Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8y69
Q-score: 0.391
To Be Published
- Leucine-rich repeat-containing g-protein coupled receptor 4 (87 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase znrf3 (20 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Mb52 (59 kDa, Protein from Camelus bactrianus)
- The di-heterotrimer complex of lgr4-rspo2-znrf3(delete ring domain) (Complex from Homo sapiens)
- R-spondin-2 (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of the apo hTAAR1-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8zsj
Q-score: 0.542
Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F
Cell Rep (2024) 43 pp. 114505-114505 [ Pubmed: 39002128 DOI: doi:10.1016/j.celrep.2024.114505 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (56 kDa, Protein from Homo sapiens)
- The apo htaar1-gs complex (Complex from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9asb
Q-score: 0.524
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]
- Cyclomethyltryptophan (216 Da, Ligand)
- (19r,22s,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9z)-octadec-9-enoate (749 Da, Ligand)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Human casr in complex with chimeric gq (minigisq) protein (276 kDa, Complex from Homo sapiens)
- Chimeric mini guanine nucleotide-binding protein g(i)(s)(q) subunit alpha (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Chimeric mini guanine nucleotide-binding protein g(i)(s)(q) subunit alpha (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9avg
Q-score: 0.509
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]
- Cyclomethyltryptophan (216 Da, Ligand)
- Chimeric mini guanine nucleotide-binding protein g(i)(s) subunit alpha (28 kDa, Protein from Homo sapiens)
- (19r,22s,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9z)-octadec-9-enoate (749 Da, Ligand)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Human casr in complex with chimeric gs (minigis) protein (276 kDa, Complex from Homo sapiens)
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9avl
Q-score: 0.532
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]
- Cyclomethyltryptophan (216 Da, Ligand)
- (19r,22s,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9z)-octadec-9-enoate (749 Da, Ligand)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-2 (38 kDa, Protein from Homo sapiens)
- Human casr in complex with gi3 protein (288 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9axf
Q-score: 0.56
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]
- Cyclomethyltryptophan (216 Da, Ligand)
- Extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Single-chain antibody fragment scfv16 (31 kDa, Protein from Mus musculus)
- Nanobody nb-35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,adenylate cyclase-stimulating g alpha protein (28 kDa, Protein from Homo sapiens)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Human casr in complex with chimeric gq (minigisq) protein (319 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
Pendrin in complex with chloride
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8sgw
Q-score: 0.556
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
Pendrin in complex with iodide
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sh3
Q-score: 0.544
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Iodide ion (126 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
Pendrin in complex with Niflumic acid
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8shc
Q-score: 0.536
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Pendrin (86 kDa, Protein from Sus scrofa)
- 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid (282 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
Pendrin in complex with bicarbonate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8sie
Q-score: 0.574
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Bicarbonate ion (61 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)