Cryo-EM structure of PGDM1400 Fab bound to HIV-1 BG505 DS-SOSIP.664 Env trimer
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 9d1w
Q-score: 0.483
Mason RD, Zhang B, Morano NC, Shen CH, McKee K, Heimann A, Du R, Nazzari AF, Hodges S, Kanai T, Lin BC, Louder MK, Doria-Rose NA, Zhou T, Shapiro L, Roederer M, Kwong PD, Gorman J
Cell Rep (2025) 44 pp. 115223-115223 [ DOI: doi:10.1016/j.celrep.2024.115223 Pubmed: 39826122 ]
- Pgdm1400 heavy chain (26 kDa, Protein from Homo sapiens)
- Pgdm1400 fab with hiv-1 bg505 ds-sosip.664 env trimer (Complex from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgdm1400 light chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of PGT145 R100aS Fab bound to HIV-1 BG505 DS-SOSIP.664 Env trimer
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 9d3d
Q-score: 0.474
Mason RD, Zhang B, Morano NC, Shen CH, McKee K, Heimann A, Du R, Nazzari AF, Hodges S, Kanai T, Lin BC, Louder MK, Doria-Rose NA, Zhou T, Shapiro L, Roederer M, Kwong PD, Gorman J
Cell Rep (2025) 44 pp. 115223-115223 [ DOI: doi:10.1016/j.celrep.2024.115223 Pubmed: 39826122 ]
- Bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt145 r100as fab with hiv-1 bg505 ds-sosip.664 env trimer (Complex from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgt145 light chain (23 kDa, Protein from Homo sapiens)
- Pgt145 r100as heavy chain (26 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8g4t
Q-score: 0.56
Wang S, Matassoli F, Zhang B, Liu T, Shen CH, Bylund T, Johnston T, Henry AR, Teng IT, Tripathi P, Becker JE, Changela A, Chaudhary R, Cheng C, Gaudinski M, Gorman J, Harris DR, Lee M, Morano NC, Novik L, O'Dell S, Olia AS, Parchment DK, Rawi R, Roberts-Torres J, Stephens T, Tsybovsky Y, Wang D, Van Wazer DJ, Zhou T, Doria-Rose NA, Koup RA, Shapiro L, Douek DC, McDermott AB, Kwong PD
Cell Rep (2023) 42 pp. 112755-112755 [ Pubmed: 37436899 DOI: doi:10.1016/j.celrep.2023.112755 ]
- Envelope glycoprotein bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Fab 2c09 heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein bg505 ds-sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Fab 2c09 light chain (23 kDa, Protein from Homo sapiens)
- Hiv envelope trimer in complex with three copies of antibody fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM Structure of PG9RSH DU011 Fab in complex with BG505 DS-SOSIP.664
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8fk5
Q-score: 0.456
Holt GT, Gorman J, Wang S, Lowegard AU, Zhang B, Liu T, Lin BC, Louder MK, Frenkel MS, McKee K, O'Dell S, Rawi R, Shen CH, Doria-Rose NA, Kwong PD, Donald BR
Cell Rep (2023) 42 pp. 112711-112711 [ Pubmed: 37436900 DOI: doi:10.1016/j.celrep.2023.112711 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Immunoglobulin lambda-1 light chain-like (22 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of pg9rsh du011 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Immunoblobulin g1 fab heavy chain variable region (fragment) (27 kDa, Protein from Homo sapiens)
Cryo-EM Structure of PG9RSH DU025 Fab in complex with BG505 DS-SOSIP.664
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8fl1
Q-score: 0.418
Holt GT, Gorman J, Wang S, Lowegard AU, Zhang B, Liu T, Lin BC, Louder MK, Frenkel MS, McKee K, O'Dell S, Rawi R, Shen CH, Doria-Rose NA, Kwong PD, Donald BR
Cell Rep (2023) 42 pp. 112711-112711 [ Pubmed: 37436900 DOI: doi:10.1016/j.celrep.2023.112711 ]
- Cryo-em structure of pg9rsh du025 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pg9 du025 light (22 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pg9 du025 heavy (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM Structure of PGT145 DU303 Fab in complex with BG505 DS-SOSIP.664
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8flw
Q-score: 0.432
Holt GT, Gorman J, Wang S, Lowegard AU, Zhang B, Liu T, Lin BC, Louder MK, Frenkel MS, McKee K, O'Dell S, Rawi R, Shen CH, Doria-Rose NA, Kwong PD, Donald BR
Cell Rep (2023) 42 pp. 112711-112711 [ Pubmed: 37436900 DOI: doi:10.1016/j.celrep.2023.112711 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of pgt145 du303 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Pgt145 du303 light (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt145 du303 heavy (27 kDa, Protein from Homo sapiens)