Phosphorylated human NKCC1 in complex with bumetanide
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9c0h
Q-score: 0.602
Zhao Y, Vidossich P, Forbush B, Ma J, Rinehart J, De Vivo M, Cao E
EMBO J (2025) [ Pubmed: 39875725 DOI: doi:10.1038/s44318-025-00368-6 ]
- Phosphorylated human nkcc1 in complex with bumetanide (Complex from Homo sapiens)
- Solute carrier family 12 member 2 (131 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid (364 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Microtubule plus end architecture in presence of the ciliary tip module.
Saunders HAJ, van den Berg CM, Hoogebeen RA, Schweizer D, Stecker KE, Roepman R, Howes SC, Akhmanova A
Nat Struct Mol Biol (2025) [ Pubmed: 39856351 DOI: doi:10.1038/s41594-025-01483-y ]
- Microtubules with sub-stoichiometric eb3 and the ciliary tip module (Complex)
- Cep104 (Cellular component from Homo sapiens)
- Ccdc66 (Cellular component from Homo sapiens)
- Eb3 (Cellular component from Homo sapiens)
- Armc9 (Cellular component from Homo sapiens)
- Tubulin (Cellular component from Sus scrofa domesticus)
- Togaram1 (Cellular component from Mus musculus)
- Cspp1 (Cellular component from Homo sapiens)
Structure of the IFN-lambda3/IFN-lambdaR1/IL-10Rbeta receptor complex with an engineered IL-10Rbeta
Grubbe WS, Zhang B, Kauffman A, Bylehn F, Padol K, Jung HG, Park SB, Priest JM, Ozkan E, de Pablo JJ, Liang TJ, Zhao M, Mendoza JL
Nat Commun (2025) 16 pp. 818-818 [ DOI: doi:10.1038/s41467-025-56119-y Pubmed: 39827213 ]
- Structure of the ifn-lambda3/ifn-lambdar1/il-10rbeta receptor complex with an engineered il-10rbeta (71 kDa, Complex from Homo sapiens)
- Interleukin-10 receptor subunit beta (24 kDa, Protein from Homo sapiens)
- Interferon lambda-3 (19 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interferon lambda receptor 1 (23 kDa, Protein from Homo sapiens)
Structure of GGCX-BGP-menaquinone-4 epoxide complex
Wang R, Chen B, Elghobashi-Meinhardt N, Tie JK, Ayala A, Zhou N, Qi X
Nature (2025) [ DOI: doi:10.1038/s41586-024-08484-9 Pubmed: 39880952 ]
- Vitamin k-dependent gamma-carboxylase (88 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Osteocalcin (11 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ggcx-bgp-menaquinone-4 epoxide complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1ar,7as)-1a-methyl-7a-[(2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione (460 Da, Ligand)
Modifying region of EcPKS2 - acetylated dataset
Schubert HL, Li F, Hill CP, Schmidt EW
PNAS (2025) 122 pp. e2419884122-e2419884122 [ DOI: doi:10.1073/pnas.2419884122 Pubmed: 39913209 ]
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Ecpks2 (350 kDa, Complex from Elysia chlorotica)
- Polyketide synthase 2 (252 kDa, Protein from Elysia chlorotica)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] ethanethioate (400 Da, Ligand)
Full length EcPKS2 - acylated dataset with three ACP positions
Schubert HL, Li F, Hill CP, Schmidt EW
PNAS (2025) 122 pp. e2419884122-e2419884122 [ DOI: doi:10.1073/pnas.2419884122 Pubmed: 39913209 ]
- Homodimer of ecpks2 (350 kDa, Complex from Elysia chlorotica)
- Polyketide synthase 2 (253 kDa, Protein from Elysia chlorotica)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] ethanethioate (400 Da, Ligand)
Haspin bound to nucleosome in position 1
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9b2s
Q-score: 0.536
Hicks CW, Gliech CR, Zhang X, Rahman S, Vasquez S, Holland AJ, Wolberger C
To Be Published
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- Haspin bound to nucleosome (Complex from Xenopus laevis)
- Serine/threonine-protein kinase haspin (40 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- 601 dna (185-mer) (56 kDa, DNA from synthetic construct)
- 601 dna (185-mer) (57 kDa, DNA from synthetic construct)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
Haspin bound to nucleosome in position 2
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 9b2t
Q-score: 0.502
Hicks CW, Gliech CR, Zhang X, Rahman S, Vasquez S, Holland AJ, Wolberger C
To Be Published
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- Haspin bound to nucleosome (Complex from Xenopus laevis)
- Serine/threonine-protein kinase haspin (40 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- 601 dna (185-mer) (56 kDa, DNA from synthetic construct)
- 601 dna (185-mer) (57 kDa, DNA from synthetic construct)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 9b2u
Q-score: 0.363
Hicks CW, Gliech CR, Zhang X, Rahman S, Vasquez S, Holland AJ, Wolberger C
To Be Published
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Haspin bound to h3 tail (Complex from Xenopus laevis)
- Serine/threonine-protein kinase haspin (40 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9dx7
Q-score: 0.438
To Be Published
- Lrrc8a:d channel (620 kDa, Complex from Mus musculus)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8d (99 kDa, Protein from Mus musculus)