Cryo-EM structure of human N-terminally bound ATG9A-ATG2A-WIPI4 complex
Wang Y, Dahmane S, Ti R, Mai X, Zhu L, Carlson LA, Stjepanovic G
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01376-6 Pubmed: 39174844 ]
- Wd repeat domain phosphoinositide-interacting protein 4 (39 kDa, Protein from Homo sapiens)
- Autophagy-related protein 2 homolog a (213 kDa, Protein from Homo sapiens)
- Autophagy-related protein 9a (94 kDa, Protein from Homo sapiens)
- N-terminally bound atg9a-atg2a-wipi4 complex (536 kDa, Complex from Homo sapiens)
Cryo-EM structure of human ATG9A in LMNG micelles
Wang Y, Dahmane S, Ti R, Mai X, Zhu L, Carlson LA, Stjepanovic G
Nat Struct Mol Biol (2025) 32 pp. 35-47 [ DOI: doi:10.1038/s41594-024-01376-6 Pubmed: 39174844 ]
- Atg9a trimer (283 kDa, Complex from Homo sapiens)
- Autophagy-related protein 9a (94 kDa, Protein from Homo sapiens)
Cryo-EM structure of human C-terminally bound ATG9A-ATG2A-WIPI4 complex
Wang Y, Dahmane S, Ti R, Mai X, Zhu L, Carlson LA, Stjepanovic G
Nat Struct Mol Biol (2025) 32 pp. 35-47 [ DOI: doi:10.1038/s41594-024-01376-6 Pubmed: 39174844 ]
- C-terminally bound atg9a-atg2a-wipi4 complex (536 kDa, Complex from Homo sapiens)
- Wd repeat domain phosphoinositide-interacting protein 4 (39 kDa, Protein from Homo sapiens)
- Autophagy-related protein 9a (94 kDa, Protein from Homo sapiens)
- Autophagy-related protein 2 homolog a (213 kDa, Protein from Homo sapiens)
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation
van Vliet AR, Chiduza GN, Maslen SL, Pye VE, Joshi D, De Tito S, Jefferies HBJ, Christodoulou E, Roustan C, Punch E, Hervas JH, O'Reilly N, Skehel JM, Cherepanov P, Tooze SA
Mol Cell (2022) 82 pp. 4324-4339.e8 [ DOI: doi:10.1016/j.molcel.2022.10.017 Pubmed: 36347259 ]
cryo-EM structure of human ATG9A in amphipols
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7jlo
Q-score: 0.536
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T
Nat Struct Mol Biol (2020) 27 pp. 1194-1201 [ DOI: doi:10.1038/s41594-020-00520-2 Pubmed: 33106659 ]
- Human atg9a in amphipols a8-35 (Cellular component from Homo sapiens)
- Autophagy-related protein 9a (66 kDa, Protein from Homo sapiens)
cryo-EM structure of human ATG9A in nanodiscs
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7jlp
Q-score: 0.552
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T
Nat Struct Mol Biol (2020) 27 pp. 1194-1201 [ DOI: doi:10.1038/s41594-020-00520-2 Pubmed: 33106659 ]
cryo-EM structure of human ATG9A in LMNG micelles
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7jlq
Q-score: 0.297
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T
Nat Struct Mol Biol (2020) 27 pp. 1194-1201 [ DOI: doi:10.1038/s41594-020-00520-2 Pubmed: 33106659 ]
- Human atg9a in lmng micelles (Cellular component from Homo sapiens)
- Autophagy-related protein 9a (66 kDa, Protein from Homo sapiens)
Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6wqz
Q-score: 0.5
Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gomez JD, Bonifacino JS, Jiang J, Banerjee A
Cell Rep (2020) 31 pp. 107837-107837 [ DOI: doi:10.1016/j.celrep.2020.107837 Pubmed: 32610138 ]
- Autophagy related 9a with lmng (Complex from Homo sapiens)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Autophagy-related protein 9a (81 kDa, Protein from Homo sapiens)
Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6wr4
Q-score: 0.526
Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gomez JD, Bonifacino JS, Jiang J, Banerjee A
Cell Rep (2020) 31 pp. 107837-107837 [ DOI: doi:10.1016/j.celrep.2020.107837 Pubmed: 32610138 ]
- Autophagy related 9a with lmng (Complex from Homo sapiens)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Autophagy-related protein 9a (94 kDa, Protein from Homo sapiens)