Structure of EP54-C3aR-Go complex
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8i95
Q-score: 0.561
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Ep54 ligand (1 kDa, Protein from Homo sapiens)
- Structure of ep54-c3ar-go complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Ep54 ligand (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8ia8
Q-score: 0.571
To Be Published
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Vicugna pacos)
- C3ar-gi-scfv16-e7 complex (150 kDa, Complex)
- C3a-analog peptide e7 (Complex from Homo sapiens)
- Ala-ser-lys-leu-gly-leu-ala-arg (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- C3ar-gi (Complex from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hk2
Q-score: 0.48
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ DOI: doi:10.1038/s41589-023-01339-w Pubmed: 37169960 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- C3ar-gi-c3a protein complex (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)