Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8y69
Q-score: 0.391
To Be Published
- E3 ubiquitin-protein ligase znrf3 (20 kDa, Protein from Homo sapiens)
- The di-heterotrimer complex of lgr4-rspo2-znrf3(delete ring domain) (Complex from Homo sapiens)
- Leucine-rich repeat-containing g-protein coupled receptor 4 (87 kDa, Protein from Homo sapiens)
- Mb52 (59 kDa, Protein from Camelus bactrianus)
- R-spondin-2 (11 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of the apo hTAAR1-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8zsj
Q-score: 0.542
Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F
Cell Rep (2024) 43 pp. 114505-114505 [ DOI: doi:10.1016/j.celrep.2024.114505 Pubmed: 39002128 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- The apo htaar1-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (56 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9asb
Q-score: 0.524
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ DOI: doi:10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (19r,22s,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9z)-octadec-9-enoate (749 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Chimeric mini guanine nucleotide-binding protein g(i)(s)(q) subunit alpha (28 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human casr in complex with chimeric gq (minigisq) protein (276 kDa, Complex from Homo sapiens)
- Chimeric mini guanine nucleotide-binding protein g(i)(s)(q) subunit alpha (7 kDa, Protein from Homo sapiens)
- Cyclomethyltryptophan (216 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9avg
Q-score: 0.509
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ DOI: doi:10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Human casr in complex with chimeric gs (minigis) protein (276 kDa, Complex from Homo sapiens)
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Chimeric mini guanine nucleotide-binding protein g(i)(s) subunit alpha (28 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (19r,22s,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9z)-octadec-9-enoate (749 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclomethyltryptophan (216 Da, Ligand)
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9avl
Q-score: 0.532
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ DOI: doi:10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (19r,22s,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9z)-octadec-9-enoate (749 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human casr in complex with gi3 protein (288 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-2 (38 kDa, Protein from Homo sapiens)
- Cyclomethyltryptophan (216 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9axf
Q-score: 0.56
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ DOI: doi:10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Nanobody nb-35 (17 kDa, Protein from Lama glama)
- Calcium ion (40 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,adenylate cyclase-stimulating g alpha protein (28 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human casr in complex with chimeric gq (minigisq) protein (319 kDa, Complex from Homo sapiens)
- Extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Cyclomethyltryptophan (216 Da, Ligand)
- Single-chain antibody fragment scfv16 (31 kDa, Protein from Mus musculus)
Pendrin in complex with chloride
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8sgw
Q-score: 0.556
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ DOI: doi:10.1038/s41467-023-44612-1 Pubmed: 38184688 ]
- Chloride ion (35 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Pendrin (86 kDa, Protein from Sus scrofa)
Pendrin in complex with iodide
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sh3
Q-score: 0.544
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ DOI: doi:10.1038/s41467-023-44612-1 Pubmed: 38184688 ]
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Iodide ion (126 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
Pendrin in complex with Niflumic acid
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8shc
Q-score: 0.536
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ DOI: doi:10.1038/s41467-023-44612-1 Pubmed: 38184688 ]
- Chloride ion (35 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid (282 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
Pendrin in complex with bicarbonate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8sie
Q-score: 0.574
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ DOI: doi:10.1038/s41467-023-44612-1 Pubmed: 38184688 ]
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Bicarbonate ion (61 Da, Ligand)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Pendrin (86 kDa, Protein from Sus scrofa)