Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9jqt
Q-score: 0.555
Yin H, Li L, Feng X, Wang Z, Zheng M, Zhao J, Fan X, Wu W, Gao L, Zhan Y, Zhao M, Lu Q
Signal Transduct Target Ther (2024) 9 pp. 323-323 [ Pubmed: 39551768 DOI: doi:10.1038/s41392-024-02017-6 ]
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- 2d4-heavy chain (23 kDa, Protein from Homo sapiens)
- Cytokine receptor common subunit gamma (28 kDa, Protein from Homo sapiens)
- 2d4-light chain (23 kDa, Protein from Homo sapiens)
- Interleukin receptor common gamma chain (il2rgamma/cd132) in complex with 2d4 (Complex from Homo sapiens)
Cryo-EM structure of ETAR bound with Macitentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Macitentan (588 Da, Ligand)
- Complex of endothelin receptor type a with macitentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
Cryo-EM structure of ETAR bound with Ambrisentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Complex of endothelin receptor type a with ambrisentan (Complex from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Ambrisentan (378 Da, Ligand)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
Cryo-EM structure of ETAR bound with Zibotentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Complex of endothelin receptor type a with zibotentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Zibotentan (424 Da, Ligand)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 9cmi
Q-score: 0.468
Rathnayake SS, Erramilli SK, Kossiakoff AA, Vecchio AJ
Structure (2024) 32 pp. 1936- [ DOI: doi:10.1016/j.str.2024.09.015 Pubmed: 39383874 ]
- Water (18 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Anti-fab nanobody (13 kDa, Protein from Homo sapiens)
- Heat-labile enterotoxin b chain (33 kDa, Protein from Clostridium perfringens)
- Claudin-4 (22 kDa, Protein from Homo sapiens)
- Human claudin-4 complex with clostridium perfringens enterotoxin, sfab cop-1, and nanobody (120 kDa, Complex from synthetic construct)
- Cop-1 sfab heavy chain (28 kDa, Protein from Homo sapiens)
- Cop-1 sfab light chain (25 kDa, Protein from Homo sapiens)
Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8th3
Q-score: 0.532
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
ZIKV rsNS1 in complex with Fab AA12 and anti-fab nanobody
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wnp
Q-score: 0.428
Chew BLA, Ngoh AQ, Phoo WW, Weng MJG, Sheng HJ, Chan KWK, Tan EYJ, Gelbart T, Xu C, Tan GS, Vasudevan SG, Luo D
Npj Viruses (2024) 2 pp. 14- [ DOI: doi:10.1038/s44298-024-00024-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Zikv rsns1 in complex with fab aa12 and anti-fab nanobody (Complex from Zika virus)
- Vh chains (23 kDa, Protein from Homo sapiens)
- Vl chains (23 kDa, Protein from Homo sapiens)
ZIKV rsNS1 in complex with Fab GB5 and anti-fab nanobody
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8wnu
Q-score: 0.331
Chew BLA, Ngoh AQ, Phoo WW, Weng MJG, Sheng HJ, Chan KWK, Tan EYJ, Gelbart T, Xu C, Tan GS, Vasudevan SG, Luo D
Npj Viruses (2024) 2 pp. 14- [ DOI: doi:10.1038/s44298-024-00024-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- Vh (23 kDa, Protein from Homo sapiens)
- Zikv rsns1 in complex with fab gb5 and anti-fab nanobody (Complex from Zika virus)
- Vl (23 kDa, Protein from Homo sapiens)
ZIKV rsNS1 in complex with Fab EB9 and anti-fab nanobody
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8wo4
Q-score: 0.416
Chew BLA, Ngoh AQ, Phoo WW, Weng MJG, Sheng HJ, Chan KWK, Tan EYJ, Gelbart T, Xu C, Tan GS, Vasudevan SG, Luo D
Npj Viruses (2024) 2 pp. 14- [ DOI: doi:10.1038/s44298-024-00024-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vl (23 kDa, Protein from Homo sapiens)
- Vh (24 kDa, Protein from Homo sapiens)
- Zikv rsns1 in complex with fab aa12 and anti-fab nanobody (Complex from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from Lama glama)
- Non-structural protein 1 (41 kDa, Protein from Zika virus)