Composite structure of Dynein-Dynactin-JIP3-LIS1
Resolution: 10.0 Å
EM Method: Single-particle
Fitted PDBs: 8ptk
Q-score: 0.202
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Dynactin subunits (Complex from Sus scrofa)
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
- C-jun-amino-terminal kinase-interacting protein 3 (65 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Dynactin subunit 2 (44 kDa, Protein from Sus scrofa)
- Dynactin 6 (20 kDa, Protein from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dynein light chain tctex-type 1 (12 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Dynactin subunit 3 (21 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Actin, cytoplasmic 1 (41 kDa, Protein from Sus scrofa)
- Arp11 (46 kDa, Protein from Sus scrofa)
- Dynactin subunit 4 (52 kDa, Protein from Sus scrofa)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Composite structure of dynein-dynactin-jip3-lis1 (Complex)
- Magnesium ion (24 Da, Ligand)
- Dynactin subunit 5 (20 kDa, Protein from Sus scrofa)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Dynein and jip3 (Complex from Homo sapiens)
- F-actin-capping protein subunit beta (30 kDa, Protein from Sus scrofa)
The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7z8i
Q-score: 0.466
Nature (2022) 610 pp. 212-216 [ Pubmed: 36071160 DOI: doi:10.1038/s41586-022-05186-y ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- F-actin capping protein beta subunit (30 kDa, Protein from Sus scrofa)
- Dynactin (Cellular component from Sus scrofa)
- Dynein, cytoplasmic 1 (Cellular component from Homo sapiens)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Complex of dynein, dynactin, and bicdr1 bound to microtubules (130 kDa, Complex)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Bicd family-like cargo adapter 1 (65 kDa, Protein from Mus musculus)
- Cytoplasmic dynein 1 intermediate chain 2 (71 kDa, Protein from Homo sapiens)
- Bicdr1 (Cellular component from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
Composite structure of dynein-dynactin-BICDR on microtubules
Resolution: 20.0 Å
EM Method: Single-particle
Fitted PDBs: 7z8f
Q-score: 0.215
Nature (2022) 610 pp. 212-216 [ Pubmed: 36071160 DOI: doi:10.1038/s41586-022-05186-y ]
- Bicdr1 (130 kDa, Cellular component from Mus musculus)
- Complex of dynein, dynactin, and bicdr1 bound to microtubules (4 MDa, Complex)
- Bicd family-like cargo adapter 1 (65 kDa, Protein from Mus musculus)
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
- Dynactin (1 MDa, Cellular component from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- F-actin capping protein beta subunit (30 kDa, Protein from Sus scrofa)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (44 kDa, Protein from Sus scrofa)
- Dynactin 6 (20 kDa, Protein from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Dynactin subunit 3 (21 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Actin, cytoplasmic 1 (41 kDa, Protein from Sus scrofa)
- Arp11 (46 kDa, Protein from Sus scrofa)
- Dynactin subunit 4 (52 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 intermediate chain 2 (71 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dynactin subunit 5 (20 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Dynein, cytoplasmic 1 (1 MDa, Cellular component from Homo sapiens)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)