Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7lwd
Q-score: 0.466
Plenge P, Yang D, Salomon K, Laursen L, Kalenderoglou IE, Newman AH, Gouaux E, Coleman JA, Loland CJ
Nat Commun (2021) 12 pp. 5063-5063 [ Pubmed: 34417466 DOI: doi:10.1038/s41467-021-25363-3 ]
- Heavy chain antibody fragment (12 kDa, Protein from Mus musculus)
- 8b6 antibody (Complex from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- Light chain antibody fragment (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide (441 Da, Ligand)
- Serotonin transporter 8b6 fab complex (105 kDa, Complex)
- 3-(5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine (280 Da, Ligand)
- Sodium-dependent serotonin transporter (61 kDa, Protein from Homo sapiens)
Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6vrh
Q-score: 0.454
Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E
eLife (2020) 9 [ Pubmed: 32618269 DOI: doi:10.7554/eLife.56427 ]
- 8b6 antibody (Complex from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- 8b6 antibody, heavy chain (23 kDa, Protein from Mus musculus)
- Serotonin transporter 8b6 fab complex (105 kDa, Complex)
- Paroxetine (329 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 8b6 antibody, light chain (23 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (70 kDa, Protein from Homo sapiens)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6vrk
Q-score: 0.336
Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E
eLife (2020) 9 [ Pubmed: 32618269 DOI: doi:10.7554/eLife.56427 ]
- 8b6 antibody (Complex from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- 8b6 antibody, heavy chain (23 kDa, Protein from Mus musculus)
- Serotonin transporter 8b6 fab complex (105 kDa, Complex)
- Br-paroxetine (390 Da, Ligand)
- 8b6 antibody, light chain (23 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (70 kDa, Protein from Homo sapiens)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6vrl
Q-score: 0.365
Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E
eLife (2020) 9 [ Pubmed: 32618269 DOI: doi:10.7554/eLife.56427 ]
- 8b6 antibody (Complex from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- 8b6 antibody, heavy chain (23 kDa, Protein from Mus musculus)
- Serotonin transporter 8b6 fab complex (105 kDa, Complex)
- 8b6 antibody, light chain (23 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (70 kDa, Protein from Homo sapiens)
- I-paroxetine (437 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6dzw
Q-score: 0.174
Coleman JA, Yang D, Zhao Z, Wen PC, Yoshioka C, Tajkhorshid E, Gouaux E
Nature (2019) 569 pp. 141-145 [ DOI: doi:10.1038/s41586-019-1135-1 Pubmed: 31019304 ]
- Human serotonin transporter in complex with fab/fv bound to paroxetine (Complex)
- 15b8 antibody heavy chain (12 kDa, Protein from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- 15b8 fab (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Paroxetine (329 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- 8b6 antibody single chain (26 kDa, Protein from Mus musculus)
- 15b8 antibody light chain (11 kDa, Protein from Mus musculus)
- 8b6 scfv (Complex from Mus musculus)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6dzy
Q-score: 0.256
Coleman JA, Yang D, Zhao Z, Wen PC, Yoshioka C, Tajkhorshid E, Gouaux E
Nature (2019) 569 pp. 141-145 [ DOI: doi:10.1038/s41586-019-1135-1 Pubmed: 31019304 ]
- 15b8 antibody heavy chain (12 kDa, Protein from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- 15b8 fab (Complex from Mus musculus)
- Human serotonin transporter in complex with fab/fv bound to ibogaine (Complex)
- (5beta)-12-methoxyibogamine (310 Da, Ligand)
- 8b6 antibody single chain (26 kDa, Protein from Mus musculus)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 15b8 antibody light chain (11 kDa, Protein from Mus musculus)
- 8b6 scfv (Complex from Mus musculus)