the Planar Cell Polarity Core Protein Vangl1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8zxd
Q-score: 0.442
To Be Published
- Vang-like protein 1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Vang-like protein 1 (60 kDa, Protein from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4,200 mM KCl
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1j
Q-score: 0.489
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 5 mM KCl and 135 mM NaCl
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8k1q
Q-score: 0.41
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8k1v
Q-score: 0.422
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8k1z
Q-score: 0.42
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Human neuronal gap junction channel connexin 36
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8iyg
Q-score: 0.422
Arch.Biochem.Biophys. (2024) 754 pp. 109959-109959 [ Pubmed: 38490311 DOI: doi:10.1016/j.abb.2024.109959 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Gap junction delta-2 protein (36 kDa, Protein from Homo sapiens)
- Human neuronal gap junction channel connexin 36 (Complex from Homo sapiens)
Cryo-EM structure of an orphan GPCR-Gi protein signaling complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g05
Q-score: 0.524
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C
Nat Commun (2023) 14 pp. 5706-5706 [ Pubmed: 37709767 DOI: doi:10.1038/s41467-023-41201-0 ]
- 6-(octylamino)pyrimidine-2,4(3h,5h)-dione (239 Da, Ligand)
- G-protein coupled receptor 84 (48 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 6oau_gpr84_dngi_scfv16 (Complex from Spodoptera frugiperda)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of CMKLR1 signaling complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8sg1
Q-score: 0.546
Zhang X, Weiss T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M, Bahar I, Beck-Sickinger AG, Zhang C
PLoS Biol (2023) 21 pp. e3002188-e3002188 [ DOI: doi:10.1371/journal.pbio.3002188 Pubmed: 38055679 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemerin-like receptor 1 (33 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Chemerin9-cmklr1-gi complex (Complex from Spodoptera frugiperda)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (36 kDa, Protein from Homo sapiens)
- Chemerin 9 (1 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8kh5
Q-score: 0.514
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ DOI: doi:10.1038/s41467-023-41654-3 Pubmed: 37737235 ]
- Gpr174 (Complex from Homo sapiens)
- Probable g-protein coupled receptor 174 (39 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- O-{hydroxy[((2r)-2-hydroxy-3-{[(1s)-1-hydroxypentadecyl]oxy}propyl)oxy]phosphoryl}-l-serine (485 Da, Ligand)
- Gs complex (Complex from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Cryo-em structure of the gpr174 and mini-gs complex with nb35 (Complex)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of the GPR161-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8kh4
Q-score: 0.48
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ DOI: doi:10.1038/s41467-023-41654-3 Pubmed: 37737235 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 161 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(olf) subunit alpha,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr161 and mini-gs complex with nb35 (Complex from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)