Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Cryo-EM map of calcium-bound mTMEM16A(ac)-L647V/I733V chloride channel at 3.29 A resolution
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8qzc
Q-score: 0.441
EMBO J (2023) 42 pp. e115030-e115030 [ DOI: doi:10.15252/embj.2023115030 Pubmed: 37984335 ]
Cryo-EM map of 1PBC- and calcium-bound mTMEM16A(ac) chloride channel at 2.85 A resolution
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7zk3
Q-score: 0.522
Nat Commun (2022) 13 pp. 2798-2798 [ Pubmed: 35589730 DOI: doi:10.1038/s41467-022-30479-1 ]
- 1-hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile (277 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Mouse tmem16a ac splice variant in complex with 1pbc and calcium (Cellular component from Mus musculus)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
Cryo-EM map of calcium-bound mTMEM16A(ac) chloride channel at 3.7 A resolution
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7b5c
Q-score: 0.422
Lam AKM, Rheinberger J, Paulino C, Dutzler R
Nat Commun (2021) 12 pp. 785-785 [ DOI: doi:10.1038/s41467-020-20787-9 Pubmed: 33542223 ]
- Mtmem16a(ac) in calcium-bound form (221 kDa, Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
Cryo-EM map of calcium-free mTMEM16A(ac)-I551A chloride channel at 3.3 A resolution
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7b5d
Q-score: 0.491
Lam AKM, Rheinberger J, Paulino C, Dutzler R
Nat Commun (2021) 12 pp. 785-785 [ DOI: doi:10.1038/s41467-020-20787-9 Pubmed: 33542223 ]
- Mtmem16a(ac)-i551a in calcium-free form (221 kDa, Complex from Mus musculus)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
Cryo-EM map of calcium-bound mTMEM16A(ac)-I551A chloride channel at 4.1 A resolution
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7b5e
Q-score: 0.389
Lam AKM, Rheinberger J, Paulino C, Dutzler R
Nat Commun (2021) 12 pp. 785-785 [ DOI: doi:10.1038/s41467-020-20787-9 Pubmed: 33542223 ]
- Mtmem16a(ac)-i551a in calcium-bound form (221 kDa, Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6bgi
Q-score: 0.293
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbuhler K, Ye W, Qi L, Chen T, Craik CS, Nung Jan Y, Minor DL, Cheng Y, Yeh Jan L
Nature (2017) 552 pp. 426-429 [ Pubmed: 29236684 DOI: doi:10.1038/nature25024 ]
- Anoctamin-1 (105 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Tmem16a in nanodsic (Cell from Mus musculus)
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6bgj
Q-score: 0.296
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbuhler K, Ye W, Qi L, Chen T, Craik CS, Nung Jan Y, Minor DL, Cheng Y, Yeh Jan L
Nature (2017) 552 pp. 426-429 [ Pubmed: 29236684 DOI: doi:10.1038/nature25024 ]
- Anoctamin-1 (105 kDa, Protein from Mus musculus)
- Tmem16a calcium-activated chloride channel (Cell from Mus musculus)
- Calcium ion (40 Da, Ligand)
Cryo-EM map of calcium-bound mTMEM16A chloride channel at 3.75 A resolution
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 5oyb
Q-score: 0.418
Paulino C, Kalienkova V, Lam AKM, Neldner Y, Dutzler R
Nature (2017) 552 pp. 421-425 [ Pubmed: 29236691 DOI: doi:10.1038/nature24652 ]
- Mtmem16a with calcium ions bound (110 kDa, Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
Cryo-EM map of calcium-free mTMEM16A chloride channel at 4.06 A resolution
Resolution: 4.06 Å
EM Method: Single-particle
Fitted PDBs: 5oyg
Q-score: 0.362
Paulino C, Kalienkova V, Lam AKM, Neldner Y, Dutzler R
Nature (2017) 552 pp. 421-425 [ Pubmed: 29236691 DOI: doi:10.1038/nature24652 ]
- Mtmem16a in absence of calcium ions (110 kDa, Complex from Mus musculus)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)