Catalytic domain of human DNA polymerase alpha in complex with DNA and RPA
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9mj5
Q-score: 0.436
Baranovskiy AG, Morstadt LM, Romero EE, Babayeva ND, Tahirov TH
To Be Published
- Dna template (35-mer) (10 kDa, DNA from Homo sapiens)
- Replication protein a 14 kda subunit (13 kDa, Protein from Homo sapiens)
- Ternary complex of dna polymerase alpha with dna and replication protein a (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Replication protein a 70 kda dna-binding subunit (21 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Dna polymerase alpha catalytic subunit (103 kDa, Protein from Homo sapiens)
- Replication protein a 32 kda subunit (25 kDa, Protein from Homo sapiens)
- Rna-dna primer (11-mer) (3 kDa, Macromolecule from Homo sapiens)
Kappa opioid receptor:Galphai protein in complex with inverse agonist norBNI
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vve
Q-score: 0.333
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ DOI: doi:10.1038/s41589-024-01812-0 Pubmed: 39775170 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist norbni (130 kDa, Complex from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (4bs,8r,8as,10as,11r,14as,19ar,20br)-7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,20,20b-dodecahydro-19ah-4,8:11,15-dimethanobis[1]benzofuro[2,3-a:3',2'-i]dipyrido[4,3-b:3',4'-h]carbazole-1,8a,10a,18-tetrol (661 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of Cas9-sgRNA-A32 complex
Zheng J, Zhu Y, Huang T, Gao W, He J, Huang Z
Sci China Life Sci (2024) 67 pp. 1781-1791 [ Pubmed: 38842649 DOI: doi:10.1007/s11427-024-2607-8 ]
- Cas9-sgrna-a32 complex (Complex from Streptococcus pyogenes)
- A32 (16 kDa, Protein from Streptococcus)
- Rna (92-mer) (29 kDa, RNA from Streptococcus pyogenes)
- Crispr-associated endonuclease cas9/csn1 (158 kDa, Protein from Streptococcus pyogenes serotype M1)
Human Replication protein A (RPA; trimeric core) - ssDNA complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8rk2
Q-score: 0.436
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC
Nature (2024) 629 pp. 697-703 [ DOI: doi:10.1038/s41586-024-07347-7 Pubmed: 38658755 ]
- Replication protein a 32 kda subunit (29 kDa, Protein from Homo sapiens)
- Replication protein a 70 kda dna-binding subunit, n-terminally processed (68 kDa, Protein from Homo sapiens)
- Replication protein a 14 kda subunit (13 kDa, Protein from Homo sapiens)
- Open ring conformation of human rad52 in complex with ssdna (Complex from Homo sapiens)
Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prevost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB
Cell Host Microbe (2019) 25 pp. 578-587.e5 [ DOI: doi:10.1016/j.chom.2019.03.002 Pubmed: 30974085 ]
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5xlo
Q-score: 0.337
Peng R, Xu Y, Zhu T, Li N, Qi J, Chai Y, Wu M, Zhang X, Shi Y, Wang P, Wang J, Gao N, Gao GF
Cell Res (2017) 27 pp. 853-864 [ Pubmed: 28574055 DOI: doi:10.1038/cr.2017.79 ]
- Crrna with 20nt spacer sequence (Complex)
- Acrf1 (Complex)
- Crrna with 32nt spacer sequence (19 kDa, RNA from Pseudomonas aeruginosa)
- Uncharacterized protein acrf1 (8 kDa, Protein from Pseudomonas phage JBD30)
- Crispr-associated protein csy3 (37 kDa, Protein from Pseudomonas aeruginosa (strain UCBPP-PA14))
- Crispr-associated protein csy3 (Complex)
- Anti-crispr proteins acrf1/2 bound to csy surveillance complex with a 32nt spacer crrna backbone region (400 kDa, Complex from Pseudomonas aeruginosa (strain UCBPP-PA14))
Cryo-EM map of the Timeless-Tipin-RPA Complex
Nucleic Acids Res (2014) 42 pp. 12912-12927 [ Pubmed: 25348395 DOI: doi:10.1093/nar/gku960 ]
- Replication protein a 14 (16 kDa, Protein from Mus musculus)
- Timeless-tipin-rpa complex (270 kDa, Sample)
- Replication protein a 32 (28 kDa, Protein from Mus musculus)
- Replication protein a 70 (52 kDa, Protein from Mus musculus)
- Timeless (130 kDa, Protein from Mus musculus)
- Timeless-interacting protein (31 kDa, Protein from Mus musculus)