Cryo-EM structure of human ABCB6 transporter in an inward-facing conformation
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9dbq
Q-score: 0.417
Baril SA, Wilson KA, Shaik MM, Fukuda Y, Umans RA, Barbieri A, Lynch J, Gose T, Myasnikov A, Oldham ML, Wang Y, Zhu J, Fang J, Zuo J, Kalathur RC, Ford RC, Coffin A, Taylor MR, O'Mara ML, Schuetz JD
Nat Commun (2024) 15 pp. 9885-9885 [ DOI: doi:10.1038/s41467-024-53663-x Pubmed: 39557842 ]
- Atp-binding cassette sub-family b member 6 (94 kDa, Protein from Homo sapiens)
- Abcb6 (189 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of the human ABCB6 in complex with Cd(II):GSH
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8yr3
Q-score: 0.392
Choi SH, Lee SS, Lee HY, Kim S, Kim JW, Jin MS
Commun Biol (2024) 7 pp. 672-672 [ Pubmed: 38822018 DOI: doi:10.1038/s42003-024-06377-1 ]
- Atp-binding cassette sub-family b member 6 (71 kDa, Protein from Homo sapiens)
- Cadmium ion (112 Da, Ligand)
- Homodimer complex of atp-binding cassette transporter b6 in complex with cd(ii):gsh (143 MDa, Complex from Homo sapiens)
- Glutathione (307 Da, Ligand)
Cryo-EM structure of the human ABCB6 in complex with Cd(II):Phytochelatin 2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8yr4
Q-score: 0.382
Choi SH, Lee SS, Lee HY, Kim S, Kim JW, Jin MS
Commun Biol (2024) 7 pp. 672-672 [ Pubmed: 38822018 DOI: doi:10.1038/s42003-024-06377-1 ]
- Atp-binding cassette sub-family b member 6 (71 kDa, Protein from Homo sapiens)
- Phytochelatin 2 (539 Da, Protein from Tracheophyta)
- Homodimer of atp-binding cassette transporter b6 in complex with cd(ii):phytochelatin 2 (143 MDa, Cellular component from Homo sapiens)
- Cadmium ion (112 Da, Ligand)
post-occluded structure of human ABCB6 W546A mutant (ADP/VO4-bound)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8k7b
Q-score: 0.497
Lee SS, Park JG, Jang E, Choi SH, Kim S, Kim JW, Jin MS
Commun Biol (2023) 6 pp. 960-960 [ Pubmed: 37735522 DOI: doi:10.1038/s42003-023-05339-3 ]
- Atp-binding cassette sub-family b member 6 (66 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Atp-binding cassette sub-family b member 6 - homo sapiens (Cellular component from Homo sapiens)
- Adp orthovanadate (544 Da, Ligand)
- (1s)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (720 Da, Ligand)
Outward-facing structure of human ABCB6 W546A mutant (ADP/VO4-bound)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8k7c
Q-score: 0.451
Lee SS, Park JG, Jang E, Choi SH, Kim S, Kim JW, Jin MS
Commun Biol (2023) 6 pp. 960-960 [ Pubmed: 37735522 DOI: doi:10.1038/s42003-023-05339-3 ]
- Atp-binding cassette sub-family b member 6 (65 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family b member 6 - homo sapiens (Cellular component from Homo sapiens)
- Vanadate ion (114 Da, Ligand)
CryoEM structure of Human ABCB6 Transporter
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8fwk
Q-score: 0.33
To Be Published
- Atp-binding cassette sub-family b member 6 (94 kDa, Protein from Homo sapiens)
- Two chains make the complex (170 kDa, Complex from Homo sapiens)
Cryo-EM structure of the human ABCB6 (coproporphyrin III-bound)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7dny
Q-score: 0.344
Kim S, Lee SS, Park JG, Kim JW, Ju S, Choi SH, Kim S, Kim NJ, Hong S, Kang JY, Jin MS
Mol Cells (2022) 45 pp. 575-587 [ Pubmed: 35950458 DOI: doi:10.14348/molcells.2022.0040 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Abcb6 (Complex from Homo sapiens)
- Coproporphyrin iii (654 Da, Ligand)
- Atp-binding cassette sub-family b member 6, mitochondrial (93 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human ABCB6 (Hemin and GSH-bound)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7dnz
Q-score: 0.415
Kim S, Lee SS, Park JG, Kim JW, Ju S, Choi SH, Kim S, Kim NJ, Hong S, Kang JY, Jin MS
Mol Cells (2022) 45 pp. 575-587 [ Pubmed: 35950458 DOI: doi:10.14348/molcells.2022.0040 ]
- Glutathione (307 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Abcb6 (Complex from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Atp-binding cassette sub-family b member 6, mitochondrial (93 kDa, Protein from Homo sapiens)
Mitochondrial outer membrane protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ekl
Q-score: 0.5
Song G, Zhang S, Tian M, Zhang L, Guo R, Zhuo W, Yang M
Cell Discov (2021) 7 pp. 55-55 [ Pubmed: 34312373 DOI: doi:10.1038/s41421-021-00284-z ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family b member 6 (93 kDa, Protein from Homo sapiens)
- Mitochondrial outer membrane protein (Cellular component from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
