Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9f1b
Q-score: 0.475
Lentzsch AM, Yudin D, Gamerdinger M, Chandrasekar S, Rabl L, Scaiola A, Deuerling E, Ban N, Shan SO
Nature (2024) 633 pp. 718-724 [ DOI: doi:10.1038/s41586-024-07846-7 Pubmed: 39169182 ]
- Ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
- Human nata (Complex from Homo sapiens)
- Human nate with a gst tag (Complex from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l21 (18 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
- P-site trna (15 kDa, RNA from Oryctolagus cuniculus)
- Large ribosomal subunit protein el34 (13 kDa, Protein from Oryctolagus cuniculus)
- Glutathione s-transferase class-mu 26 kda isozyme,n-alpha-acetyltransferase 50 (46 kDa, Protein from Homo sapiens)
- 5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
- Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
- Ternary complex of a translating ribosome, nac and nata/e (3 MDa, Complex)
- Ribosomal protein ul30 (29 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el18 (21 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul2 (28 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s6 (28 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l30 (12 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul13 (23 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s9 (22 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l32 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s29 (6 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l22 (14 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Spermine (202 Da, Ligand)
- Large ribosomal subunit protein ul18 (34 kDa, Protein from Oryctolagus cuniculus)
- Spermidine (145 Da, Ligand)
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s13 (17 kDa, Protein from Oryctolagus cuniculus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ribosomal protein l24 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s8 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s5 (22 kDa, Protein from Oryctolagus cuniculus)
- 60s acidic ribosomal protein p0 (34 kDa, Protein from Oryctolagus cuniculus)
- 5s rrna (38 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s3 (31 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
- S10_plectin domain-containing protein (18 kDa, Protein from Oryctolagus cuniculus)
- N-alpha-acetyltransferase 10 (26 kDa, Protein from Homo sapiens)
- Ribosomal protein s27a (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l31 (14 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l39-like (6 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s2 (31 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l38 (8 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
- Water (18 Da, Ligand)
- 40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
- Human nac heterodimer (Complex from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Large ribosomal subunit protein el42 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l37a (10 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35a (12 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us9 (19 kDa, Protein from Oryctolagus cuniculus)
- Rabbit ribosome-nascent chain complex (Complex from Oryctolagus cuniculus)
- Unknown atom or ion (145 Da, Ligand)
- 40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
- Mrna (543 Da, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s4 (29 kDa, Protein from Oryctolagus cuniculus)
- N-alpha-acetyltransferase 15, nata auxiliary subunit (106 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein el13 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el28 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s3a (30 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
- Transcription factor btf3 (17 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein es26 (13 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul4 (46 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
- Ubiquitin-ribosomal protein el40 fusion protein (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s19 (16 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el20 (20 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35 (14 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul22 (21 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Oryctolagus cuniculus)
- Nascent chain (2 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s7 (47 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l7a (30 kDa, Protein from Oryctolagus cuniculus)
- Human nata/e complex (Complex)
- 40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
- Nascent polypeptide-associated complex subunit alpha (25 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 9f1c
Q-score: 0.371
Lentzsch AM, Yudin D, Gamerdinger M, Chandrasekar S, Rabl L, Scaiola A, Deuerling E, Ban N, Shan SO
Nature (2024) 633 pp. 718-724 [ DOI: doi:10.1038/s41586-024-07846-7 Pubmed: 39169182 ]
- Ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
- Human nate with a gst tag (Complex from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l21 (18 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
- P-site trna (15 kDa, RNA from Oryctolagus cuniculus)
- 5s rrna (38 kDa, RNA from Oryctolagus cuniculus)
- Glutathione s-transferase class-mu 26 kda isozyme,n-alpha-acetyltransferase 50 (46 kDa, Protein from Homo sapiens)
- 5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
- Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein ul30 (29 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
- Human nata complex (Complex from Homo sapiens)
- Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el18 (21 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el40 (14 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul2 (28 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s6 (28 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l30 (12 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
- Human methionine aminopeptidase 1 (Complex from Homo sapiens)
- Large ribosomal subunit protein ul13 (23 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s9 (22 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l32 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s29 (6 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l22 (14 kDa, Protein from Oryctolagus cuniculus)
- Spermine (202 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ul18 (34 kDa, Protein from Oryctolagus cuniculus)
- Spermidine (145 Da, Ligand)
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s13 (17 kDa, Protein from Oryctolagus cuniculus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ribosomal protein l24 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s8 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s5 (22 kDa, Protein from Oryctolagus cuniculus)
- Quaternary complex of a translating 80s ribosome, nac, metap1 and nata/e (3 MDa, Complex)
- 60s acidic ribosomal protein p0 (34 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s3 (31 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
- S10_plectin domain-containing protein (18 kDa, Protein from Oryctolagus cuniculus)
- Nac heterodimer (Complex from Homo sapiens)
- N-alpha-acetyltransferase 10 (26 kDa, Protein from Homo sapiens)
- Ribosomal protein s27a (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l31 (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
- Unknown atom or ion (Ligand)
- 60s ribosomal protein l34 (13 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l39-like (6 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l38 (8 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
- Water (18 Da, Ligand)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
- Inositol hexakisphosphate (660 Da, Ligand)
- Large ribosomal subunit protein el42 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l37a (10 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35a (12 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us9 (19 kDa, Protein from Oryctolagus cuniculus)
- Rabbit ribosome-nascent chain complex (Complex from Oryctolagus cuniculus)
- Nascent chain (2 kDa, Protein from Oryctolagus cuniculus)
- Mrna (543 Da, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s4 (29 kDa, Protein from Oryctolagus cuniculus)
- N-alpha-acetyltransferase 15, nata auxiliary subunit (106 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el13 (24 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el28 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s3a (30 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
- Transcription factor btf3 (17 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein es26 (13 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul4 (46 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s19 (16 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el20 (20 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35 (14 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul22 (21 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Oryctolagus cuniculus)
- Methionine aminopeptidase 1 (43 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (47 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l7a (30 kDa, Protein from Oryctolagus cuniculus)
- Human nata/e complex (Complex)
- 40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
- Nascent polypeptide-associated complex subunit alpha (25 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 9f1d
Q-score: 0.447
Lentzsch AM, Yudin D, Gamerdinger M, Chandrasekar S, Rabl L, Scaiola A, Deuerling E, Ban N, Shan SO
Nature (2024) 633 pp. 718-724 [ DOI: doi:10.1038/s41586-024-07846-7 Pubmed: 39169182 ]
- Ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
- Human nate with a gst tag (Complex from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l21 (18 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
- Glutathione s-transferase class-mu 26 kda isozyme,n-alpha-acetyltransferase 50,n-alpha-acetyltransferase 50 (46 kDa, Protein from Homo sapiens)
- P-site trna (15 kDa, RNA from Oryctolagus cuniculus)
- 5s rrna (38 kDa, RNA from Oryctolagus cuniculus)
- 5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
- Isoform 2 of huntingtin-interacting protein k (26 kDa, Protein from Homo sapiens)
- Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein ul30 (29 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul23 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
- Human nata complex (Complex from Homo sapiens)
- Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el18 (21 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul2 (28 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s6 (28 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l30 (12 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
- Human methionine aminopeptidase 1 (Complex from Homo sapiens)
- Large ribosomal subunit protein ul13 (23 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el8 (30 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s9 (22 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l32 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s29 (6 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l22 (14 kDa, Protein from Oryctolagus cuniculus)
- Spermine (202 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ul18 (34 kDa, Protein from Oryctolagus cuniculus)
- Spermidine (145 Da, Ligand)
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s13 (17 kDa, Protein from Oryctolagus cuniculus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ribosomal protein l24 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s8 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s5 (22 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s3 (31 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
- S10_plectin domain-containing protein (18 kDa, Protein from Oryctolagus cuniculus)
- N-alpha-acetyltransferase 10 (26 kDa, Protein from Homo sapiens)
- Ribosomal protein s27a (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l31 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
- Unknown atom or ion (Ligand)
- 60s ribosomal protein l34 (13 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l39-like (6 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l38 (8 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
- Water (18 Da, Ligand)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
- Human nac heterodimer (Complex from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Large ribosomal subunit protein el42 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l37a (10 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35a (12 kDa, Protein from Oryctolagus cuniculus)
- Human hypk (Complex from Homo sapiens)
- Nascent chain (2 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein us9 (19 kDa, Protein from Oryctolagus cuniculus)
- Rabbit ribosome-nascent chain complex (Complex from Oryctolagus cuniculus)
- Human nata/e-hypk complex (Complex)
- Mrna (543 Da, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s4 (29 kDa, Protein from Oryctolagus cuniculus)
- N-alpha-acetyltransferase 15, nata auxiliary subunit (106 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el13 (24 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el28 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s3a (30 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
- 18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein es26 (13 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
- Isoform 2 of transcription factor btf3 (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4 (46 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
- Ubiquitin-ribosomal protein el40 fusion protein (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
- Quaternary complex of a translating 80s ribosome, nac, metap1 and nata/e-hypk (3 MDa, Complex)
- 40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s19 (16 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein el20 (20 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35 (14 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul22 (21 kDa, Protein from Oryctolagus cuniculus)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Oryctolagus cuniculus)
- Large ribosomal subunit protein ul10 (34 kDa, Protein from Oryctolagus cuniculus)
- Methionine aminopeptidase 1 (43 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (47 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
- Nascent polypeptide-associated complex subunit alpha (25 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
Ternary complex of ribosome nascent chain with SRP and NAC
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7qwq
Q-score: 0.426
Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E
Science (2022) 375 pp. 839-844 [ DOI: doi:10.1126/science.abl6459 Pubmed: 35201867 ]
- Ribosomal protein l22 (11 kDa, Protein from Oryctolagus cuniculus)
- 5.8s ribosomal rna (50 kDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l7a (36 kDa, Protein from Oryctolagus cuniculus)
- Signal recognition particle proteins (Complex from Homo sapiens)
- Ribosomal protein l39 (6 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l13a (56 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l17 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35 (14 kDa, Protein from Oryctolagus cuniculus)
- Nascent chain preprolactin (Complex from Homo sapiens)
- Ul30 (26 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
- Srp rna 7sl (Complex from Homo sapiens)
- Ribosomal protein l24 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35a (12 kDa, Protein from Oryctolagus cuniculus)
- El18 (21 kDa, Protein from Oryctolagus cuniculus)
- Signal recognition particle subunit srp68 (70 kDa, Protein from Homo sapiens)
- El42 (16 kDa, Protein from Oryctolagus cuniculus)
- 5s ribosomal rna (38 kDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l38 (8 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from Oryctolagus cuniculus)
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- El43 (10 kDa, Protein from Oryctolagus cuniculus)
- L8 (26 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l32 (18 kDa, Protein from Oryctolagus cuniculus)
- Srp rna 7sl (54 kDa, RNA from Homo sapiens)
- Nascent chain preprolactin (9 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l30 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
- Nascent polypeptide-associated complex subunit alpha (23 kDa, Protein from Homo sapiens)
- Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
- Ubiquitin a-52 residue ribosomal protein fusion product 1 (14 kDa, Protein from Oryctolagus cuniculus)
- Signal recognition particle 19 kda protein (16 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l18a (20 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l28 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
- Signal recognition particle 54 kda protein (55 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l29 (24 kDa, Protein from Oryctolagus cuniculus)
- Ternary ribosome-nascent chain srp nac complex (Complex)
- Ribosome (Complex from Oryctolagus cuniculus)
- 60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (11 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
- Isoform 2 of transcription factor btf3 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l13 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l21 (18 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l31 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l34 (14 kDa, Protein from Oryctolagus cuniculus)
- Ul3 (46 kDa, Protein from Homo sapiens)
- Isoform 2 of transcription factor btf3 (Complex from Homo sapiens)
- Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qwr
Q-score: 0.454
Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E
Science (2022) 375 pp. 839-844 [ DOI: doi:10.1126/science.abl6459 Pubmed: 35201867 ]
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Ribosomal protein l32 (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l34 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l22 (12 kDa, Protein from Oryctolagus cuniculus)
- Isoform 2 of transcription factor btf3 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
- L13 (24 kDa, Protein from Oryctolagus cuniculus)
- El42 (16 kDa, Protein from Oryctolagus cuniculus)
- El43 (10 kDa, Protein from Oryctolagus cuniculus)
- 5.8s ribosomal rna (50 kDa, RNA from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
- Nascent chain pre-prolactin (Complex from Homo sapiens)
- 60s ribosomal protein l13a (56 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l31 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l28 (15 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l30 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l40 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l29 (24 kDa, Protein from Oryctolagus cuniculus)
- El18 (21 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l21 (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
- Ul30 (26 kDa, Protein from Oryctolagus cuniculus)
- Nascent chain pre-prolactin (2 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l38 (8 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l24 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35a (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l8 (26 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
- 5s ribosomal rna (38 kDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l35 (14 kDa, Protein from Oryctolagus cuniculus)
- Nascent polypeptide-associated complex subunit alpha (23 kDa, Protein from Homo sapiens)
- Isoform 2 of transcription factor btf3 (Complex from Homo sapiens)
- 60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l39 (6 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosome (Complex from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l17 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l18a (20 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from Oryctolagus cuniculus)
- Nascent polypeptide-associated complex subunit alpha (Complex from Homo sapiens)
- Ribosome-nascent chain containing an er signal sequence in complex with nac (Complex)
- 60s ribosomal protein l7a (36 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
Structure of ribosome translating beta-tubulin in complex with TTC5 and NAC
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7qws
Q-score: -0.054
Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E
Science (2022) 375 pp. 839-844 [ DOI: doi:10.1126/science.abl6459 Pubmed: 35201867 ]
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- Ribosomal protein l32 (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l34 (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosome translating beta-tubulin in complex with ttc5 and nac (Complex)
- Nascent chain tubulin beta (2 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
- El42 (16 kDa, Protein from Oryctolagus cuniculus)
- El43 (10 kDa, Protein from Oryctolagus cuniculus)
- 5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l31 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l28 (15 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l30 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l29 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l21 (18 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l13 (24 kDa, Protein from Oryctolagus cuniculus)
- Ul30 (26 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l40 (14 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l24 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l35a (12 kDa, Protein from Oryctolagus cuniculus)
- Nascent chain tubulin beta (Complex from Homo sapiens)
- 60s ribosomal protein l8 (26 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l13a (56 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l18a (20 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
- 5s rrna (38 kDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l35 (14 kDa, Protein from Oryctolagus cuniculus)
- Tetratricopeptide repeat protein 5 (Complex from Homo sapiens)
- Tetratricopeptide repeat protein 5 (48 kDa, Protein from Homo sapiens)
- Nascent polypeptide-associated complex subunit alpha (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l18 (21 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l39 (6 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosome (Complex from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l38 (8 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l17 (17 kDa, Protein from Oryctolagus cuniculus)
- Transcription factor btf3 (17 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Ribosomal protein l22 (12 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l7a (36 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)