Thermoplasma acidophilum 20S proteasome - alphaV24Y
Resolution: 2.38 Å
EM Method: Single-particle
Fitted PDBs: 9buz
Q-score: 0.567
Chuah JJY, Daugherty MR, Smith DM
bioRxiv (2024) [ DOI: doi:10.1101/2024.05.21.595185 Pubmed: 38826226 ]
- Water (18 Da, Ligand)
- Thermoplasma acidophilum 20s proteasome alphav24y (700 MDa, Complex from Thermoplasma acidophilum)
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit beta (23 kDa, Protein from Thermoplasma acidophilum)
Resolution: 2.02 Å
EM Method: Single-particle
Fitted PDBs: 8rvq
Q-score: 0.659
Mark E, Ramos PC, Kayser F, Hockendorff J, Dohmen RJ, Wendler P
Life Sci Alliance (2024) 7 [ Pubmed: 39260885 DOI: doi:10.26508/lsa.202402865 ]
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (24 kDa, Protein from Saccharomyces cerevisiae)
- 20s proteasome from pre1-1 (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae)
- Water (18 Da, Ligand)
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-2 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae)
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae)
Blm10-20S proteasome complex from pre1-1
Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 9gbk
Q-score: 0.585
Mark E, Ramos PC, Kayser F, Hockendorff J, Dohmen RJ, Wendler P
Life Sci Alliance (2024) 7 [ Pubmed: 39260885 DOI: doi:10.26508/lsa.202402865 ]
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae)
- Blm10-20s proteasome complex from pre1-1 (Complex)
- Proteasome subunit beta type-2 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae)
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (24 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome activator blm10 (246 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae)
- 20s proteasome core (Complex from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae)
canine immunoproteasome 20S subunit in complex with compound 1
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8yvp
Q-score: 0.64
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Threonine (119 Da, Ligand)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-7 (25 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Mus musculus)
- 20s proteasome (Complex from Mus musculus)
- [(~{r})-cyclohexyl-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]methyl]boronic acid (334 Da, Ligand)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-6 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-5 (22 kDa, Protein from Mus musculus)
Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8g6e
Q-score: 0.715
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (23 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (30 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum NF54)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
- Plasmodium falciparum 20s proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Water (18 Da, Ligand)
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g6f
Q-score: 0.645
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-2 (25 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-5 (23 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-3 (24 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-4 (22 kDa, Protein from Plasmodium falciparum Dd2)
- The plasmodium falciparum 20s proteasome beta-6 a117d mutant complexed with inhibitor wlw-vs (700 kDa, Complex from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-4 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-6 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum Dd2)
- (2s)-n-[(e,2s)-1-(1h-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2s)-3-(1h-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide (690 Da, Ligand)
- Water (18 Da, Ligand)
- Proteasome subunit beta-7 (30 kDa, Protein from Plasmodium falciparum Dd2)
Human PA200-20S proteasome complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7naq
Q-score: 0.483
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Pa200-20s proteasome complex (Complex from Homo sapiens)
- Proteasome activator complex subunit 4 (211 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human PA200-20S proteasome with MG-132
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8cvs
Q-score: 0.559
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome activator complex subunit 4 (211 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- N-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide (475 Da, Ligand)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Proteasome subunit beta type-7 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Pa200-20s proteasome (Complex from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human 19S-20S proteasome, state SD2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8cvt
Q-score: 0.376
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
- Human 19s-20s proteasome (Complex from Homo sapiens)
- N-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide (475 Da, Ligand)
- 26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Structure of Plasmodium falciparum 20S proteasome with bound bortezomib.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7lxt
Q-score: 0.498
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum)
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- Plasmodium falciparum 20s proteasome complexed with bortezomib (700 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))