Rabbit 80S ribosome stalled on a poly(A) tail
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6sgc
Q-score: 0.575
Chandrasekaran V, Juszkiewicz S, Choi J, Puglisi JD, Brown A, Shao S, Ramakrishnan V, Hegde RS
Nat Struct Mol Biol (2019) 26 pp. 1132-1140 [ DOI: doi:10.1038/s41594-019-0331-x Pubmed: 31768042 ]
- Ribosomal_l7ae domain-containing protein (12 kDa, Protein from Rabbit)
- Ribosomal protein (24 kDa, Protein from Rabbit)
- Us5 (26 kDa, Protein from Rabbit)
- Us19 (17 kDa, Protein from Rabbit)
- 18s ribosomal rna (602 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s3a (30 kDa, Protein from Rabbit)
- Ribosomal protein s16 (16 kDa, Protein from Rabbit)
- Ribosome (Complex from Oryctolagus cuniculus)
- 40s ribosomal protein s7 (22 kDa, Protein from Rabbit)
- El33 (12 kDa, Protein from Rabbit)
- Ribosomal_l28e domain-containing protein (15 kDa, Protein from Rabbit)
- El31 (14 kDa, Protein from Rabbit)
- Polya mrna (3 kDa, RNA from Homo sapiens)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from Rabbit)
- El19 (23 kDa, Protein from Oryctolagus cuniculus)
- Trash domain-containing protein (17 kDa, Protein from Rabbit)
- Us2 (32 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l36 (12 kDa, Protein from Rabbit)
- Us5 (31 kDa, Protein from Oryctolagus cuniculus)
- Es21 (9 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l23 (14 kDa, Protein from Rabbit)
- El13 (24 kDa, Protein from Oryctolagus cuniculus)
- Ul30 (29 kDa, Protein from Rabbit)
- El20 (20 kDa, Protein from Oryctolagus cuniculus)
- El43 (10 kDa, Protein from Rabbit)
- Zinc ion (65 Da, Ligand)
- Es13 (17 kDa, Protein from Rabbit)
- Es19 (16 kDa, Protein from Rabbit)
- Ribosomal protein s15a (14 kDa, Protein from Rabbit)
- Us11 (18 kDa, Protein from Oryctolagus cuniculus)
- Us12 (15 kDa, Protein from Oryctolagus cuniculus)
- El22 (14 kDa, Protein from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Es24 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l12 (17 kDa, Protein from Rabbit)
- Es25 (13 kDa, Protein from Rabbit)
- 28s ribosomal rna (1 MDa, RNA from Oryctolagus cuniculus)
- Es26 (13 kDa, Protein from Oryctolagus cuniculus)
- El42 (12 kDa, Protein from Rabbit)
- Ribosomal_l18e/l15p domain-containing protein (16 kDa, Protein from Rabbit)
- S10_plectin domain-ontaining protein (18 kDa, Protein from Rabbit)
- Ul4 (47 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from Rabbit)
- Ribosomal protein l37 (11 kDa, Protein from Rabbit)
- Us14 (6 kDa, Protein from Rabbit)
- El39 (6 kDa, Protein from Rabbit)
- 60s ribosomal protein l27 (15 kDa, Protein from Rabbit)
- 60s ribosomal protein l10 (24 kDa, Protein from Rabbit)
- 40s ribosomal protein s27 (9 kDa, Protein from Rabbit)
- 60s ribosomal protein l6 (33 kDa, Protein from Rabbit)
- El40 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein l8 (28 kDa, Protein from Rabbit)
- Ul10 (34 kDa, Protein from Oryctolagus cuniculus)
- Ul13 (23 kDa, Protein from Oryctolagus cuniculus)
- 5.8s ribosomal rna (50 kDa, RNA from Oryctolagus cuniculus)
- Trna (lys3) (24 kDa, RNA from Oryctolagus cuniculus)
- Ribosomal protein s5 (22 kDa, Protein from Rabbit)
- El29 (26 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s6 (28 kDa, Protein from Rabbit)
- El8 (36 kDa, Protein from Oryctolagus cuniculus)
- Ul22 (21 kDa, Protein from Rabbit)
- 40s ribosomal protein s12 (14 kDa, Protein from Rabbit)
- Wd_repeats_region domain-containing protein (35 kDa, Protein from Rabbit)
- El34 (13 kDa, Protein from Rabbit)
- Ul6 (21 kDa, Protein from Rabbit)
- Ul3 (46 kDa, Protein from Rabbit)
- Spermidine (145 Da, Ligand)
- 5s ribosomal rna (38 kDa, RNA from Oryctolagus cuniculus)
- Rabbit 80s ribosome stalled on polya mrna (4 MDa, Complex)
- 40s ribosomal protein s4 (29 kDa, Protein from Rabbit)
- Ribosomal protein s11 (18 kDa, Protein from Rabbit)
- Es17 (15 kDa, Protein from Rabbit)
- Ribosomal protein s28 (7 kDa, Protein from Rabbit)
- Ribosomal_s13_n domain-containing protein (17 kDa, Protein from Rabbit)
- Ribosomal protein l11 (20 kDa, Protein from Rabbit)
- Poly-lysine nascent chain (2 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Rabbit)
- Ribosomal protein s27a (18 kDa, Protein from Rabbit)
- Ul29 (14 kDa, Protein from Rabbit)
- El38 (8 kDa, Protein from Rabbit)
- Polya mrna (Complex from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Rabbit)
- Ribosomal protein s9 (predicted) (22 kDa, Protein from Rabbit)
- El32 (15 kDa, Protein from Rabbit)
- 60s ribosomal protein l5 (34 kDa, Protein from Rabbit)
- 40s ribosomal protein s30 (14 kDa, Protein from Rabbit)
- Ribosomal protein l15 (24 kDa, Protein from Rabbit)
- El21 (18 kDa, Protein from Rabbit)
- Ribosomal protein l14 (23 kDa, Protein from Rabbit)
- El18 (21 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal_s10 domain-containing protein (13 kDa, Protein from Rabbit)
Structure-function insights reveal the human ribosome as a cancer target for antibiotics
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5lks
Q-score: 0.429
Myasnikov AG, Kundhavai Natchiar S, Nebout M, Hazemann I, Imbert V, Khatter H, Peyron JF, Klaholz BP
Nat Commun (2016) 7 pp. 12856-12856 [ DOI: doi:10.1038/ncomms12856 Pubmed: 27665925 ]
- 40s ribosomal protein s29 (6 kDa, Protein from Human)
- 60s ribosomal protein l32 (15 kDa, Protein from Human)
- 60s ribosomal protein l13a (23 kDa, Protein from Human)
- 60s ribosomal protein l36 (12 kDa, Protein from Human)
- 40s ribosomal protein s15 (17 kDa, Protein from Human)
- 60s ribosomal protein l34 (13 kDa, Protein from Human)
- 60s ribosomal protein l36a (12 kDa, Protein from Human)
- 40s ribosomal protein s8 (24 kDa, Protein from Human)
- 5s ribosomal rna (38 kDa, RNA from Human)
- 60s ribosomal protein l6 (32 kDa, Protein from Human)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Human)
- 40s ribosomal protein s24 (15 kDa, Protein from Human)
- 60s ribosomal protein l23a (17 kDa, Protein from Human)
- 60s ribosomal protein l17 (21 kDa, Protein from Human)
- 40s ribosomal protein s12 (14 kDa, Protein from Human)
- 5.8s ribosomal rna (50 kDa, RNA from Human)
- 60s ribosomal protein l37 (11 kDa, Protein from Human)
- 60s ribosomal protein l39 (6 kDa, Protein from Human)
- 40s ribosomal protein s11 (18 kDa, Protein from Human)
- 40s ribosomal protein s16 (16 kDa, Protein from Human)
- 60s ribosomal protein l24 (17 kDa, Protein from Human)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Human)
- 60s ribosomal protein l9 (21 kDa, Protein from Human)
- 60s ribosomal protein l11 (20 kDa, Protein from Human)
- 40s ribosomal protein s3 (26 kDa, Protein from Human)
- 40s ribosomal protein s9 (22 kDa, Protein from Human)
- 40s ribosomal protein s20 (13 kDa, Protein from Human)
- 60s ribosomal protein l18a (20 kDa, Protein from Human)
- 60s ribosomal protein l35a (12 kDa, Protein from Human)
- 40s ribosomal protein s13 (17 kDa, Protein from Human)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l3 (46 kDa, Protein from Human)
- 60s ribosomal protein l23 (14 kDa, Protein from Human)
- Ribosomal protein s30 (14 kDa, Protein from Human)
- 60s ribosomal protein l38 (8 kDa, Protein from Human)
- 60s ribosomal protein l22 (14 kDa, Protein from Human)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Human)
- 60s ribosomal protein l8 (28 kDa, Protein from Human)
- 40s ribosomal protein s19 (16 kDa, Protein from Human)
- 60s ribosomal protein l41 (3 kDa, Protein from Human)
- 60s ribosomal protein l18 (21 kDa, Protein from Human)
- 40s ribosomal protein s6 (28 kDa, Protein from Human)
- 40s ribosomal protein sa (32 kDa, Protein from Human)
- 60s ribosomal protein l30 (12 kDa, Protein from Human)
- 60s ribosomal protein l27a (16 kDa, Protein from Human)
- 4-{(2r)-2-[(1s,3s,5s)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione (281 Da, Ligand)
- 40s ribosomal protein s23 (15 kDa, Protein from Human)
- 60s ribosomal protein l15 (24 kDa, Protein from Human)
- Water (18 Da, Ligand)
- 40s ribosomal protein s17 (15 kDa, Protein from Human)
- 40s ribosomal protein s15a (14 kDa, Protein from Human)
- 40s ribosomal protein s27 (9 kDa, Protein from Human)
- Ribosomal protein l29, isoform cra_a (17 kDa, Protein from Human)
- 60s ribosomal protein l19 (23 kDa, Protein from Human)
- 60s ribosomal protein l14 (23 kDa, Protein from Human)
- 60s ribosomal protein l7 (29 kDa, Protein from Human)
- 60s ribosomal protein l4 (47 kDa, Protein from Human)
- 60s ribosomal protein l35 (14 kDa, Protein from Human)
- 60s ribosomal protein l28 (15 kDa, Protein from Human)
- 60s ribosomal protein l5 (34 kDa, Protein from Human)
- 40s ribosomal protein s2 (31 kDa, Protein from Human)
- 40s ribosomal protein s5 (22 kDa, Protein from Human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Human)
- 60s ribosomal protein l10a (24 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- 40s ribosomal protein s10 (18 kDa, Protein from Human)
- 60s ribosomal protein l37a (10 kDa, Protein from Human)
- 40s ribosomal protein s25 (13 kDa, Protein from Human)
- 40s ribosomal protein s3a (30 kDa, Protein from Human)
- 40s ribosomal protein s7 (22 kDa, Protein from Human)
- 18s ribosomal rna (602 kDa, RNA from Human)
- 60s ribosomal protein l21 (18 kDa, Protein from Human)
- 60s ribosomal protein l10-like (24 kDa, Protein from Human)
- 60s ribosomal protein l13 (24 kDa, Protein from Human)
- 60s ribosomal protein l31 (14 kDa, Protein from Human)
- 40s ribosomal protein s28 (7 kDa, Protein from Human)
- 60s ribosomal protein l7a (30 kDa, Protein from Human)
- 40s ribosomal protein s14 (16 kDa, Protein from Human)
- Human 80s ribsome (Complex from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Human)
- 60s ribosomal protein l27 (15 kDa, Protein from Human)
- 40s ribosomal protein s21 (9 kDa, Protein from Human)
- 60s ribosomal protein l26 (17 kDa, Protein from Human)
- 28s ribosomal rna (1 MDa, RNA from Human)
- 40s ribosomal protein s26 (13 kDa, Protein from Human)
Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5mc6
Q-score: 0.362
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillere Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R
Science (2016) 354 pp. 1431-1433 [ DOI: doi:10.1126/science.aaf7520 Pubmed: 27980209 ]
- 60s ribosomal protein l31-a (12 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s3 (26 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l25 (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l13-a (22 kDa, Protein from Baker's yeast)
- 25s ribosomal rna (1 MDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 60s ribosomal protein l35-a (13 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l11-a (19 kDa, Protein from Baker's yeast)
- Ubiquitin-40s ribosomal protein s31 (17 kDa, Protein from Baker's yeast)
- Eukaryotic translation initiation factor 5a-1 (17 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s13 (17 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s24-a (15 kDa, Protein from Baker's yeast)
- Ul1 (17 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l10 (25 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s1-a (28 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l43-a (10 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l16-a (22 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s10-a (12 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s30-a (7 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l7-a (27 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l42-a (12 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s20 (13 kDa, Protein from Baker's yeast)
- Native ribosome-ski2-ski3-ski8 complex from s. cerevisiae (3 MDa, Complex from Saccharomyces cerevisiae)
- 40s ribosomal protein s21-a (9 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l15-a (24 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s2 (27 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s7-a (21 kDa, Protein from Baker's yeast)
- Antiviral helicase ski2 (146 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s4-a (29 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l4-a (39 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l28 (16 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l36-a (11 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l39 (6 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l23-a (14 kDa, Protein from Baker's yeast)
- 18s ribosomal rna (579 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 60s ribosomal protein l41-a (3 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l38 (8 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s8-a (22 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s26-a (13 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s11-a (17 kDa, Protein from Baker's yeast)
- 5s ribosomal rna (38 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 60s ribosomal protein l32 (14 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l26-a (14 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s12 (15 kDa, Protein from Baker's yeast)
- Superkiller protein 3 (163 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l17-a (20 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l5 (33 kDa, Protein from Baker's yeast)
- A-site trna (24 kDa, RNA from Baker's yeast)
- P-site trna (24 kDa, RNA from Baker's yeast)
- 40s ribosomal protein s15 (16 kDa, Protein from Baker's yeast)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l18-a (20 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s17-b (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l6-a (20 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l3 (43 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l19-a (21 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l34-a (13 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s28-b (7 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s27-a (8 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s29-a (6 kDa, Protein from Baker's yeast)
- Guanine nucleotide-binding protein subunit beta-like protein (34 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s23-a (16 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l20-a (20 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l30 (11 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s5 (25 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s6-a (27 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s22-a (14 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s19-a (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l27-a (15 kDa, Protein from Baker's yeast)
- Mrna (10 kDa, RNA from Baker's yeast)
- 40s ribosomal protein s25-a (12 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s16-a (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l2-a (27 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l14-a (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l37-a (9 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l22-a (13 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l24-a (17 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l29 (6 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s14-a (14 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s0-a (28 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l8-a (28 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l33-a (12 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l9-a (21 kDa, Protein from Baker's yeast)
- 5.8s ribosomal rna (50 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 40s ribosomal protein s18-a (17 kDa, Protein from Baker's yeast)
- Antiviral protein ski8 (44 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s9-a (22 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l21-a (18 kDa, Protein from Baker's yeast)