Structure of TRPC3 at 2.7 angstrom in high calcium state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7dxb
Q-score: 0.56
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of TRPC3 at 3.06 angstrom in low calcium state
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 7dxc
Q-score: 0.454
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
Structure of TRPC3 gain of function mutation R803C at 3.2 angstrom in 1340nM free calcium state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7dxe
Q-score: 0.51
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dxf
Q-score: 0.515
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 6 (106 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human transient receptor potential channel 6 tetramer (Complex from Homo sapiens)
- [2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-[(3r,5s)-3,5-dimethylpiperidin-1-yl]methanone (359 Da, Ligand)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of SAR7334-bound TRPC6 at 2.9 angstrom
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dxg
Q-score: 0.551
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 6 (106 kDa, Protein from Homo sapiens)
- 4-[[(1r,2r)-2-[(3r)-3-azanylpiperidin-1-yl]-2,3-dihydro-1h-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile (367 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human transient receptor potential channel 6 tetramer (Complex from Homo sapiens)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of TRPC3 at 3.9 angstrom in 1340 nM free calcium state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7dxd
Q-score: 0.383
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
Structure of human TRPC5 in complex with clemizole
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7d4p
Q-score: 0.563
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole (325 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Structure of human TRPC5 in complex with HC-070
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7d4q
Q-score: 0.581
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione (475 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Human TRPC5 apo state structure at 3 angstrom
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7e4t
Q-score: 0.518
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Structure of mammalian NALCN-FAM155A complex at 2.65 angstrom
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 7cu3
Q-score: 0.618
Nat Commun (2020) 11 pp. 6199-6199 [ DOI: doi:10.1038/s41467-020-20002-9 Pubmed: 33273469 ]
- Nalcn-fam155a complex (Complex from Homo sapiens)
- Transmembrane protein fam155a (52 kDa, Protein from Mus musculus)
- Sodium leak channel non-selective protein (200 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)