Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Tamsulosin (408 Da, Ligand)
- Hexane (86 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
Cryo-EM map of 1PBC- and calcium-bound mTMEM16A(ac) chloride channel at 2.85 A resolution
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7zk3
Q-score: 0.522
Nat Commun (2022) 13 pp. 2798-2798 [ Pubmed: 35589730 DOI: doi:10.1038/s41467-022-30479-1 ]
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Mouse tmem16a ac splice variant in complex with 1pbc and calcium (Cellular component from Mus musculus)
- 1-hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile (277 Da, Ligand)
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6bgi
Q-score: 0.293
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbuhler K, Ye W, Qi L, Chen T, Craik CS, Nung Jan Y, Minor DL, Cheng Y, Yeh Jan L
Nature (2017) 552 pp. 426-429 [ Pubmed: 29236684 DOI: doi:10.1038/nature25024 ]
- Tmem16a in nanodsic (Cell from Mus musculus)
- Anoctamin-1 (105 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6bgj
Q-score: 0.296
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbuhler K, Ye W, Qi L, Chen T, Craik CS, Nung Jan Y, Minor DL, Cheng Y, Yeh Jan L
Nature (2017) 552 pp. 426-429 [ Pubmed: 29236684 DOI: doi:10.1038/nature25024 ]
- Tmem16a calcium-activated chloride channel (Cell from Mus musculus)
- Anoctamin-1 (105 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution.
Resolution: 6.6 Å
EM Method: Single-particle
Fitted PDBs: 5nl2
Q-score: 0.292
Paulino C, Neldner Y, Lam AK, Kalienkova V, Brunner JD, Schenck S, Dutzler R
eLife (2017) 6 [ DOI: doi:10.7554/eLife.26232 Pubmed: 28561733 ]
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Mtmem16a (110 kDa, Complex from Mus musculus)