Overall structure of the LAT1-4F2hc bound with L-dopa
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8j8l
Q-score: 0.371
To Be Published
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Overall structure of the lat1-4f2hc bound with l-dopa (Complex from Homo sapiens)
- 3,4-dihydroxyphenylalanine (197 Da, Ligand)
Overall structure of the LAT1-4F2hc bound with tyrosine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ida
Q-score: 0.514
To Be Published
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Tyrosine (181 Da, Ligand)
- Overall structure of the lat1-4f2hc bound with tyrosine (Complex from Homo sapiens)
Overall structure of the LAT1-4F2hc bound with tryptophan
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8j8m
Q-score: 0.378
To Be Published
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- Overall structure of the lat1-4f2hc bound with tryptophan (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
Structure of human Asc1/CD98hc heteromeric amino acid transporter
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8qey
Q-score: 0.365
Rullo-Tubau J, Martinez-Molledo M, Bartoccioni P, Puch-Giner I, Arias A, Saen-Oon S, Stephan-Otto Attolini C, Artuch R, Diaz L, Guallar V, Errasti-Murugarren E, Palacin M, Llorca O
Nat Commun (2024) 15 pp. 2986-2986 [ DOI: doi:10.1038/s41467-024-47385-3 Pubmed: 38582862 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- Asc1/cd98hc (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Asc-type amino acid transporter 1 (56 kDa, Protein from Homo sapiens)
Human LAT2-4F2hc complex in the apo-state
Resolution: 3.98 Å
EM Method: Single-particle
Fitted PDBs: 7b00
Q-score: 0.434
Rodriguez CF, Escudero-Bravo P, Diaz L, Bartoccioni P, Garcia-Martin C, Gilabert JG, Boskovic J, Guallar V, Errasti-Murugarren E, Llorca O, Palacin M
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2113573118 Pubmed: 34848541 ]
- Human lat2 4f2hc complex in the apo state (Complex from Homo sapiens)
- Isoform 2 of 4f2 cell-surface antigen heavy chain (58 kDa, Protein from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Large neutral amino acids transporter small subunit 2 (58 kDa, Protein from Homo sapiens)
Consensus mutated xCT-CD98hc complex
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 7ccs
Q-score: 0.162
Oda K, Lee Y, Wiriyasermkul P, Tanaka Y, Takemoto M, Yamashita K, Nagamori S, Nishizawa T, Nureki O
Protein Sci (2020) 29 pp. 2398-2407 [ DOI: doi:10.1002/pro.3966 Pubmed: 33016372 ]
- Consensus mutated xct-cd98hc complex (120 kDa, Complex from Homo sapiens)
- Consensus mutated anionic amino acid transporter light chain, xc- system (55 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)