Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4,200 mM KCl
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1j
Q-score: 0.489
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 5 mM KCl and 135 mM NaCl
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8k1q
Q-score: 0.41
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8k1v
Q-score: 0.422
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8k1z
Q-score: 0.42
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ DOI: doi:10.1073/pnas.2320345121 Pubmed: 38630723 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human neuronal gap junction channel connexin 36
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8iyg
Q-score: 0.422
Arch.Biochem.Biophys. (2024) 754 pp. 109959-109959 [ DOI: doi:10.1016/j.abb.2024.109959 Pubmed: 38490311 ]
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Gap junction delta-2 protein (36 kDa, Protein from Homo sapiens)
- Human neuronal gap junction channel connexin 36 (Complex from Homo sapiens)
Cryo-EM structure of an orphan GPCR-Gi protein signaling complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g05
Q-score: 0.524
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C
Nat Commun (2023) 14 pp. 5706-5706 [ DOI: doi:10.1038/s41467-023-41201-0 Pubmed: 37709767 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 6oau_gpr84_dngi_scfv16 (Complex from Spodoptera frugiperda)
- G-protein coupled receptor 84 (48 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 6-(octylamino)pyrimidine-2,4(3h,5h)-dione (239 Da, Ligand)
Cryo-EM structure of CMKLR1 signaling complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8sg1
Q-score: 0.546
Zhang X, Weiss T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M, Bahar I, Beck-Sickinger AG, Zhang C
PLoS Biol (2023) 21 pp. e3002188-e3002188 [ DOI: doi:10.1371/journal.pbio.3002188 Pubmed: 38055679 ]
- Palmitic acid (256 Da, Ligand)
- Chemerin-like receptor 1 (33 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemerin 9 (1 kDa, Protein from Homo sapiens)
- Chemerin9-cmklr1-gi complex (Complex from Spodoptera frugiperda)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (36 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8kh5
Q-score: 0.514
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ Pubmed: 37737235 DOI: doi:10.1038/s41467-023-41654-3 ]
- O-{hydroxy[((2r)-2-hydroxy-3-{[(1s)-1-hydroxypentadecyl]oxy}propyl)oxy]phosphoryl}-l-serine (485 Da, Ligand)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gpr174 (Complex from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr174 and mini-gs complex with nb35 (Complex)
- Probable g-protein coupled receptor 174 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GPR161-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8kh4
Q-score: 0.48
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ Pubmed: 37737235 DOI: doi:10.1038/s41467-023-41654-3 ]
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(olf) subunit alpha,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 161 (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr161 and mini-gs complex with nb35 (Complex from Homo sapiens)
Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7y27
Q-score: 0.464
Nat Chem Biol (2023) 19 pp. 133-140 [ DOI: doi:10.1038/s41589-022-01130-3 Pubmed: 36138141 ]
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Single fab chain (svfv16) (27 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- G(q) subunit alpha, sstr2, svfv16 (Complex)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Sst-14 (Complex)
- Complex of sstr2-minigq-scfv16 bound with sst-14 (Complex from Homo sapiens)