Structure of LAT1-CD98hc-Fab170 in complex with JPH203, consensus map
Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 8kdd
Q-score: 0.432
To Be Published
- Fab170 (Complex from Mus musculus)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab170 heavy chain (24 kDa, Protein from Mus musculus)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Fab170 light chain (24 kDa, Protein from Mus musculus)
- Lat1-cd98hc-fab170 (173 kDa, Complex)
- Nanvuranlat (472 Da, Ligand)
- Lat1-cd98hc (Complex from Homo sapiens)
Structure of LAT1-CD98hc in complex with JPH203, focused on TMD
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8kdf
Q-score: 0.458
To Be Published
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Lat1-cd98hc-fab170 (173 kDa, Complex from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Nanvuranlat (472 Da, Ligand)
Structure of LAT1-CD98hc-Fab170 in complex with BCH, consensus map
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8kdg
Q-score: 0.424
To Be Published
- (1~{s},2~{r},4~{r})-2-azanylbicyclo[2.2.1]heptane-2-carboxylic acid (155 Da, Ligand)
- Fab170 (Complex from Mus musculus)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab170 heavy chain (24 kDa, Protein from Mus musculus)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Fab170 light chain (24 kDa, Protein from Mus musculus)
- Lat1-cd98hc-fab170 (173 kDa, Complex)
- Lat1-cd98hc (Complex from Homo sapiens)
Structure of LAT1-CD98hc in complex with BCH, focused on TMD
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8kdh
Q-score: 0.45
To Be Published
- (1~{s},2~{r},4~{r})-2-azanylbicyclo[2.2.1]heptane-2-carboxylic acid (155 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Lat1-cd98hc-fab170 (173 kDa, Complex from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
Structure of apo inward-open LAT1-CD98hc-Fab170 in nanodisc, consensus map
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8kdi
Q-score: 0.43
To Be Published
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Fab170 heavy chain (24 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lat1-cd98hc-fab170 (Complex)
- Fab170 (Complex from Mus musculus)
- Lat1-cd98hc (Complex from Homo sapiens)
- Fab170 light chain (24 kDa, Protein from Mus musculus)
Structure of apo inward-open LAT1-CD98h in nanodisc, focused on TMD
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8kdj
Q-score: 0.44
To Be Published
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Lat1-cd98hc-fab170 (173 kDa, Complex from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
Structure of LAT1-CD98hc in complex with L-Phe, focused on TMD
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8kdn
Q-score: 0.413
To Be Published
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Phenylalanine (165 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Lat1-cd98hc-fab170 (173 kDa, Complex from Homo sapiens)
Structure of LAT1-CD98hc in complex with melphalan, focused on TMD
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8kdo
Q-score: 0.417
To Be Published
- Lat1-cd98hc-fab170 (173 kDa, Complex from Homo sapiens)
- (2~{s})-2-azanyl-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid (305 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
Structure of apo outward-open LAT1-CD98h in nanodisc, focused on TMD
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8kdp
Q-score: 0.409
To Be Published
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
- Lat1-cd98hc-fab170 (173 kDa, Complex from Homo sapiens)
Overall structure of the LAT1-4F2hc bound with L-dopa
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8j8l
Q-score: 0.371
To Be Published
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Overall structure of the lat1-4f2hc bound with l-dopa (Complex from Homo sapiens)
- 3,4-dihydroxyphenylalanine (197 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)