Structure of beta-arrestin1 in complex with C3aRpp
Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 8ja3
Q-score: 0.327
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
- Beta-arrestin-1 (40 kDa, Protein from Rattus norvegicus)
- Fab30 light chain (Complex from Mus musculus)
- C3a anaphylatoxin chemotactic receptor (1 kDa, Protein from Homo sapiens)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- Fab30 heavy chain (Complex from Mus musculus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin1 in complex with c3arpp (Complex)
- Beta-arrestin-1 (Complex from Rattus norvegicus)
- Phosphopeptide derived from the c-terminal tail of c3ar receptor (c3arpp) (Complex from Homo sapiens)
Structure of EP54-C3aR-Go complex
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8i95
Q-score: 0.561
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Structure of ep54-c3ar-go complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Ep54 ligand (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Ep54 ligand (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
Structure of Apo-C3aR-Go complex (Glacios)
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8i97
Q-score: 0.5
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Structure of apo-c3ar-go complex (glacios) (Complex)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
Structure of EP54-C3aR-Gq complex
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8i9a
Q-score: 0.431
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Structure of ep54-c3ar-gq complex (Complex)
- Guanine nucleotide-binding protein g(q) subunit alpha (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Ep54 ligand (Complex from Homo sapiens)
- Ep54 ligand (1 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
Structure of C3a-C3aR-Go complex (Composite map)
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8i9l
Q-score: 0.468
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- C3a ligand (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- Structure of c3a-c3ar-go complex (Complex)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
Structure of Apo-C3aR-Go complex (Titan)
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8i9s
Q-score: 0.458
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Structure of apo-c3ar-go complex (titan) (Complex)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
Structure of EP141-C3aR-Go complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j6d
Q-score: 0.461
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Structure of ep141-c3ar-go complex (Complex from Homo sapiens)
- Ep141 peptide agonist (1 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8ia8
Q-score: 0.571
To Be Published
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C3ar-gi (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Ala-ser-lys-leu-gly-leu-ala-arg (1 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Vicugna pacos)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- C3ar-gi-scfv16-e7 complex (150 kDa, Complex)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- C3a-analog peptide e7 (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hk2
Q-score: 0.48
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Palmitic acid (256 Da, Ligand)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C3ar-gi-c3a protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hk3
Q-score: 0.438
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- C3ar-gi-apo protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)