Cryo-EM structure of Cortactin-bound to Arp2/3 complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8tah
Q-score: 0.514
Fregoso FE, Boczkowska M, Rebowski G, Carman PJ, van Eeuwen T, Dominguez R
Nat Commun (2023) 14 pp. 6894-6894 [ Pubmed: 37898612 DOI: doi:10.1038/s41467-023-42229-y ]
- Magnesium ion (24 Da, Ligand)
- Actin-related protein 2/3 complex subunit 4 (19 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 2 (34 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 1a (41 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 5 (16 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 3 (20 kDa, Protein from Bos taurus)
- Src substrate cortactin (8 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin-related protein 2 (44 kDa, Protein from Bos taurus)
- Actin-related protein 3 (47 kDa, Protein from Bos taurus)
- Cortactin nta bound to arp2/3 complex (223 kDa, Complex from Bos taurus)
Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7t5q
Q-score: 0.385
van Eeuwen T, Boczkowska M, Rebowski G, Carman PJ, Fregoso FE, Dominguez R
PNAS (2023) 120 pp. e2306165120-e2306165120 [ Pubmed: 37549294 DOI: doi:10.1073/pnas.2306165120 ]
- Magnesium ion (24 Da, Ligand)
- Bovine arp2/3 (Complex from Bos taurus)
- Actin-related protein 2/3 complex subunit 4 (19 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 2 (34 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 5 (16 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 1a (41 kDa, Protein from Bos taurus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin-related protein 2/3 complex subunit 3 (20 kDa, Protein from Bos taurus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- F-actin-capping protein subunit beta/actin nucleation-promoting factor wasl chimera (37 kDa, Protein from Mus musculus)
- Actin skeletal muscle (Complex from Oryctolagus cuniculus)
- Actin-related protein 2 (44 kDa, Protein from Bos taurus)
- Actin, alpha skeletal muscle (41 kDa, Protein from Oryctolagus cuniculus)
- Actin-related protein 3 (47 kDa, Protein from Bos taurus)
- Bovine arp2/3 complex and actin, capz (248 kDa, Complex)
- F-actin-capping protein subunit alpha-1/actin nucleation-promoting factor wasl chimera (39 kDa, Protein from Mus musculus)
- F-actin-capping protein (Complex from Homo sapiens)
Cryo-EM structure of Arpin-bound Arp2/3 complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7jpn
Q-score: 0.433
Fregoso FE, van Eeuwen T, Simanov G, Rebowski G, Boczkowska M, Zimmet A, Gautreau AM, Dominguez R
Nat Commun (2022) 13 pp. 628-628 [ DOI: doi:10.1038/s41467-022-28112-2 Pubmed: 35110533 ]
- Actin-related protein 2/3 complex subunit 5 (15 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Bovine arp2/3 (Complex from Bos taurus)
- Bovine arp2/3 complex with arpin (248 kDa, Complex)
- Actin-related protein 2/3 complex subunit 2 (34 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 4 (19 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 3 (20 kDa, Protein from Bos taurus)
- Arpin (3 kDa, Protein from Homo sapiens)
- Actin-related protein 2/3 complex subunit 1b (41 kDa, Protein from Bos taurus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin-related protein 2 (42 kDa, Protein from Bos taurus)
- Actin-related protein 3 (46 kDa, Protein from Bos taurus)
- Arpin (Complex from Homo sapiens)
CryoEM structure of human Arp2/3 complex with bound NPFs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6uhc
Q-score: 0.353
Zimmet A, Van Eeuwen T, Boczkowska M, Rebowski G, Murakami K, Dominguez R
Sci Adv (2020) 6 pp. eaaz7651-eaaz7651 [ Pubmed: 32548263 DOI: doi:10.1126/sciadv.aaz7651 ]
- Magnesium ion (24 Da, Ligand)
- Actin-related protein 2/3 complex subunit 4 (19 kDa, Protein from Homo sapiens)
- Actin-related protein 3 (47 kDa, Protein from Homo sapiens)
- Actin-related protein 2/3 complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Cryo-em structure of human arp2/3 complex with bound npfs (243 MDa, Complex from Spodoptera aff. frugiperda 1 BOLD-2017)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin-related protein 2/3 complex subunit 3 (23 kDa, Protein from Homo sapiens)
- Actin-related protein 2/3 complex subunit 5 (16 kDa, Protein from Homo sapiens)
- Actin-related protein 2/3 complex subunit 1b (41 kDa, Protein from Homo sapiens)
- Neural wiskott-aldrich syndrome protein (54 kDa, Protein from Mus musculus)
- Actin-related protein 2 (44 kDa, Protein from Homo sapiens)