cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and VacW-209
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N
Protein Cell (2024) 15 pp. 121-134 [ DOI: doi:10.1093/procel/pwad040 Pubmed: 37470320 ]
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 7wp0
Q-score: 0.48
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Ig c335_light_iglv1-40_iglj3 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 delta s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Vacw-209 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 delta (Complex)
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 7wp2
Q-score: 0.498
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 c.1.2 s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7won
Q-score: 0.464
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Neutralizing antibody vacw-209 (Complex)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s2p (Complex from Homo sapiens)
- Sars-cov-2 s2p trimer in complex with neutralizing antibody vacw-209 (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 7wp1
Q-score: 0.463
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Antibody vacw-209 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 mu s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
- Sars-cov-2 mu (Complex)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wp5
Q-score: 0.445
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
- Spikeprotein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
