Structure of the AVP-V2R-arrestin2-ScFv30 complex
Resolution: 4.73 Å
EM Method: Single-particle
Fitted PDBs: 7r0c
Q-score: 0.249
Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, Saint-Paul J, Lai-Kee-Him J, Urbach S, Sibille N, Sounier R, Granier S, Mouillac B, Bron P
Sci Adv (2022) 8 pp. eabo7761-eabo7761 [ Pubmed: 36054364 DOI: doi:10.1126/sciadv.abo7761 ]
- Scfv30 (30 kDa, Protein from synthetic construct)
- Arrestin2 (47 kDa, Protein from Homo sapiens)
- Ternary complex of the avp-v2 receptor with arrestin2 and scfv30 (Complex from Homo sapiens)
- Vasopressin v2 receptor (41 kDa, Protein from Homo sapiens)
- Avp (1 kDa, Protein from Homo sapiens)
AVP-V2R-Galphas-beta1-gamma2-Nb35 (L state)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7bb6
Q-score: 0.344
Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B
Sci Adv (2021) 7 [ DOI: doi:10.1126/sciadv.abg5628 Pubmed: 34020960 ]
- Avp-v2r-galphas-beta1-gamma2-nb35 (l state) (156 kDa, Complex)
- Nanobody 35 (Complex from Lama glama)
- Arginine-vasopressin (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- V2r and guanine nucleotide-binding protein g(i)/g(s)/g(t) (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Vasopressin v2 receptor (47 kDa, Protein from Homo sapiens)
- Arginine-vasopressin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
AVP-V2R-Galphas-beta1-gamma2-Nb35(T state)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7bb7
Q-score: 0.33
Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B
Sci Adv (2021) 7 [ DOI: doi:10.1126/sciadv.abg5628 Pubmed: 34020960 ]
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- V2r and guanine nucleotide-binding protein g(i)/g(s)/g(t) (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Vasopressin (Complex from Homo sapiens)
- Vasopressin (1 kDa, Protein from Homo sapiens)
- Vasopressin v2 receptor (47 kDa, Protein from Homo sapiens)
- Avp-v2r-galphas-beta1-gamma2-nb35(t state) (156 kDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7kh0
Q-score: 0.523
Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C
Cell Res (2021) 31 pp. 932-934 [ DOI: doi:10.1038/s41422-021-00483-z Pubmed: 33664408 ]
- Single fab chain (scfv16) (26 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Nanobody 35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, single fab chain (scfv16) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Arg-vasopressin (1 kDa, Protein from Homo sapiens)
- Vasopressin v2 receptor (42 kDa, Protein from Homo sapiens)
- Vasopressin v2 receptor complex with gs and avp (Complex)
- Vasopressin v2 receptor, arg-vasopressin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)