Cryo-EM structure of the human 39S mitoribosome with Tigecycline
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8k2b
Q-score: 0.477
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ DOI: doi:10.1038/s41467-024-49797-7 Pubmed: 38942792 ]
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- 4'-phosphopantetheine (358 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Mitochondrial ribosome and complex i assembly factor altmief1 (8 kDa, Protein from Homo sapiens)
- 55s mitoribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xt1
Q-score: 0.472
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ DOI: doi:10.1038/s41467-024-49797-7 Pubmed: 38942792 ]
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xt3
Q-score: 0.467
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ DOI: doi:10.1038/s41467-024-49797-7 Pubmed: 38942792 ]
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
human mitoribosomal large subunit assembly intermediate 1 with GTPBP10-GTPBP7
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8pk0
Q-score: 0.455
Nat Commun (2023) 14 pp. 7991-7991 [ DOI: doi:10.1038/s41467-023-43599-z Pubmed: 38042949 ]
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- 5-methylcytosine rrna methyltransferase nsun4 (43 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Homo sapiens)
- Mief1 upstream open reading frame protein (8 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Transcription termination factor 4, mitochondrial (44 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- S-(2-{[n-(2-hydroxy-4-{[hydroxy(oxido)phosphino]oxy}-3,3-dimethylbutanoyl)-beta-alanyl]amino}ethyl) decanethioate (496 Da, Ligand)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- Cp trna-val (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l33, mitochondrial (7 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- Gtp-binding protein 10 (42 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- Large mitoribosomal subunit biogenesis intermediate with gtpbp10, gtpbp7, nsun4-mterf4, acp-module (1 MDa, Complex from Homo sapiens)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l46, mitochondrial (31 kDa, Protein from Homo sapiens)
- Mitochondrial ribosome-associated gtpase 1 (37 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)
- 16s rrna + pre-h68-71 segment (509 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l48, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l40, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)
Streptomycin bound to the 30S body
Resolution: 1.79 Å
EM Method: Single-particle
Fitted PDBs: 8cgj
Q-score: 0.729
Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmuller H, Novacek J, Wilson DN
Nat Struct Mol Biol (2023) 30 pp. 1380-1392 [ Pubmed: 37550453 DOI: doi:10.1038/s41594-023-01047-y ]
- 30s ribosomal protein s16 (9 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Escherichia coli BW25113)
- 70s ribosomes with antibiotic cocktail (Complex from Escherichia coli BW25113)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Escherichia coli BW25113)
- Potassium ion (39 Da, Ligand)
- 30s ribosomal protein s2 (26 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us17 (9 kDa, Protein from Escherichia coli BW25113)
- Tetracycline (444 Da, Ligand)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Escherichia coli BW25113)
- Water (18 Da, Ligand)
- Small ribosomal subunit protein us12 (13 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein bs21 (8 kDa, Protein from Escherichia coli BW25113)
- 16s rrna (499 kDa, RNA from Escherichia coli BW25113)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein bs6, non-modified isoform (15 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Escherichia coli BW25113)
- 30s ribosomal protein s20 (9 kDa, Protein from Escherichia coli BW25113)
- [(2~{s},3~{s},4~{s},5~{r},6~{s})-2-[(2~{r},3~{r},4~{r},5~{s})-2-[(1~{r},2~{s},3~{r},4~{r},5~{s},6~{r})-2,4-bis[[azaniumylidene(azanyl)methyl]amino]-3,5,6-tris(oxidanyl)cyclohexyl]oxy-4-[bis(oxidanyl)methyl]-5-methyl-4-oxidanyl-oxolan-3-yl]oxy-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-3-yl]-methyl-azanium (602 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 23s rrna (941 kDa, RNA from Escherichia coli BW25113)
Apramycin bound to the 30S body
Resolution: 2.12 Å
EM Method: Single-particle
Fitted PDBs: 8cgr
Q-score: 0.722
Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmuller H, Novacek J, Wilson DN
Nat Struct Mol Biol (2023) 30 pp. 1380-1392 [ Pubmed: 37550453 DOI: doi:10.1038/s41594-023-01047-y ]
- 30s ribosomal protein s16 (9 kDa, Protein from Escherichia coli BW25113)
- Apramycin (539 Da, Ligand)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Escherichia coli BW25113)
- 70s ribosomes with antibiotic cocktail (Complex from Escherichia coli BW25113)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Escherichia coli BW25113)
- Potassium ion (39 Da, Ligand)
- Small ribosomal subunit protein us17 (9 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Escherichia coli BW25113)
- Water (18 Da, Ligand)
- Small ribosomal subunit protein us12 (13 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein bs21 (8 kDa, Protein from Escherichia coli BW25113)
- 16s rrna (499 kDa, RNA from Escherichia coli BW25113)
- Small ribosomal subunit protein bs6, non-modified isoform (15 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Escherichia coli BW25113)
- 30s ribosomal protein s20 (9 kDa, Protein from Escherichia coli BW25113)
- Magnesium ion (24 Da, Ligand)
- 23s rrna (941 kDa, RNA from Escherichia coli BW25113)
Gentamicin bound to the 30S body
Resolution: 1.89 Å
EM Method: Single-particle
Fitted PDBs: 8cgu
Q-score: 0.76
Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmuller H, Novacek J, Wilson DN
Nat Struct Mol Biol (2023) 30 pp. 1380-1392 [ Pubmed: 37550453 DOI: doi:10.1038/s41594-023-01047-y ]
- 30s ribosomal protein s16 (9 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Escherichia coli BW25113)
- 70s ribosomes with antibiotic cocktail (Complex from Escherichia coli BW25113)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Escherichia coli BW25113)
- Potassium ion (39 Da, Ligand)
- Small ribosomal subunit protein us17 (9 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Escherichia coli BW25113)
- Water (18 Da, Ligand)
- Small ribosomal subunit protein us12 (13 kDa, Protein from Escherichia coli BW25113)
- (2r,3r,4r,5r)-2-((1s,2s,3r,4s,6r)-4,6-diamino-3-((2r,3r,6s)-3-amino-6-(aminomethyl)-tetrahydro-2h-pyran-2-yloxy)-2-hydr oxycyclohexyloxy)-5-methyl-4-(methylamino)-tetrahydro-2h-pyran-3,5-diol (449 Da, Ligand)
- Small ribosomal subunit protein bs21 (8 kDa, Protein from Escherichia coli BW25113)
- 16s rrna (499 kDa, RNA from Escherichia coli BW25113)
- Small ribosomal subunit protein bs6, non-modified isoform (15 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Escherichia coli BW25113)
- 30s ribosomal protein s20 (9 kDa, Protein from Escherichia coli BW25113)
- Magnesium ion (24 Da, Ligand)
- 23s rrna (941 kDa, RNA from Escherichia coli BW25113)
Kasugamycin bound to the 30S body
Resolution: 2.04 Å
EM Method: Single-particle
Fitted PDBs: 8cep
Q-score: 0.734
Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmuller H, Novacek J, Wilson DN
Nat Struct Mol Biol (2023) 30 pp. 1380-1392 [ DOI: doi:10.1038/s41594-023-01047-y Pubmed: 37550453 ]
- Small ribosomal subunit protein bs21 (8 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein bs6, non-modified isoform (15 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Escherichia coli BW25113)
- (1s,2r,3s,4r,5s,6s)-2,3,4,5,6-pentahydroxycyclohexyl 2-amino-4-{[carboxy(imino)methyl]amino}-2,3,4,6-tetradeoxy-alpha-d-arabino-hexopyranoside (379 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- 70s ribosomes with antibiotic cocktail (Complex from Escherichia coli BW25113)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Escherichia coli BW25113)
- 30s ribosomal protein s16 (9 kDa, Protein from Escherichia coli BW25113)
- 23s rrna (941 kDa, RNA from Escherichia coli BW25113)
- Water (18 Da, Ligand)
- Capreomycin ia (686 Da, Protein from Streptomyces californicus)
- Small ribosomal subunit protein us17 (9 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us12 (13 kDa, Protein from Escherichia coli BW25113)
- Magnesium ion (24 Da, Ligand)
- 30s ribosomal protein s20 (9 kDa, Protein from Escherichia coli BW25113)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Escherichia coli BW25113)
- 16s rrna (499 kDa, RNA from Escherichia coli BW25113)
39S human mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8oit
Q-score: 0.491
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schonhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarcic T, Kummer E, Gatfield D, Filipovska A, Ban N
Science (2023) 380 pp. 531-536 [ Pubmed: 37141370 DOI: doi:10.1126/science.adf9890 ]
- 39s human mitochondrial ribosome with mtrf1 and p-site trna (50 kDa, Complex from Homo sapiens)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l36, mitochondrial (11 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l33, mitochondrial (7 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- Fe-s-o hybrid cluster (335 Da, Ligand)
- 39s ribosomal protein l1, mitochondrial (36 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- P-site met-trna(met) (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l46, mitochondrial (31 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- E-site trna (894 Da, RNA from Homo sapiens)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l48, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l12, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l40, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- Peptide chain release factor 1, mitochondrial (56 kDa, Protein from Homo sapiens)
- Valine (117 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Methionine (149 Da, Ligand)
- Cp val-trna(val) (22 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 1
Resolution: 5.7 Å
EM Method: Single-particle
Fitted PDBs: 7oi6
Q-score: 0.28
Cheng J, Berninghausen O, Beckmann R
Nat Commun (2021) 12 pp. 4544-4544 [ Pubmed: 34315873 DOI: doi:10.1038/s41467-021-24818-x ]
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- Mief1 upstream open reading frame protein (8 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l43, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- Rrna methyltransferase 3, mitochondrial (47 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
- Human 39s mitoribosome assembly intermediates, state 1 (Complex from Homo sapiens)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- Gtp-binding protein 10 (42 kDa, Protein from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- Mitochondrial val trna (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- 4'-phosphopantetheine (358 Da, Ligand)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx28 (59 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)