OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h03
Q-score: 0.156
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Closed conformation of the Membrane Attack Complex
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h04
Q-score: 0.179
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Asymmetric region of the Membrane Attack Complex in the closed conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Consensus map of the Membrane Attack Complex
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Asymmetric region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Hinge region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
C9 oligomer region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- Membrane attack complex (690 kDa, Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
Electron cryo-microscopy of an immune pore
Serna M, Giles JL, Morgan BP, Bubeck D
Nat Commun (2016) 7 pp. 10587-10587 [ Pubmed: 26841837 DOI: doi:10.1038/ncomms10587 ]
- Membrane attack complex (1 MDa, Sample)
- C7 (110 kDa, Protein from Homo sapiens)
- C8 gamma (152 kDa, Protein from Homo sapiens)
- C6 (120 kDa, Protein from Homo sapiens)
- C8 alpha (152 kDa, Protein from Homo sapiens)
- C8 beta (152 kDa, Protein from Homo sapiens)
- C5 (190 kDa, Protein from Homo sapiens)
- C9 (69 kDa, Protein from Homo sapiens)
Electron cryo-microscopy of an immune pore
Serna M, Giles JL, Morgan BP, Bubeck D
Nat Commun (2016) 7 pp. 10587-10587 [ Pubmed: 26841837 DOI: doi:10.1038/ncomms10587 ]
- Membrane attack complex (1 MDa, Sample)
- C7 (110 kDa, Protein from Homo sapiens)
- C8 gamma (152 kDa, Protein from Homo sapiens)
- C6 (120 kDa, Protein from Homo sapiens)
- C8 alpha (152 kDa, Protein from Homo sapiens)
- C8 beta (152 kDa, Protein from Homo sapiens)
- C5 (190 kDa, Protein from Homo sapiens)
- C9 (69 kDa, Protein from Homo sapiens)
Structure of complement component complex, sC5b9.
Hadders MA, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan BP, Pangburn MK, Llorca O, Lea SM, Gros P
Cell Rep (2012) 1 pp. 200-207 [ Pubmed: 22832194 DOI: doi:10.1016/j.celrep.2012.02.003 ]
- Clusterin (Protein from Homo sapiens)
- C9 (Protein from Homo sapiens)
- Vibronectin (Protein from Homo sapiens)
- C5b (Protein from Homo sapiens)
- C8 (Protein from Homo sapiens)
- C6 (Protein from Homo sapiens)
- C7 (Protein from Homo sapiens)
- Sc5b9 (Sample)