Cryo-EM structure of ribosome-Sec61-TRAP (TRanslocon Associated Protein) translocon complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8b5l
Q-score: 0.505
Pauwels E, Shewakramani NR, De Wijngaert B, Camps A, Provinciael B, Stroobants J, Kalies KU, Hartmann E, Maes P, Vermeire K, Das K
Sci Adv (2023) 9 pp. eadf0797-eadf0797 [ Pubmed: 36867692 DOI: doi:10.1126/sciadv.adf0797 ]
- 60s ribosomal protein l36 (12 kDa, Protein from rabbit)
- Ribosomal protein l3 (45 kDa, Protein from rabbit)
- Ribosomal_l23en domain-containing protein (13 kDa, Protein from rabbit)
- 60s ribosomal protein l38 (8 kDa, Protein from rabbit)
- 5.8s rrna (50 kDa, RNA from rabbit)
- 60s ribosomal protein l36a-like (12 kDa, Protein from rabbit)
- 60s ribosomal protein l30 (10 kDa, Protein from rabbit)
- Ribosomal protein l18 (21 kDa, Protein from rabbit)
- Ribosomal protein l37 (10 kDa, Protein from rabbit)
- 60s ribosomal protein l11 (19 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l27 (15 kDa, Protein from rabbit)
- 60s ribosomal protein l41 (3 kDa, Protein from rabbit)
- 80s ribosome complex with sec61 and trap (Complex from Canis lupus familiaris)
- Translocon-associated protein subunit alpha (32 kDa, Protein from Rabbit)
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l13a (23 kDa, Protein from rabbit)
- 5s rrna (38 kDa, RNA from rabbit)
- 60s ribosomal protein l13 (24 kDa, Protein from rabbit)
- Ribosomal protein l10 (24 kDa, Protein from rabbit)
- 60s ribosomal protein l29 (26 kDa, Protein from rabbit)
- 60s ribosomal protein l6 (33 kDa, Protein from rabbit)
- 60s ribosomal protein l27a (16 kDa, Protein from rabbit)
- 60s ribosomal protein l18a (20 kDa, Protein from rabbit)
- 60s ribosomal protein l23 (13 kDa, Protein from rabbit)
- 60s ribosomal protein l35a (12 kDa, Protein from rabbit)
- Translocon-associated protein subunit delta (18 kDa, Protein from Rabbit)
- Ribosomal protein l8 (28 kDa, Protein from rabbit)
- 60s ribosomal protein l22 (11 kDa, Protein from rabbit)
- Ribosomal protein l24 (17 kDa, Protein from rabbit)
- Ribosomal_l18_c domain-containing protein (34 kDa, Protein from rabbit)
- 60s ribosomal protein l37a (10 kDa, Protein from rabbit)
- 60s ribosomal protein l4 (41 kDa, Protein from rabbit)
- 60s ribosomal protein l31 (12 kDa, Protein from rabbit)
- 60s ribosomal protein l9 (21 kDa, Protein from rabbit)
- Protein transport protein sec61 subunit gamma (7 kDa, Protein from Rabbit)
- 60s ribosomal protein l7a (36 kDa, Protein from rabbit)
- 60s ribosomal protein l21 (18 kDa, Protein from rabbit)
- 60s ribosomal protein l14 (16 kDa, Protein from rabbit)
- Ribosomal protein l15 (24 kDa, Protein from rabbit)
- 60s ribosomal protein l7 (26 kDa, Protein from rabbit)
- 60s ribosomal protein l17 (17 kDa, Protein from rabbit)
- Protein transport protein sec61 subunit alpha isoform 1 (52 kDa, Protein from Rabbit)
- 60s ribosomal protein l39-like (6 kDa, Protein from rabbit)
- Ribosomal protein l32 (15 kDa, Protein from rabbit)
- 60s ribosomal protein l35 (14 kDa, Protein from rabbit)
- Ribosomal protein l26 (15 kDa, Protein from rabbit)
- Ubiquitin-60s ribosomal protein l40 (6 kDa, Protein from rabbit)
- Ribosomal protein l19 (23 kDa, Protein from rabbit)
- 60s ribosomal protein l28 (14 kDa, Protein from rabbit)
- Translocon-associated protein subunit beta (20 kDa, Protein from Rabbit)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l34 (12 kDa, Protein from rabbit)
- Signal sequence receptor subunit 3 (21 kDa, Protein from Rabbit)
Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8b6c
Q-score: 0.516
Pauwels E, Shewakramani NR, De Wijngaert B, Camps A, Provinciael B, Stroobants J, Kalies KU, Hartmann E, Maes P, Vermeire K, Das K
Sci Adv (2023) 9 pp. eadf0797-eadf0797 [ Pubmed: 36867692 DOI: doi:10.1126/sciadv.adf0797 ]
- 60s ribosomal protein l36 (12 kDa, Protein from rabbit)
- Ribosomal protein l3 (45 kDa, Protein from rabbit)
- Ribosomal_l23en domain-containing protein (13 kDa, Protein from rabbit)
- 5.8s rrna (50 kDa, RNA from rabbit)
- 60s ribosomal protein l38 (8 kDa, Protein from rabbit)
- 60s ribosomal protein l36a-like (12 kDa, Protein from rabbit)
- 60s ribosomal protein l30 (10 kDa, Protein from rabbit)
- 80s ribosome complex with sec61 and inhibitor ck147 (Complex from Canis lupus familiaris)
- Ribosomal protein l37 (10 kDa, Protein from rabbit)
- 60s ribosomal protein l11 (19 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l27 (15 kDa, Protein from rabbit)
- Protein transport protein sec61 subunit alpha isoform 1 (52 kDa, Protein from rabbit)
- 60s ribosomal protein l41 (3 kDa, Protein from rabbit)
- 28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l13a (23 kDa, Protein from rabbit)
- 5s rrna (38 kDa, RNA from rabbit)
- 60s ribosomal protein l13 (24 kDa, Protein from rabbit)
- 60s ribosomal protein l29 (26 kDa, Protein from rabbit)
- 60s ribosomal protein l6 (33 kDa, Protein from rabbit)
- 60s ribosomal protein l27a (16 kDa, Protein from rabbit)
- 60s ribosomal protein l18a (20 kDa, Protein from rabbit)
- 60s ribosomal protein l23 (13 kDa, Protein from rabbit)
- 60s ribosomal protein l35a (12 kDa, Protein from rabbit)
- 60s ribosomal protein l19 (23 kDa, Protein from rabbit)
- Ribosomal protein l8 (28 kDa, Protein from rabbit)
- Ribosomal protein l24 (17 kDa, Protein from rabbit)
- Ribosomal_l18_c domain-containing protein (34 kDa, Protein from rabbit)
- 60s ribosomal protein l37a (10 kDa, Protein from rabbit)
- 60s ribosomal protein l4 (41 kDa, Protein from rabbit)
- 60s ribosomal protein l31 (12 kDa, Protein from rabbit)
- 60s ribosomal protein l22 (fragment) (11 kDa, Protein from rabbit)
- Protein transport protein sec61 subunit gamma (7 kDa, Protein from Rabbit)
- 60s ribosomal protein l9 (21 kDa, Protein from rabbit)
- 60s ribosomal protein l7a (36 kDa, Protein from rabbit)
- 60s ribosomal protein l21 (18 kDa, Protein from rabbit)
- Ribosomal protein l15 (24 kDa, Protein from rabbit)
- 60s ribosomal protein l14 (16 kDa, Protein from rabbit)
- 60s ribosomal protein l7 (26 kDa, Protein from rabbit)
- El18 (21 kDa, Protein from rabbit)
- 60s ribosomal protein l17 (17 kDa, Protein from rabbit)
- 60s ribosomal protein l39-like (6 kDa, Protein from rabbit)
- Ribosomal protein l32 (15 kDa, Protein from rabbit)
- 60s ribosomal protein l40 (6 kDa, Protein from rabbit)
- 60s ribosomal protein l35 (14 kDa, Protein from rabbit)
- Ribosomal protein l26 (15 kDa, Protein from rabbit)
- 60s ribosomal protein l28 (14 kDa, Protein from rabbit)
- 4-[[9-(cyclohexylmethyl)-3-methylidene-5-(4-methylphenyl)sulfonyl-1,5,9-triazacyclododec-1-yl]sulfonyl]-~{n},~{n}-dimethyl-aniline (616 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l34 (12 kDa, Protein from rabbit)
- Ribosomal protein l10 (24 kDa, Protein from rabbit)