351 Da, Ligand)
- Geo11417p1 (10 kDa, Protein from Drosophila melanogaster)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (14 kDa, Protein from Drosophila melanogaster)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (13 kDa, Protein from Drosophila melanogaster)
- S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Entire ovine respiratory complex I, Combined Map
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 5lnk
Q-score: 0.408
Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA
Nature (2016) 538 pp. 406-410 [ Pubmed: 27595392 DOI: doi:10.1038/nature19794 ]
- Mitochondrial complex i, 49 kda subunit (47 kDa, Protein from Sheep)
- Cardiolipin (1 kDa, Ligand)
- Mitochondrial complex i, b15 subunit (14 kDa, Protein from Sheep)
- Mitochondrial complex i, 24 kda subunit (23 kDa, Protein from Sheep)
- Mitochondrial complex i, b22 subunit (21 kDa, Protein from Sheep)
- Mitochondrial complex i, kfyi subunit (5 kDa, Protein from Sheep)
- Mitochondrial complex i (970 kDa, Complex from Ovis aries)
- Mitochondrial complex i, nd1 subunit (35 kDa, Protein from Sheep)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
- 4'-phosphopantetheine (358 Da, Ligand)
- Mitochondrial complex i, b14.7 subunit (10 kDa, Protein from Sheep)
- Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
- Mitochondrial complex i, aggg subunit (8 kDa, Protein from Sheep)
- Mitochondrial complex i, nd4 subunit (52 kDa, Protein from Sheep)
- Mitochondrial complex i, 39 kda subunit (38 kDa, Protein from Sheep)
- Mitochondrial complex i, nd2 subunit (39 kDa, Protein from Sheep)
- Mitochondrial complex i, nd4l subunit (10 kDa, Protein from Sheep)
- Mitochondrial complex i, 18 kda subunit (15 kDa, Protein from Sheep)
- Acyl carrier protein (10 kDa, Protein from Sheep)
- Mitochondrial complex i, 15 kda subunit (12 kDa, Protein from Sheep)
- Mitochondrial complex i, b14.5b subunit (14 kDa, Protein from Sheep)
- Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
- Mitochondrial complex i, 30 kda subunit (26 kDa, Protein from Sheep)
- Mitochondrial complex i, nd3 subunit (13 kDa, Protein from Sheep)
- Mitochondrial complex i, nd6 subunit (19 kDa, Protein from Sheep)
- Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
- Mitochondrial complex i, sgdh subunit (16 kDa, Protein from Sheep)
- Mitochondrial complex i, mnll subunit (6 kDa, Protein from Sheep)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from Sheep)
- Mitochondrial complex i, esss subunit (14 kDa, Protein from Sheep)
- Mitochondrial complex i, b17.2 subunit (17 kDa, Protein from Sheep)
- Mitochondrial complex i, b8 subunit (10 kDa, Protein from Sheep)
- Mitochondrial complex i, b14 subunit (14 kDa, Protein from Sheep)
- Mitochondrial complex i, 51 kda subunit (48 kDa, Protein from Sheep)
- Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
- Mitochondrial complex i, 10 kda subunit (8 kDa, Protein from Sheep)
- Mitochondrial complex i, b9 subunit (9 kDa, Protein from Sheep)
- Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
- Zinc ion (65 Da, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
- Mitochondrial complex i, 13 kda subunit (10 kDa, Protein from Sheep)
- Mitochondrial complex i, 42 kda subunit (36 kDa, Protein from Sheep)
- Mitochondrial complex i, b18 subunit (16 kDa, Protein from Sheep)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Mitochondrial complex i, 75 kda subunit (77 kDa, Protein from Sheep)
- Mitochondrial complex i, psst subunit (20 kDa, Protein from Sheep)
- Iron/sulfur cluster (351 Da, Ligand)
- Mitochondrial complex i, pgiv subunit (20 kDa, Protein from Sheep)
- Mitochondrial complex i, tyky subunit (20 kDa, Protein from Sheep)
- Mitochondrial complex i, nd5 subunit (67 kDa, Protein from Sheep)
- Mitochondrial complex i, b12 subunit (11 kDa, Protein from Sheep)
- S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Architecture of ovine respiratory supercomplex (I-III2-IV) conformation loose
Resolution: 6.7 Å
EM Method: Single-particle
Fitted PDBs: 5j7y
Q-score: 0.265
Letts JA, Fiedorczuk K, Sazanov LA
Nature (2016) 537 pp. 644-648 [ DOI: doi:10.1038/nature19774 Pubmed: 27654913 ]
- Respiratory complex iii (Complex from Ovis aries)
- Cox5b (Protein from Sheep)
- Cox3 (Protein from Sheep)
- Kfyi (Protein from Sheep)
- Cox7a (Protein from Sheep)
- Cox8b (Protein from Sheep)
- B15 (Protein from Sheep)
- 24 kda (Protein from Sheep)
- B8 (Protein from Sheep)
- B14.5b (Protein from Sheep)
- Cox7b (Protein from Sheep)
- 42 kda (Protein from Sheep)
- B9 (Protein from Sheep)
- B13 (Protein from Sheep)
- Cox6c (Protein from Sheep)
- Sdap (Protein from Sheep)
- Complex iii core 1 (Protein from Sheep)
- Complex iii 14 kda (Protein from Sheep)
- Complex iii cytochrome b (Protein from Sheep)
- B14.5a (Protein from Sheep)
- Mnll (Protein from Sheep)
- 15 kda (Protein from Sheep)
- Esss (Protein from Sheep)
- Sgdh (Protein from Sheep)
- Pdsw (Protein from Sheep)
- 10 kda (Protein from Sheep)
- Ovine respiratory supercomplex (i-iii2-iv), conformation loose (1 MDa, Complex from Ovis aries)
- Complex iii core 2 (Protein from Sheep)
- Nd6 (Protein from Sheep)
- Tyky (Protein from Sheep)
- Nd2 (Protein from Sheep)
- Complex iii qp-c (Protein from Sheep)
- 13 kda (Protein from Sheep)
- 39 kda (Protein from Sheep)
- Nd4 (Protein from Sheep)
- Complex iii cytochrome c1 (Protein from Sheep)
- Mwfe (Protein from Sheep)
- B14.7 (Protein from Sheep)
- 75 kda (Protein from Sheep)
- Cox2 (Protein from Sheep)
- Complex iii rieske (Protein from Sheep)
- B17.2 (Protein from Sheep)
- Nd3 (Protein from Sheep)
- B12 (Protein from Sheep)
- Pgiv (Protein from Sheep)
- Complex iii 8 kda (Protein from Sheep)
- 30 kda (Protein from Sheep)
- Cox6b1 (Protein from Sheep)
- Cox5a (Protein from Sheep)
- B16.6 (Protein from Sheep)
- B22 (Protein from Sheep)
- Psst (Protein from Sheep)
- Complex iii 7.2 kda (Protein from Sheep)
- Complex iii 11 kda (Protein from Sheep)
- 18 kda (Protein from Sheep)
- Aggg (Protein from Sheep)
- Nd1 (Protein from Sheep)
- Nd4l (Protein from Sheep)
- Cox7c (Protein from Sheep)
- B17 (Protein from Sheep)
- B14 (Protein from Sheep)
- Respiratory complex i (Complex from Ovis aries)
- Respiratory complex iv (Complex from Ovis aries)
- Cox4 (Protein from Sheep)
- Ashi (Protein from Sheep)
- B18 (Protein from Sheep)
- Complex iii 6.4 kda (Protein from Sheep)
- 49 kda (Protein from Sheep)
- Nd5 (Protein from Sheep)
- Cox1 (Protein)
- Cox6a2 (Protein from Sheep)
- 51 kda (Protein from Sheep)