Cryo-EM structure of the human BRISC dimer complex bound to compound FX-171-C
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8pvy
Q-score: 0.332
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Datti A, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- Zinc ion (65 Da, Ligand)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
- N-[(1r,5s)-3-azabicyclo[3.1.0]hexan-6-yl]-1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]pyrazole-3-carboxamide (553 Da, Ligand)
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Brisc dimer in complex with inhibitor fx-171-c (654 kDa, Complex from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (35 kDa, Protein from Homo sapiens)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8py2
Q-score: 0.281
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Brisc dimer in complex with inhibitor jms-175-2 (654 kDa, Complex from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (36 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- 1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]-n-piperidin-4-yl-pyrazole-3-carboxamide (555 Da, Ligand)
Cryo-EM structure of the BRISC complex bound to SHMT2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6h3c
Q-score: 0.278
Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andres-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guerillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thoma NH
Mol Cell (2019) 75 pp. 483-497.e9 [ Pubmed: 31253574 DOI: doi:10.1016/j.molcel.2019.06.002 ]
- Brisc complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Shmt2 alpha (Complex from Homo sapiens)
- Brisc complex subunit abraxas 2 (49 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (45 kDa, Protein from Homo sapiens)
- Serine hydroxymethyltransferase, mitochondrial (56 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (38 kDa, Protein from Homo sapiens)
- Brisc complex bound to shmt2 alpha (438 kDa, Complex)
- Brisc and brca1-a complex member 1 (39 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the Human BRISC-SHMT2 complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6r8f
Q-score: 0.451
Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawlowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E
Nature (2019) 570 pp. 194-199 [ DOI: doi:10.1038/s41586-019-1232-1 Pubmed: 31142841 ]
- Brisc and brca1-a complex member 2,brcc45 (bre, brisc and brca1-a complex member 2) (22 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (36 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Serine hydroxymethyltransferase, mitochondrial (Complex from Homo sapiens)
- Merit40 (brisc and brca1-a complex member 1) (Complex from Homo sapiens)
- Brisc-shmt2 (388 MDa, Complex)
- Serine hydroxymethyltransferase, mitochondrial (56 kDa, Protein from Homo sapiens)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)