Thermoplasma acidophilum 20S proteasome - alphaV24Y
Resolution: 2.38 Å
EM Method: Single-particle
Fitted PDBs: 9buz
Q-score: 0.567
Chuah JJY, Daugherty MR, Smith DM
bioRxiv (2024) [ DOI: doi:10.1101/2024.05.21.595185 Pubmed: 38826226 ]
- Water (18 Da, Ligand)
- Thermoplasma acidophilum 20s proteasome alphav24y (700 MDa, Complex from Thermoplasma acidophilum)
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit beta (23 kDa, Protein from Thermoplasma acidophilum)
Resolution: 2.02 Å
EM Method: Single-particle
Fitted PDBs: 8rvq
Q-score: 0.659
Mark E, Ramos PC, Kayser F, Hockendorff J, Dohmen RJ, Wendler P
Life Sci Alliance (2024) 7 [ Pubmed: 39260885 DOI: doi:10.26508/lsa.202402865 ]
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (24 kDa, Protein from Saccharomyces cerevisiae)
- 20s proteasome from pre1-1 (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae)
- Water (18 Da, Ligand)
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-2 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae)
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae)
Blm10-20S proteasome complex from pre1-1
Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 9gbk
Q-score: 0.585
Mark E, Ramos PC, Kayser F, Hockendorff J, Dohmen RJ, Wendler P
Life Sci Alliance (2024) 7 [ Pubmed: 39260885 DOI: doi:10.26508/lsa.202402865 ]
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae)
- Blm10-20s proteasome complex from pre1-1 (Complex)
- Proteasome subunit beta type-2 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae)
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (24 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome activator blm10 (246 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae)
- 20s proteasome core (Complex from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae)
canine immunoproteasome 20S subunit in complex with compound 1
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8yvp
Q-score: 0.64
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Threonine (119 Da, Ligand)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-7 (25 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Mus musculus)
- 20s proteasome (Complex from Mus musculus)
- [(~{r})-cyclohexyl-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]methyl]boronic acid (334 Da, Ligand)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-6 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-5 (22 kDa, Protein from Mus musculus)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8oix
Q-score: 0.581
Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E
Nat Commun (2024) 15 pp. 8621-8621 [ DOI: doi:10.1038/s41467-024-53022-w Pubmed: 39366995 ]
- Proteasome subunit beta (21 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (25 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (25 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (23 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (27 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome beta subunit, threonine peptidase (26 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (27 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (21 kDa, Protein from Trichomonas vaginalis G3)
- (3ar,6r,6as)-6-((s)-((s)-cyclohex-2-enyl)(hydroxy)methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[3,2-c]pyrrole-6-carbaldehyde (279 Da, Ligand)
- Proteasome subunit beta (22 kDa, Protein from Trichomonas vaginalis G3)
- Ternary complex of 20s proteasome from trichomonas vaginalis (704 kDa, Complex from Trichomonas vaginalis G3)
- Proteasome subunit beta (25 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (26 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (27 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (26 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome endopeptidase complex (26 kDa, Protein from Trichomonas vaginalis G3)
Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8g6e
Q-score: 0.715
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (23 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (30 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum NF54)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
- Plasmodium falciparum 20s proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Water (18 Da, Ligand)
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g6f
Q-score: 0.645
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-2 (25 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-5 (23 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-3 (24 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-4 (22 kDa, Protein from Plasmodium falciparum Dd2)
- The plasmodium falciparum 20s proteasome beta-6 a117d mutant complexed with inhibitor wlw-vs (700 kDa, Complex from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-4 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-6 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum Dd2)
- (2s)-n-[(e,2s)-1-(1h-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2s)-3-(1h-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide (690 Da, Ligand)
- Water (18 Da, Ligand)
- Proteasome subunit beta-7 (30 kDa, Protein from Plasmodium falciparum Dd2)
Human PA200-20S proteasome complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7naq
Q-score: 0.483
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Pa200-20s proteasome complex (Complex from Homo sapiens)
- Proteasome activator complex subunit 4 (211 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human PA200-20S proteasome with MG-132
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8cvs
Q-score: 0.559
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome activator complex subunit 4 (211 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- N-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide (475 Da, Ligand)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Proteasome subunit beta type-7 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Pa200-20s proteasome (Complex from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human 19S-20S proteasome, state SD2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8cvt
Q-score: 0.376
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
- Human 19s-20s proteasome (Complex from Homo sapiens)
- N-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide (475 Da, Ligand)
- 26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)