Serotonin 5A (5-HT5A) receptor-Gi protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7x5h
Q-score: 0.497
Tan Y, Xu P, Huang S, Yang G, Zhou F, He X, Ma H, Xu HE, Jiang Y
Cell Discov (2022) 8 pp. 50-50 [ DOI: doi:10.1038/s41421-022-00412-3 Pubmed: 35610220 ]
- 5-ht5a-gi (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 5a,hydroxytryptamine receptor 5a (77 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 5-ht5a-gi-scfv16 complex (Complex from Homo sapiens)
- 3-(2-azanylethyl)-1h-indole-5-carboxamide (203 Da, Ligand)
Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xtc
Q-score: 0.455
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE
Mol Cell (2022) 82 pp. 2681-2695.e6 [ Pubmed: 35714614 DOI: doi:10.1016/j.molcel.2022.05.031 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 7 (64 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Serotonin 7 (5-ht7) receptor-gs-nb35 complex (Complex from Homo sapiens)
- 3-(2-azanylethyl)-1h-indole-5-carboxamide (203 Da, Ligand)
CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 7um5
Q-score: 0.591
Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL
Nat Struct Mol Biol (2022) 29 pp. 677-687 [ DOI: doi:10.1038/s41594-022-00796-6 Pubmed: 35835867 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Go-coupled 5-ht5ar complex (Complex)
- Single-chain variable fragment scfv16 (Complex from Mus musculus)
- 5-hydroxytryptamine receptor 5a (36 kDa, Protein from Homo sapiens)
- Single-chain variable fragment scfv16 (26 kDa, Protein from Mus musculus)
- 5-hydroxytryptamine receptor 5a, minigo protein, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Minigo protein (25 kDa, Protein from Homo sapiens)
- 3-(2-azanylethyl)-1h-indole-5-carboxamide (203 Da, Ligand)