Structure of the human neutral amino acid transporter ASCT2 in complex with nanobody 469
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 8oud
Q-score: 0.666
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) 31 pp. 1368-1376 [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Complex of human asct2 with nanobody 69 (200 kDa, Complex)
- Alanine (89 Da, Ligand)
- Water (18 Da, Ligand)
- Neutral amino acid transporter b(0) (56 kDa, Protein from Homo sapiens)
- Alanine serine cysteine transporter 2 (Complex from Homo sapiens)
- Nanobody 469 (13 kDa, Protein from Lama glama)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Nanobody 69 (Complex from Lama glama)
- Sodium ion (22 Da, Ligand)
Complex of human ASCT2 with Syncytin-1
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8ouh
Q-score: 0.553
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) 31 pp. 1368-1376 [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Alanine serine cysteine transporter 2 (Complex from Homo sapiens)
- Syncytin-1 (Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (58 kDa, Protein from Homo sapiens)
- Syncytin-1 (49 kDa, Protein from Homo sapiens)
- Complex of asct2 with synctin-1 (180 MDa, Complex)
- Alanine (89 Da, Ligand)
Complex of ASCT2 with Suppressyn
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8oui
Q-score: 0.435
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) 31 pp. 1368-1376 [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Alanine (89 Da, Ligand)
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)
- Suppressyn (18 kDa, Protein from Homo sapiens)
- Complex of alanine serine cysteine transporter 2 with suppressyn (Complex from Homo sapiens)
Heterotrimeric Complex of Human ASCT2 with Syncytin-1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ouj
Q-score: 0.339
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) 31 pp. 1368-1376 [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Alanine serine cysteine transporter 2 (Complex from Homo sapiens)
- Syncytin-1 (Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (58 kDa, Protein from Homo sapiens)
- Syncytin-1 (49 kDa, Protein from Homo sapiens)
- Complex asct2 with syncytin-1 (180 MDa, Complex)
- Alanine (89 Da, Ligand)
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 6rvx
Q-score: 0.488
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)
Inward-open structure of the ASCT2 (SLC1A5) in absence of substrate
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- Asct2 (Protein from Homo sapiens)
- Asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate
Resolution: 4.13 Å
EM Method: Single-particle
Fitted PDBs: 6rvy
Q-score: 0.369
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)