Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8b0g
Q-score: 0.399
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ DOI: doi:10.1038/s41467-023-36441-z Pubmed: 36797260 ]
- Complement component c8 beta chain (67 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (9 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (22 kDa, Protein from Homo sapiens)
- Complement component c6 (104 kDa, Protein from Homo sapiens)
- 2c9, cd59 inhibited mac complex (Complex from Homo sapiens)
- Complement component c7 (93 kDa, Protein from Homo sapiens)
- Complement c5 (188 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (65 kDa, Protein from Homo sapiens)
- Complement component c9 (63 kDa, Protein from Homo sapiens)
2C9, C5b9-CD59 cryoEM structure
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8b0h
Q-score: 0.405
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ DOI: doi:10.1038/s41467-023-36441-z Pubmed: 36797260 ]
- Complement component c8 beta chain (67 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (22 kDa, Protein from Homo sapiens)
- Complement component c6 (104 kDa, Protein from Homo sapiens)
- 2c9, cd59 inhibited mac complex (Complex)
- Complement component c7 (93 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (14 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (65 kDa, Protein from Homo sapiens)
- Complement c5 (188 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (Complex from Homo sapiens)
- Complement component c9 (63 kDa, Protein from Homo sapiens)
- Complement components c5, c6, c7, c8 and c9 (Complex from Homo sapiens)
Cryo-EM structure of Brr2 in complex with Jab1/MPN and C9ORF78
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 7os2
Q-score: 0.543
Bergfort A, Hilal T, Kuropka B, Ilik IA, Weber G, Aktas T, Freund C, Wahl MC
Nucleic Acids Res (2022) 50 pp. 2938-2958 [ DOI: doi:10.1093/nar/gkac087 Pubmed: 35188580 ]
- Pre-mrna-processing-splicing factor 8 (prp8) jab1/mpn domain (Complex from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (brr2) (Complex from Homo sapiens)
- Telomere length and silencing protein 1 homolog (c9orf78) (Complex from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (198 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (31 kDa, Protein from Homo sapiens)
- Trimeric complex of brr2, the jab1/mpn domain of prp8 and a n-terminal fragment of c9orf78 (Complex from Homo sapiens)
- Telomere length and silencing protein 1 homolog (34 kDa, Protein from Homo sapiens)
cryoEM reconstruction of 1C9-sMAC
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- 1c9-smac (1 MDa, Complex from Homo sapiens)
- Complement protein c7 (Protein from Homo sapiens)
- Complement protein c8 beta (Protein from Homo sapiens)
- Complement protein c8 gamma (Protein from Homo sapiens)
- Complement protein c8 alpha (Protein from Homo sapiens)
- Complement protein c9 (Protein from Homo sapiens)
- Complement protein c5b (Protein from Homo sapiens)
- Complement protein c6 (Protein from Homo sapiens)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7nyc
Q-score: 0.226
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- 3c9-smac (1 MDa, Complex from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Complement c5 (186 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Alpha-l-fucopyranose (164 Da, Ligand)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7nyd
Q-score: 0.335
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ DOI: doi:10.1038/s41467-021-26366-w Pubmed: 34667172 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Complement c5 (186 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Alpha-l-fucopyranose (164 Da, Ligand)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- 2c9-smac (1 MDa, Complex from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike (2P) in complex with C12C9 Fab (RBD local reconstruction)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7n62
Q-score: 0.428
Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR
bioRxiv (2021) [ Pubmed: 33758863 DOI: doi:10.1101/2021.03.10.434840 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with 12-c9 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- C12c9 fab heavy chain (24 kDa, Protein from Homo sapiens)
- C12c9 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SMCR8-C9orf72-WDR41 complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6v4u
Q-score: 0.296
Su MY, Fromm SA, Zoncu R, Hurley JH
Nature (2020) 585 pp. 251-255 [ DOI: doi:10.1038/s41586-020-2633-x Pubmed: 32848248 ]
- Guanine nucleotide exchange protein smcr8 (105 kDa, Protein from Homo sapiens)
- Complex of smcr8-c9orf72-wdr41 (120 kDa, Complex from Homo sapiens)
- Wd repeat-containing protein 41 (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide exchange c9orf72 (54 kDa, Protein from Homo sapiens)
cryo-EM structure of C9ORF72-SMCR8-WDR41
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6lt0
Q-score: 0.26
Tang D, Sheng J, Xu L, Zhan X, Liu J, Jiang H, Shu X, Liu X, Zhang T, Jiang L, Zhou C, Li W, Cheng W, Li Z, Wang K, Lu K, Yan C, Qi S
PNAS (2020) 117 pp. 9876-9883 [ Pubmed: 32303654 DOI: doi:10.1073/pnas.2002110117 ]
- Guanine nucleotide exchange protein smcr8 (105 kDa, Protein from Homo sapiens)
- Dimer of c9-orf72-smcr8-wdr41 (400 kDa, Complex from Homo sapiens)
- Wd repeat-containing protein 41 (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide exchange c9orf72 (54 kDa, Protein from Homo sapiens)
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h03
Q-score: 0.156
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)