Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8b0g
Q-score: 0.399
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ DOI: doi:10.1038/s41467-023-36441-z Pubmed: 36797260 ]
- Complement component c8 beta chain (67 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (9 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (22 kDa, Protein from Homo sapiens)
- Complement component c6 (104 kDa, Protein from Homo sapiens)
- 2c9, cd59 inhibited mac complex (Complex from Homo sapiens)
- Complement component c7 (93 kDa, Protein from Homo sapiens)
- Complement c5 (188 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (65 kDa, Protein from Homo sapiens)
- Complement component c9 (63 kDa, Protein from Homo sapiens)
2C9, C5b9-CD59 cryoEM structure
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8b0h
Q-score: 0.405
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ DOI: doi:10.1038/s41467-023-36441-z Pubmed: 36797260 ]
- Complement component c8 beta chain (67 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (22 kDa, Protein from Homo sapiens)
- Complement component c6 (104 kDa, Protein from Homo sapiens)
- 2c9, cd59 inhibited mac complex (Complex)
- Complement component c7 (93 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (14 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (65 kDa, Protein from Homo sapiens)
- Complement c5 (188 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (Complex from Homo sapiens)
- Complement component c9 (63 kDa, Protein from Homo sapiens)
- Complement components c5, c6, c7, c8 and c9 (Complex from Homo sapiens)
2C9, C5b9-CD59 cryoEM structure; focus refinement map
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ DOI: doi:10.1038/s41467-023-36441-z Pubmed: 36797260 ]
3C9, C5b9-CD59 cryoEM structure; focus refinement map
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ DOI: doi:10.1038/s41467-023-36441-z Pubmed: 36797260 ]
cryoEM reconstruction of the terminal C9s and chaperone in 3C9-sMAC
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- 3c9-smac (Complex from Homo sapiens)
cryoEM reconstruction of the terminal C9s in 2C9-sMAC
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- 2c9-smac (Complex from Homo sapiens)
cryoEM reconstruction of C5b and C7 C-ter in 2C9-sMAC
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- 2c9-smac (Complex from Homo sapiens)
cryoEM reconstruction of 1C9-sMAC
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- 1c9-smac (1 MDa, Complex from Homo sapiens)
- Complement protein c7 (Protein from Homo sapiens)
- Complement protein c8 beta (Protein from Homo sapiens)
- Complement protein c8 gamma (Protein from Homo sapiens)
- Complement protein c8 alpha (Protein from Homo sapiens)
- Complement protein c9 (Protein from Homo sapiens)
- Complement protein c5b (Protein from Homo sapiens)
- Complement protein c6 (Protein from Homo sapiens)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7nyc
Q-score: 0.226
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- 3c9-smac (1 MDa, Complex from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Complement c5 (186 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Alpha-l-fucopyranose (164 Da, Ligand)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7nyd
Q-score: 0.335
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Complement c5 (186 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Alpha-l-fucopyranose (164 Da, Ligand)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- 2c9-smac (1 MDa, Complex from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)