Overall structure of Erastin-bound xCT-4F2hc complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7epz
Q-score: 0.486
Yan R, Xie E, Li Y, Li J, Zhang Y, Chi X, Hu X, Xu L, Hou T, Stockwell BR, Min J, Zhou Q, Wang F
Cell Res (2022) 32 pp. 687-690 [ Pubmed: 35352032 DOI: doi:10.1038/s41422-022-00642-w ]
- Cystine/glutamate transporter (57 kDa, Protein from Homo sapiens)
- 2-[(1s)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one (547 Da, Ligand)
- Overall structure of erastin-bound xct-4f2hc complex (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycero-3-phosphate (703 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
cryo EM map of the LAT1-4F2hc bound with JX-075
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dsk
Q-score: 0.541
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- (2~{s})-2-azanyl-7-(naphthalen-1-ylmethoxy)-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (347 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Lat1-4f2hc bound with jx-075 (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
cryo EM map of the LAT1-4F2hc bound with JX-078
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dsl
Q-score: 0.539
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- (2~{s})-2-azanyl-7-[(2-phenylphenyl)methoxy]-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (373 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lat1-4f2hc bound with jx-078 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
cryo EM map of the LAT1-4F2hc bound with JX-119
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7dsn
Q-score: 0.53
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- (2~{s})-2-azanyl-7-[[2-(1,3-benzoxazol-2-yl)phenyl]methoxy]-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (414 Da, Ligand)
- Lat1-4f2hc bound with jx-119 (Complex from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
cryo EM map of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7dsq
Q-score: 0.495
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lat1-4f2hc bound with 3,5-diiodo-l-tyrosine (Complex from Homo sapiens)
- 3,5-diiodotyrosine (432 Da, Ligand)
- Water (18 Da, Ligand)
The LAT2-4F2hc complex in complex with tryptophan
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7cmh
Q-score: 0.49
Yan R, Zhou J, Li Y, Lei J, Zhou Q
Cell Discov (2020) 6 pp. 82-82 [ Pubmed: 33298890 DOI: doi:10.1038/s41421-020-00207-4 ]
- Tryptophan (204 Da, Ligand)
- The lat2-4f2hc complex in complex with leucine (100 kDa, Complex from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Large neutral amino acids transporter small subunit 2 (60 kDa, Protein from Homo sapiens)
The LAT2-4F2hc complex in complex with leucine
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7cmi
Q-score: 0.398
Yan R, Zhou J, Li Y, Lei J, Zhou Q
Cell Discov (2020) 6 pp. 82-82 [ Pubmed: 33298890 DOI: doi:10.1038/s41421-020-00207-4 ]
- The lat2-4f2hc complex in complex with leucine (100 kDa, Complex from Homo sapiens)
- Leucine (131 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Large neutral amino acids transporter small subunit 2 (60 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
human LAT1-4F2hc complex incubated with JPH203
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6irs
Q-score: 0.457
Nature (2019) 568 pp. 127-130 [ DOI: doi:10.1038/s41586-019-1011-z Pubmed: 30867591 ]
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Human lat1-4f2hc complex incubated with jph203 (100 kDa, Complex from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
human LAT1-4F2hc complex bound with BCH
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6irt
Q-score: 0.452
Nature (2019) 568 pp. 127-130 [ DOI: doi:10.1038/s41586-019-1011-z Pubmed: 30867591 ]
- (1s,2s,4r)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (155 Da, Ligand)
- Human lat1-4f2hc complex bound with bch (100 kDa, Complex from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)