the Planar Cell Polarity Core Protein Vangl1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8zxd
Q-score: 0.442
To Be Published
- Vang-like protein 1 (Complex from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Vang-like protein 1 (60 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4,200 mM KCl
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1j
Q-score: 0.489
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ DOI: doi:10.1073/pnas.2320345121 Pubmed: 38630723 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 5 mM KCl and 135 mM NaCl
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8k1q
Q-score: 0.41
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ DOI: doi:10.1073/pnas.2320345121 Pubmed: 38630723 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8k1v
Q-score: 0.422
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ DOI: doi:10.1073/pnas.2320345121 Pubmed: 38630723 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8k1z
Q-score: 0.42
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ DOI: doi:10.1073/pnas.2320345121 Pubmed: 38630723 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human neuronal gap junction channel connexin 36
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8iyg
Q-score: 0.422
Arch.Biochem.Biophys. (2024) 754 pp. 109959-109959 [ Pubmed: 38490311 DOI: doi:10.1016/j.abb.2024.109959 ]
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Human neuronal gap junction channel connexin 36 (Complex from Homo sapiens)
- Gap junction delta-2 protein (36 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of an orphan GPCR-Gi protein signaling complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g05
Q-score: 0.524
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C
Nat Commun (2023) 14 pp. 5706-5706 [ Pubmed: 37709767 DOI: doi:10.1038/s41467-023-41201-0 ]
- 6-(octylamino)pyrimidine-2,4(3h,5h)-dione (239 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (48 kDa, Protein from Homo sapiens)
- 6oau_gpr84_dngi_scfv16 (Complex from Spodoptera frugiperda)
Cryo-EM structure of CMKLR1 signaling complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8sg1
Q-score: 0.546
Zhang X, Weiss T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M, Bahar I, Beck-Sickinger AG, Zhang C
PLoS Biol (2023) 21 pp. e3002188-e3002188 [ DOI: doi:10.1371/journal.pbio.3002188 Pubmed: 38055679 ]
- Chemerin9-cmklr1-gi complex (Complex from Spodoptera frugiperda)
- Chemerin-like receptor 1 (33 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemerin 9 (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8kh5
Q-score: 0.514
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ Pubmed: 37737235 DOI: doi:10.1038/s41467-023-41654-3 ]
- Probable g-protein coupled receptor 174 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr174 and mini-gs complex with nb35 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- O-{hydroxy[((2r)-2-hydroxy-3-{[(1s)-1-hydroxypentadecyl]oxy}propyl)oxy]phosphoryl}-l-serine (485 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Gs complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Gpr174 (Complex from Homo sapiens)
- Nb35 (Complex from Lama glama)
Cryo-EM structure of the GPR161-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8kh4
Q-score: 0.48
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ Pubmed: 37737235 DOI: doi:10.1038/s41467-023-41654-3 ]
- Cryo-em structure of the gpr161 and mini-gs complex with nb35 (Complex from Homo sapiens)
- G-protein coupled receptor 161 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(olf) subunit alpha,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)