The structure of human ABCG5-WT/ABCG8-I419E
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7r87
Q-score: 0.506
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2110483118 Pubmed: 34404721 ]
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- Abcg5/abcg8 transporter (Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Abcg1 transporter with fab 2c7 (150 kDa, Complex)
- 2c7 fab (Complex from Mus musculus)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
The structure of human ABCG5-I529W/ABCG8-WT
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7r88
Q-score: 0.493
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2110483118 Pubmed: 34404721 ]
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- Abcg5-i529w/abcg8 transporter (Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Fab 2c7 (Complex from Mus musculus)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Abcg5-i529w/abcg8 transporter with fab 2c7 bound (150 kDa, Complex)
The structure of human ABCG5/ABCG8 purified from yeast
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7r89
Q-score: 0.595
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2110483118 Pubmed: 34404721 ]
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- Ergosterol (396 Da, Ligand)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- Fab 2c7 (Complex from Mus musculus)
- Abcg1 transporter (Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Abcg1 transporter with ergosterol and fab 2c7 bound (150 kDa, Complex)
The structure of human ABCG5/ABCG8 purified from mammalian cells
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7r8a
Q-score: 0.552
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2110483118 Pubmed: 34404721 ]
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- Abcg1 transporter with cholesterol and fab 2c7 bound (150 kDa, Complex)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- Fab 2c7 (Complex from Mus musculus)
- Abcg1 transporter (Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
The structure of human ABCG5/ABCG8 supplemented with cholesterol
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7r8b
Q-score: 0.533
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2110483118 Pubmed: 34404721 ]
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- Abcg1 transporter with cholesterol and fab 2c7 bound (150 kDa, Complex)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- Fab 2c7 (Complex from Mus musculus)
- Abcg1 transporter with cholesterol bound (Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7jr7
Q-score: 0.491
Zhang H, Huang CS, Yu X, Lee J, Vaish A, Chen Q, Zhou M, Wang Z, Min X
Commun Biol (2021) 4 pp. 526- [ DOI: doi:10.1038/s42003-021-02039-8 ]
- Fab 11f4 light chain (23 kDa, Protein from Homo sapiens)
- Atp-binding cassette sub-family g member 8 (75 kDa, Protein from Homo sapiens)
- Fab 2e10 heavy chain (24 kDa, Protein from Homo sapiens)
- Fab 11f4 (Complex from Homo sapiens)
- Fab 11f4 heavy chain (24 kDa, Protein from Homo sapiens)
- Abcg5/g8 in complex with fab 2e10 and 11f4 (Complex)
- Abcg5/g8 (Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 5 (72 kDa, Protein from Homo sapiens)
- Fab 2e10 light chain (23 kDa, Protein from Homo sapiens)
- Fab 2e10 (Complex from Homo sapiens)