Gi bound mu-opioid receptor in complex with beta-endorphin
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8f7q
Q-score: 0.455
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Mu-type opioid receptor (45 kDa, Protein from Homo sapiens)
- Beta-endorphin (3 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Gi bound mu-opioid receptor in complex with endomorphin
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8f7r
Q-score: 0.395
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Mu-type opioid receptor (45 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Endomorphin (609 Da, Protein from Homo sapiens)
Gi bound delta-opioid receptor in complex with deltorphin
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8f7s
Q-score: 0.498
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Palmitic acid (256 Da, Ligand)
- Deltorphin (781 Da, Protein from Phyllomedusa)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Delta-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Gi bound kappa-opioid receptor in complex with dynorphin
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8f7w
Q-score: 0.456
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Dynorphin (983 Da, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Palmitic acid (256 Da, Ligand)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Gi bound nociceptin receptor in complex with nociceptin peptide
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8f7x
Q-score: 0.45
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nociceptin (1 kDa, Protein from Homo sapiens)
- Nociceptin receptor (40 kDa, Protein from Homo sapiens)