cryo-EM reconstruction of microtubule-bound 2R-Tau
Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E
Science (2018) 360 pp. 1242-1246 [ Pubmed: 29748322 DOI: doi:10.1126/science.aat1780 ]
- 2r-tau (Protein from Homo sapiens)
- Beta-tubulin (Protein from Sus scrofa)
- Alpha-tubulin (Protein from Sus scrofa)
- Ternary complex of alpha-beta tubulin with shortened tau construct (Complex from Sus scrofa)
cryo-EM reconstruction of microtubule-bound full-length Tau
Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E
Science (2018) 360 pp. 1242-1246 [ Pubmed: 29748322 DOI: doi:10.1126/science.aat1780 ]
cryo-EM reconstruction of microtubule-bound 4R-tau
Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E
Science (2018) 360 pp. 1242-1246 [ Pubmed: 29748322 DOI: doi:10.1126/science.aat1780 ]
- Ternary complex of alpha-beta tubulin with shortened tau construct (Complex from Homo sapiens)
- Alpha-tubulin (Protein from Sus scrofa)
- Beta-tubulin (Protein from Sus scrofa)
- 4rtau (Protein from Homo sapiens)
Near-atomic resolution cryo-EM reconstruction of peloruside-stabilized microtubule
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5syc
Q-score: 0.426
Kellogg EH, Hejab NM, Howes S, Northcote P, Miller JH, Diaz JF, Downing KH, Nogales E
J Mol Biol (2017) 429 pp. 633-646 [ Pubmed: 28104363 DOI: doi:10.1016/j.jmb.2017.01.001 ]
- Magnesium ion (24 Da, Ligand)
- Tubulin alpha chain (48 kDa, Protein from Sus scrofa)
- Tubulin beta chain (47 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Peloruside a (548 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ternary complex of peloruside-stabilized microtubule lattice, alpha-tubulin, and beta-tubulin (Complex from Sus scrofa)
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5sye
Q-score: 0.372
Kellogg EH, Hejab NM, Howes S, Northcote P, Miller JH, Diaz JF, Downing KH, Nogales E
J Mol Biol (2017) 429 pp. 633-646 [ Pubmed: 28104363 DOI: doi:10.1016/j.jmb.2017.01.001 ]
- Tubulin alpha chain (48 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (47 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Peloruside a (548 Da, Ligand)
- Taxol (853 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ternary complex of taxol- and peloruside-stabilized microtubule lattice, alpha-tubulin, and beta-tubulin (Complex from Sus scrofa)
High-resolution cryo-EM reconstruction of Taxol-stabilized microtubule
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5syf
Q-score: 0.39
Kellogg EH, Hejab NM, Howes S, Northcote P, Miller JH, Diaz JF, Downing KH, Nogales E
J Mol Biol (2017) 429 pp. 633-646 [ Pubmed: 28104363 DOI: doi:10.1016/j.jmb.2017.01.001 ]
- Tubulin alpha chain (48 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (47 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Taxol (853 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ternary complex of taxol-stabilized microtubule lattice, alpha-tubulin, and beta-tubulin (Complex from Sus scrofa)
Cryo-EM reconstruction of zampanolide-bound microtubule
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5syg
Q-score: 0.303
Kellogg EH, Hejab NM, Howes S, Northcote P, Miller JH, Diaz JF, Downing KH, Nogales E
J Mol Biol (2017) 429 pp. 633-646 [ Pubmed: 28104363 DOI: doi:10.1016/j.jmb.2017.01.001 ]
- (2z,4e)-n-[(s)-[(1s,2e,5s,8e,10z,17s)-3,11-dimethyl-19-methylidene-7,13-dioxo-6,21-dioxabicyclo[15.3.1]henicosa-2,8,10-trien-5-yl](hydroxy)methyl]hexa-2,4-dienamide (497 Da, Ligand)
- Tubulin alpha chain (48 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (47 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ternary complex of zampanolide-stabilized microtubule lattice, alpha-tubulin, and beta-tubulin (Complex from Sus scrofa)
The beginning of kinesin's force-generating cycle visualized at 9-A resolution.
Resolution: 9.0 Å
EM Method: Single-particle
Fitted PDBs: 2p4n
Q-score: 0.079
J Cell Biol (2007) 177 pp. 377-385 [ DOI: doi:10.1083/jcb.200612090 Pubmed: 17470637 ]
- Beta-tubulin (49 kDa, Protein from Homo sapiens)
- Alpha-tubulin (50 kDa, Protein from Homo sapiens)
- Kinesin (36 kDa, Protein from Homo sapiens)
- Nucleotide-free kinesin bound to a 13-protofilament microtubule (Sample)