Structure of Candida albicans 80S ribosome in complex with mefloquine
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ogj
Q-score: 0.366
Kolosova O, Zgadzay Y, Yusupov M
To Be Published
- 40s ribosomal protein s27 (8 kDa, Protein from Candida albicans)
- 60s ribosomal protein l11-b (19 kDa, Protein from Candida albicans)
- 40s ribosomal protein s6 (27 kDa, Protein from Candida albicans)
- 40s ribosomal protein s18-b (17 kDa, Protein from Candida albicans)
- 60s ribosomal protein l38 (8 kDa, Protein from Candida albicans)
- 40s ribosomal protein s1 (29 kDa, Protein from Candida albicans)
- Candida albicans 80s ribosome in complex with mefloquine (3 MDa, Complex from Candida albicans)
- 60s ribosomal protein l2-b (27 kDa, Protein from Candida albicans)
- Ribosomal protein s23 (s12) (16 kDa, Protein from Candida albicans)
- 40s ribosomal protein s10-a (13 kDa, Protein from Candida albicans)
- 40s ribosomal protein s0 (28 kDa, Protein from Candida albicans)
- 60s ribosomal protein l13 (23 kDa, Protein from Candida albicans)
- 60s ribosomal protein l41 (3 kDa, Protein from Candida albicans)
- Mixture of endogenous e-trnas (24 kDa, RNA from Candida albicans)
- 40s ribosomal protein s24 (15 kDa, Protein from Candida albicans)
- 60s ribosomal protein l24-a (17 kDa, Protein from Candida albicans)
- 40s ribosomal protein s25 (11 kDa, Protein from Candida albicans)
- 60s ribosomal protein l28 (16 kDa, Protein from Candida albicans)
- Zinc ion (65 Da, Ligand)
- 18s ribosomal rna (575 kDa, RNA from Candida albicans)
- 60s ribosomal protein l42-b (12 kDa, Protein from Candida albicans)
- 40s ribosomal protein s28-b (7 kDa, Protein from Candida albicans)
- 60s ribosomal protein l3 (44 kDa, Protein from Candida albicans)
- 60s ribosomal protein l29 (7 kDa, Protein from Candida albicans)
- 60s ribosomal protein l9-b (21 kDa, Protein from Candida albicans)
- Spermine (fully protonated form) (206 Da, Ligand)
- 60s ribosomal protein l14-b (14 kDa, Protein from Candida albicans)
- 40s ribosomal protein s8 (22 kDa, Protein from Candida albicans)
- 60s ribosomal protein l23-a (14 kDa, Protein from Candida albicans)
- 60s ribosomal protein l39 (6 kDa, Protein from Candida albicans)
- 60s ribosomal protein l36 (11 kDa, Protein from Candida albicans)
- (11r,12s)- mefloquine (378 Da, Ligand)
- 60s ribosomal protein l34-b (13 kDa, Protein from Candida albicans)
- 40s ribosomal protein s30 (7 kDa, Protein from Candida albicans)
- 60s ribosomal protein l27 (15 kDa, Protein from Candida albicans)
- 40s ribosomal protein s22-a (14 kDa, Protein from Candida albicans)
- 60s ribosomal protein l6 (19 kDa, Protein from Candida albicans)
- 60s ribosomal protein l37-b (10 kDa, Protein from Candida albicans)
- Ribosomal protein l29 (14 kDa, Protein from Candida albicans)
- 40s ribosomal protein s11a (17 kDa, Protein from Candida albicans)
- 40s ribosomal protein s21 (9 kDa, Protein from Candida albicans)
- 5s ribosomal rna (38 kDa, RNA from Candida albicans)
- 25s ribosomal rna (1 MDa, RNA from Candida albicans)
- 40s ribosomal protein s12 (15 kDa, Protein from Candida albicans)
- Guanine nucleotide-binding protein subunit beta-like protein (34 kDa, Protein from Candida albicans)
- 40s ribosomal protein s14-a (14 kDa, Protein from Candida albicans)
- Ubiquitin-40s ribosomal protein s31 fusion protein (22 kDa, Protein from Candida albicans)
- 60s ribosomal protein l20 (20 kDa, Protein from Candida albicans)
- 60s ribosomal protein l33-a (12 kDa, Protein from Candida albicans)
- 60s ribosomal protein l5 (34 kDa, Protein from Candida albicans)
- 60s ribosomal protein l25 (15 kDa, Protein from Candida albicans)
- Ribosomal protein s5 (26 kDa, Protein from Candida albicans)
- 40s ribosomal protein s16 (15 kDa, Protein from Candida albicans)
- 60s ribosomal protein l7-a (27 kDa, Protein from Candida albicans)
- 40s ribosomal protein s7 (21 kDa, Protein from Candida albicans)
- Ribosomal protein s4 (21 kDa, Protein from Candida albicans)
- Ribosomal protein l24 (14 kDa, Protein from Candida albicans)
- 40s ribosomal protein s19-a (16 kDa, Protein from Candida albicans)
- Ribosomal protein s7 (25 kDa, Protein from Candida albicans)
- Magnesium ion (24 Da, Ligand)
- 40s ribosomal protein s29a (6 kDa, Protein from Candida albicans)
- 60s ribosomal protein l19-a (21 kDa, Protein from Candida albicans)
- Ribosomal protein s3 (27 kDa, Protein from Candida albicans)
- 60s ribosomal protein l31-b (12 kDa, Protein from Candida albicans)
- 60s ribosomal protein l15-a (24 kDa, Protein from Candida albicans)
- 60s ribosomal protein l21-a (18 kDa, Protein from Candida albicans)
- Ribosomal protein l22 (21 kDa, Protein from Candida albicans)
- 40s ribosomal protein s13 (16 kDa, Protein from Candida albicans)
- 60s ribosomal protein l18-a (20 kDa, Protein from Candida albicans)
- 60s ribosomal protein l32 (14 kDa, Protein from Candida albicans)
- 60s ribosomal protein l4-b (39 kDa, Protein from Candida albicans)
- 60s ribosomal protein l22-b (14 kDa, Protein from Candida albicans)
- 60s ribosomal protein l40-b (6 kDa, Protein from Candida albicans)
- 60s ribosomal protein l10 (25 kDa, Protein from Candida albicans)
- 60s ribosomal protein l43-a (10 kDa, Protein from Candida albicans)
- Ribosomal protein s10 (13 kDa, Protein from Candida albicans)
- 40s ribosomal protein s26 (13 kDa, Protein from Candida albicans)
- 40s ribosomal protein s4 (29 kDa, Protein from Candida albicans)
- Ribosomal protein l13 (22 kDa, Protein from Candida albicans)
- 40s ribosomal protein s15 (15 kDa, Protein from Candida albicans)
- 40s ribosomal protein s17-b (15 kDa, Protein from Candida albicans)
- 5.8s ribosomal rna (50 kDa, RNA from Candida albicans)
- 60s ribosomal protein l8 (28 kDa, Protein from Candida albicans)
- 60s ribosomal protein l30 (11 kDa, Protein from Candida albicans)
Cryo-EM structure of the Xenopus egg 80S ribosome
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7oyc
Q-score: 0.557
Leesch F, Lorenzo-Orts L, Pribitzer C, Grishkovskaya I, Roehsner J, Chugunova A, Matzinger M, Roitinger E, Belacic K, Kandolf S, Lin TY, Mechtler K, Meinhart A, Haselbach D, Pauli A
Nature (2023) 613 pp. 712-720 [ Pubmed: 36653451 DOI: doi:10.1038/s41586-022-05623-y ]
- Eef2-prov protein (95 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s28 (7 kDa, Protein from Xenopus laevis)
- Eukaryotic translation initiation factor 5a (16 kDa, Protein from Xenopus laevis)
- Rpl5-b protein (34 kDa, Protein from Xenopus laevis)
- Rpl37a (10 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s25 (13 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s3a-a (29 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s13 (17 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s9 (22 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s11 (18 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s15a (14 kDa, Protein from Xenopus laevis)
- Rps16 protein (16 kDa, Protein from Xenopus laevis)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l19 (23 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l40 (14 kDa, Protein from Xenopus laevis)
- Ribosomal protein l15 (24 kDa, Protein from Xenopus laevis)
- 5s rrna (38 kDa, RNA from Xenopus laevis)
- Mgc116452 protein (6 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l6 (29 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l17 (21 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein sa (34 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s19 (16 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l35 (14 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l18a (20 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l30 (12 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l34 (13 kDa, Protein from Xenopus laevis)
- Trash domain-containing protein (17 kDa, Protein from Xenopus laevis)
- Mgc85428 protein (12 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s4 (29 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s27 (9 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s17 (15 kDa, Protein from Xenopus laevis)
- Rpl3-prov protein (46 kDa, Protein from Xenopus laevis)
- Habp4_pai-rbp1 domain-containing protein (42 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s26 (13 kDa, Protein from Xenopus laevis)
- Ribosomal_l18e/l15p domain-containing protein (21 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l35a (12 kDa, Protein from Xenopus laevis)
- 5.8s rrna (50 kDa, RNA from Xenopus laevis)
- Death-associated protein-like 1-b (12 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l7a (29 kDa, Protein from Xenopus laevis)
- Xenopus egg 80s ribosome (Complex from Xenopus laevis)
- 40s ribosomal protein s15 (17 kDa, Protein from Xenopus laevis)
- Ribosomal protein l37 (11 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l27 (15 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s21 (9 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s23 (15 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l22 (14 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s7 (22 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l36 (12 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l8 (27 kDa, Protein from Xenopus laevis)
- Dna-(apurinic or apyrimidinic site) lyase (27 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l38 (8 kDa, Protein from Xenopus laevis)
- Ribosomal_l16 domain-containing protein (24 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l28 (15 kDa, Protein from Xenopus laevis)
- Kow domain-containing protein (17 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s30 (14 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l9 (21 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s29 (10 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l14 (16 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l13a (26 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s24 (15 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s10 (18 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Ribosomal_s7 domain-containing protein (22 kDa, Protein from Xenopus laevis)
- Gnb2l1-prov protein (35 kDa, Protein from Xenopus laevis)
- 18s rrna (588 kDa, RNA from Xenopus laevis)
- 40s ribosomal protein s2 (30 kDa, Protein from Xenopus laevis)
- Rpl32 (15 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s18 (17 kDa, Protein from Xenopus laevis)
- Rpl41 (3 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l11 (20 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l31 (14 kDa, Protein from Xenopus laevis)
- 28s rrna (1 MDa, RNA from Xenopus laevis)
- 40s ribosomal protein s8 (24 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l4-b (45 kDa, Protein from Xenopus laevis)
- Mgc130910 protein (28 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l23 (14 kDa, Protein from Xenopus laevis)
- Rps14 (16 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l29 (8 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l13 (24 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s20 (13 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l21 (18 kDa, Protein from Xenopus laevis)
- 60s ribosomal protein l27a (16 kDa, Protein from Xenopus laevis)
- 40s ribosomal protein s6 (28 kDa, Protein from Xenopus laevis)