Dopamine Receptor D1R-Gs-Rotigotine complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8irr
Q-score: 0.513
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Nanoboy 35 (14 kDa, Protein from Lama glama)
- Rotigotine (315 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Dopamine receptor d1r-gs-rotigotine complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Dopamine Receptor D4R-Gi-Rotigotine complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8iru
Q-score: 0.485
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Dopamine receptor d4r-gi-rotigotine complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- D(4) dopamine receptor (83 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Rotigotine (315 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
Dopamine Receptor D5R-Gs-Rotigotine complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8irv
Q-score: 0.517
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Dopamine receptor d5r-gs-rotigotine complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Rotigotine (315 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,d(1b) dopamine receptor (68 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hk2
Q-score: 0.48
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ DOI: doi:10.1038/s41589-023-01339-w Pubmed: 37169960 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- C3ar-gi-c3a protein complex (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Fentanyl-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ef5
Q-score: 0.39
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- N-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (336 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Morphine-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ef6
Q-score: 0.471
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (7r,7as,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1h-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol (285 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
SR17018-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8efl
Q-score: 0.463
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2h-benzimidazol-2-one (410 Da, Ligand)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
PZM21-bound mu-opioid receptor-Gi complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8efo
Q-score: 0.472
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- N-[(2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-n'-[(2s)-1-(thiophen-3-yl)propan-2-yl]urea (361 Da, Ligand)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
ghrelin-bound ghrelin receptor in complex with Gq
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f9y
Q-score: 0.469
Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y
Nat Commun (2021) 12 pp. 5064-5064 [ DOI: doi:10.1038/s41467-021-25364-2 Pubmed: 34417468 ]
- Octanoic acid (caprylic acid) (144 Da, Ligand)
- Soluble cytochrome b562 (74 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ghrelin-bound ghrelin receptor in complex with gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Engineered g-alpha-q subunit (41 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Ghrelin-28 (3 kDa, Protein from Homo sapiens)